Outcome of BCG Vaccination in ADA-SCID Patients: A 12-Patient Series

Vaccination with Bacillus Calmette–Guérin (BCG) can be harmful to patients with combined primary immunodeficiencies. We report the outcome of BCG vaccination in a series of twelve patients affected by adenosine deaminase deficiency (ADA-SCID). BCG vaccination resulted in a very high incidence of com...

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Autores principales: Canarutto, Daniele, Oltolini, Chiara, Barzaghi, Federica, Calbi, Valeria, Migliavacca, Maddalena, Tucci, Francesca, Gallo, Vera, Consiglieri, Giulia, Ferrua, Francesca, Recupero, Salvatore, Cervi, Maria Celia, Al-Mousa, Hamoud, Pituch-Noworolska, Anna, Tassan Din, Chiara, Scarpellini, Paolo, Silvani, Paolo, Fossati, Claudia, Casiraghi, Miriam, Cirillo, Daniela Maria, Castagna, Antonella, Bernardo, Maria Ester, Aiuti, Alessandro, Cicalese, Maria Pia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10376767/
https://www.ncbi.nlm.nih.gov/pubmed/37509449
http://dx.doi.org/10.3390/biomedicines11071809
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author Canarutto, Daniele
Oltolini, Chiara
Barzaghi, Federica
Calbi, Valeria
Migliavacca, Maddalena
Tucci, Francesca
Gallo, Vera
Consiglieri, Giulia
Ferrua, Francesca
Recupero, Salvatore
Cervi, Maria Celia
Al-Mousa, Hamoud
Pituch-Noworolska, Anna
Tassan Din, Chiara
Scarpellini, Paolo
Silvani, Paolo
Fossati, Claudia
Casiraghi, Miriam
Cirillo, Daniela Maria
Castagna, Antonella
Bernardo, Maria Ester
Aiuti, Alessandro
Cicalese, Maria Pia
author_facet Canarutto, Daniele
Oltolini, Chiara
Barzaghi, Federica
Calbi, Valeria
Migliavacca, Maddalena
Tucci, Francesca
Gallo, Vera
Consiglieri, Giulia
Ferrua, Francesca
Recupero, Salvatore
Cervi, Maria Celia
Al-Mousa, Hamoud
Pituch-Noworolska, Anna
Tassan Din, Chiara
Scarpellini, Paolo
Silvani, Paolo
Fossati, Claudia
Casiraghi, Miriam
Cirillo, Daniela Maria
Castagna, Antonella
Bernardo, Maria Ester
Aiuti, Alessandro
Cicalese, Maria Pia
author_sort Canarutto, Daniele
collection PubMed
description Vaccination with Bacillus Calmette–Guérin (BCG) can be harmful to patients with combined primary immunodeficiencies. We report the outcome of BCG vaccination in a series of twelve patients affected by adenosine deaminase deficiency (ADA-SCID). BCG vaccination resulted in a very high incidence of complications due to uncontrolled replication of the mycobacterium. All patients who developed BCG-related disease were treated successfully and remained free from recurrence of disease. We recommend the prompt initiation of enzyme replacement therapy and secondary prophylaxis to reduce the risk of BCG-related complications in ADA-SCID patients.
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spelling pubmed-103767672023-07-29 Outcome of BCG Vaccination in ADA-SCID Patients: A 12-Patient Series Canarutto, Daniele Oltolini, Chiara Barzaghi, Federica Calbi, Valeria Migliavacca, Maddalena Tucci, Francesca Gallo, Vera Consiglieri, Giulia Ferrua, Francesca Recupero, Salvatore Cervi, Maria Celia Al-Mousa, Hamoud Pituch-Noworolska, Anna Tassan Din, Chiara Scarpellini, Paolo Silvani, Paolo Fossati, Claudia Casiraghi, Miriam Cirillo, Daniela Maria Castagna, Antonella Bernardo, Maria Ester Aiuti, Alessandro Cicalese, Maria Pia Biomedicines Article Vaccination with Bacillus Calmette–Guérin (BCG) can be harmful to patients with combined primary immunodeficiencies. We report the outcome of BCG vaccination in a series of twelve patients affected by adenosine deaminase deficiency (ADA-SCID). BCG vaccination resulted in a very high incidence of complications due to uncontrolled replication of the mycobacterium. All patients who developed BCG-related disease were treated successfully and remained free from recurrence of disease. We recommend the prompt initiation of enzyme replacement therapy and secondary prophylaxis to reduce the risk of BCG-related complications in ADA-SCID patients. MDPI 2023-06-24 /pmc/articles/PMC10376767/ /pubmed/37509449 http://dx.doi.org/10.3390/biomedicines11071809 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Canarutto, Daniele
Oltolini, Chiara
Barzaghi, Federica
Calbi, Valeria
Migliavacca, Maddalena
Tucci, Francesca
Gallo, Vera
Consiglieri, Giulia
Ferrua, Francesca
Recupero, Salvatore
Cervi, Maria Celia
Al-Mousa, Hamoud
Pituch-Noworolska, Anna
Tassan Din, Chiara
Scarpellini, Paolo
Silvani, Paolo
Fossati, Claudia
Casiraghi, Miriam
Cirillo, Daniela Maria
Castagna, Antonella
Bernardo, Maria Ester
Aiuti, Alessandro
Cicalese, Maria Pia
Outcome of BCG Vaccination in ADA-SCID Patients: A 12-Patient Series
title Outcome of BCG Vaccination in ADA-SCID Patients: A 12-Patient Series
title_full Outcome of BCG Vaccination in ADA-SCID Patients: A 12-Patient Series
title_fullStr Outcome of BCG Vaccination in ADA-SCID Patients: A 12-Patient Series
title_full_unstemmed Outcome of BCG Vaccination in ADA-SCID Patients: A 12-Patient Series
title_short Outcome of BCG Vaccination in ADA-SCID Patients: A 12-Patient Series
title_sort outcome of bcg vaccination in ada-scid patients: a 12-patient series
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10376767/
https://www.ncbi.nlm.nih.gov/pubmed/37509449
http://dx.doi.org/10.3390/biomedicines11071809
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