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Quantitative Characterization of Gait Patterns in Individuals with Spinocerebellar Ataxia 38
Spinocerebellar ataxia 38 (SCA 38) is a rare autosomal neurological disease whose clinical features include, among others, severe gait disturbances that have not yet been fully characterized. In this study, we employed a computerized 3D gait analysis to obtain spatio-temporal parameters of gait and...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10376738/ https://www.ncbi.nlm.nih.gov/pubmed/37508815 http://dx.doi.org/10.3390/bioengineering10070788 |
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author | Pau, Massimiliano Porta, Micaela Pau, Chiara Tacconi, Paolo Sanna, Angela |
author_facet | Pau, Massimiliano Porta, Micaela Pau, Chiara Tacconi, Paolo Sanna, Angela |
author_sort | Pau, Massimiliano |
collection | PubMed |
description | Spinocerebellar ataxia 38 (SCA 38) is a rare autosomal neurological disease whose clinical features include, among others, severe gait disturbances that have not yet been fully characterized. In this study, we employed a computerized 3D gait analysis to obtain spatio-temporal parameters of gait and the kinematics in the sagittal plane in the hip, knee, and ankle joints of seven individuals with SCA 38, which were then compared with those of twenty unaffected individuals matched for age, sex, and anthropometric features. The results show that, in comparison with unaffected individuals, those with SCA 38 are characterized by a significantly reduced speed, stride length, and duration of the swing phase, as well as an increased step width and stance and double support phase durations. The point-by-point comparison of the angular trends at the hip, knee, and ankle joints revealed significant alterations during most part of the stance phase for hip joint and at pre-swing/swing phases for knee and ankle joints. For these latter joints, a significantly reduced dynamic range of motion was also found. Such findings provide some new insights into hip and knee kinematics for this specific form of ataxia and may be useful for monitoring the disease’s progression and designing specific, tailored rehabilitative interventions. |
format | Online Article Text |
id | pubmed-10376738 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-103767382023-07-29 Quantitative Characterization of Gait Patterns in Individuals with Spinocerebellar Ataxia 38 Pau, Massimiliano Porta, Micaela Pau, Chiara Tacconi, Paolo Sanna, Angela Bioengineering (Basel) Article Spinocerebellar ataxia 38 (SCA 38) is a rare autosomal neurological disease whose clinical features include, among others, severe gait disturbances that have not yet been fully characterized. In this study, we employed a computerized 3D gait analysis to obtain spatio-temporal parameters of gait and the kinematics in the sagittal plane in the hip, knee, and ankle joints of seven individuals with SCA 38, which were then compared with those of twenty unaffected individuals matched for age, sex, and anthropometric features. The results show that, in comparison with unaffected individuals, those with SCA 38 are characterized by a significantly reduced speed, stride length, and duration of the swing phase, as well as an increased step width and stance and double support phase durations. The point-by-point comparison of the angular trends at the hip, knee, and ankle joints revealed significant alterations during most part of the stance phase for hip joint and at pre-swing/swing phases for knee and ankle joints. For these latter joints, a significantly reduced dynamic range of motion was also found. Such findings provide some new insights into hip and knee kinematics for this specific form of ataxia and may be useful for monitoring the disease’s progression and designing specific, tailored rehabilitative interventions. MDPI 2023-07-01 /pmc/articles/PMC10376738/ /pubmed/37508815 http://dx.doi.org/10.3390/bioengineering10070788 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Pau, Massimiliano Porta, Micaela Pau, Chiara Tacconi, Paolo Sanna, Angela Quantitative Characterization of Gait Patterns in Individuals with Spinocerebellar Ataxia 38 |
title | Quantitative Characterization of Gait Patterns in Individuals with Spinocerebellar Ataxia 38 |
title_full | Quantitative Characterization of Gait Patterns in Individuals with Spinocerebellar Ataxia 38 |
title_fullStr | Quantitative Characterization of Gait Patterns in Individuals with Spinocerebellar Ataxia 38 |
title_full_unstemmed | Quantitative Characterization of Gait Patterns in Individuals with Spinocerebellar Ataxia 38 |
title_short | Quantitative Characterization of Gait Patterns in Individuals with Spinocerebellar Ataxia 38 |
title_sort | quantitative characterization of gait patterns in individuals with spinocerebellar ataxia 38 |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10376738/ https://www.ncbi.nlm.nih.gov/pubmed/37508815 http://dx.doi.org/10.3390/bioengineering10070788 |
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