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“Could Patient Age and Gender, along with Mass Size, Be Predictive Factors for Benign Kidney Tumors?”: A Retrospective Analysis of 307 Consecutive Single Renal Masses Treated with Partial or Radical Nephrectomy

Due to the increased use of common and non-invasive abdominal imaging techniques over the last few decades, the diagnosis of about 60% of renal tumors is incidental. Contrast-enhancing renal nodules on computed tomography are diagnosed as malignant tumors, which are often removed surgically without...

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Autores principales: Baio, Raffaele, Molisso, Giovanni, Caruana, Christian, Di Mauro, Umberto, Intilla, Olivier, Pane, Umberto, D’Angelo, Costantino, Campitelli, Antonio, Pentimalli, Francesca, Sanseverino, Roberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10376757/
https://www.ncbi.nlm.nih.gov/pubmed/37508821
http://dx.doi.org/10.3390/bioengineering10070794
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author Baio, Raffaele
Molisso, Giovanni
Caruana, Christian
Di Mauro, Umberto
Intilla, Olivier
Pane, Umberto
D’Angelo, Costantino
Campitelli, Antonio
Pentimalli, Francesca
Sanseverino, Roberto
author_facet Baio, Raffaele
Molisso, Giovanni
Caruana, Christian
Di Mauro, Umberto
Intilla, Olivier
Pane, Umberto
D’Angelo, Costantino
Campitelli, Antonio
Pentimalli, Francesca
Sanseverino, Roberto
author_sort Baio, Raffaele
collection PubMed
description Due to the increased use of common and non-invasive abdominal imaging techniques over the last few decades, the diagnosis of about 60% of renal tumors is incidental. Contrast-enhancing renal nodules on computed tomography are diagnosed as malignant tumors, which are often removed surgically without first performing a biopsy. Most kidney nodules are renal cell carcinoma (RCC) after surgical treatment, but a non-negligible rate of these nodules may be benign on final pathology; as a result, patients undergo unnecessary surgery with an associated significant morbidity. Our study aimed to identify a subgroup of patients with higher odds of harboring benign tumors, who would hence benefit from further diagnostic examinations (such as renal biopsy) or active surveillance. We performed a retrospective review of the medical data, including pathology results, of patients undergoing surgery for solid renal masses that were suspected to be RCCs (for a total sample of 307 patients). Owing to the widespread use of common and non-invasive imaging techniques, the incidental diagnosis of kidney tumors has become increasingly common. Considering that a non-negligible rate of these tumors is found to be benign after surgery at pathological examination, it is crucial to identify features that can correctly diagnose a mass as benign or not. According to our study results, female sex and tumor size ≤ 3 cm were independent predictors of benign disease. Contrary to that demonstrated by other authors, increasing patient age was also positively linked to a greater risk of malign pathology.
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spelling pubmed-103767572023-07-29 “Could Patient Age and Gender, along with Mass Size, Be Predictive Factors for Benign Kidney Tumors?”: A Retrospective Analysis of 307 Consecutive Single Renal Masses Treated with Partial or Radical Nephrectomy Baio, Raffaele Molisso, Giovanni Caruana, Christian Di Mauro, Umberto Intilla, Olivier Pane, Umberto D’Angelo, Costantino Campitelli, Antonio Pentimalli, Francesca Sanseverino, Roberto Bioengineering (Basel) Article Due to the increased use of common and non-invasive abdominal imaging techniques over the last few decades, the diagnosis of about 60% of renal tumors is incidental. Contrast-enhancing renal nodules on computed tomography are diagnosed as malignant tumors, which are often removed surgically without first performing a biopsy. Most kidney nodules are renal cell carcinoma (RCC) after surgical treatment, but a non-negligible rate of these nodules may be benign on final pathology; as a result, patients undergo unnecessary surgery with an associated significant morbidity. Our study aimed to identify a subgroup of patients with higher odds of harboring benign tumors, who would hence benefit from further diagnostic examinations (such as renal biopsy) or active surveillance. We performed a retrospective review of the medical data, including pathology results, of patients undergoing surgery for solid renal masses that were suspected to be RCCs (for a total sample of 307 patients). Owing to the widespread use of common and non-invasive imaging techniques, the incidental diagnosis of kidney tumors has become increasingly common. Considering that a non-negligible rate of these tumors is found to be benign after surgery at pathological examination, it is crucial to identify features that can correctly diagnose a mass as benign or not. According to our study results, female sex and tumor size ≤ 3 cm were independent predictors of benign disease. Contrary to that demonstrated by other authors, increasing patient age was also positively linked to a greater risk of malign pathology. MDPI 2023-07-03 /pmc/articles/PMC10376757/ /pubmed/37508821 http://dx.doi.org/10.3390/bioengineering10070794 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Baio, Raffaele
Molisso, Giovanni
Caruana, Christian
Di Mauro, Umberto
Intilla, Olivier
Pane, Umberto
D’Angelo, Costantino
Campitelli, Antonio
Pentimalli, Francesca
Sanseverino, Roberto
“Could Patient Age and Gender, along with Mass Size, Be Predictive Factors for Benign Kidney Tumors?”: A Retrospective Analysis of 307 Consecutive Single Renal Masses Treated with Partial or Radical Nephrectomy
title “Could Patient Age and Gender, along with Mass Size, Be Predictive Factors for Benign Kidney Tumors?”: A Retrospective Analysis of 307 Consecutive Single Renal Masses Treated with Partial or Radical Nephrectomy
title_full “Could Patient Age and Gender, along with Mass Size, Be Predictive Factors for Benign Kidney Tumors?”: A Retrospective Analysis of 307 Consecutive Single Renal Masses Treated with Partial or Radical Nephrectomy
title_fullStr “Could Patient Age and Gender, along with Mass Size, Be Predictive Factors for Benign Kidney Tumors?”: A Retrospective Analysis of 307 Consecutive Single Renal Masses Treated with Partial or Radical Nephrectomy
title_full_unstemmed “Could Patient Age and Gender, along with Mass Size, Be Predictive Factors for Benign Kidney Tumors?”: A Retrospective Analysis of 307 Consecutive Single Renal Masses Treated with Partial or Radical Nephrectomy
title_short “Could Patient Age and Gender, along with Mass Size, Be Predictive Factors for Benign Kidney Tumors?”: A Retrospective Analysis of 307 Consecutive Single Renal Masses Treated with Partial or Radical Nephrectomy
title_sort “could patient age and gender, along with mass size, be predictive factors for benign kidney tumors?”: a retrospective analysis of 307 consecutive single renal masses treated with partial or radical nephrectomy
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10376757/
https://www.ncbi.nlm.nih.gov/pubmed/37508821
http://dx.doi.org/10.3390/bioengineering10070794
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