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Risk Factors Associated with the Development of Hospital-Acquired Infections in Hospitalized Patients with Severe COVID-19

Recognition of risk factors for hospital-acquired infections (HAI) in patients with COVID-19 is warranted. We aimed to describe factors associated with the development of HAI in patients with severe COVID-19. We conducted a retrospective cohort study including all adult patients admitted with severe...

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Autores principales: Solís-Huerta, Fernando, Martinez-Guerra, Bernardo Alfonso, Roman-Montes, Carla Marina, Tamez-Torres, Karla Maria, Rajme-Lopez, Sandra, Ortíz-Conchi, Narciso, López-García, Norma Irene, Villalobos-Zapata, Guadalupe Yvonne, Rangel-Cordero, Andrea, Santiago-Cruz, Janet, Xancal-Salvador, Luis Fernando, Méndez-Ramos, Steven, Ochoa-Hein, Eric, Galindo-Fraga, Arturo, Ponce-de-Leon, Alfredo, Gonzalez-Lara, Maria Fernanda, Sifuentes-Osornio, Jose
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10376785/
https://www.ncbi.nlm.nih.gov/pubmed/37508204
http://dx.doi.org/10.3390/antibiotics12071108
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author Solís-Huerta, Fernando
Martinez-Guerra, Bernardo Alfonso
Roman-Montes, Carla Marina
Tamez-Torres, Karla Maria
Rajme-Lopez, Sandra
Ortíz-Conchi, Narciso
López-García, Norma Irene
Villalobos-Zapata, Guadalupe Yvonne
Rangel-Cordero, Andrea
Santiago-Cruz, Janet
Xancal-Salvador, Luis Fernando
Méndez-Ramos, Steven
Ochoa-Hein, Eric
Galindo-Fraga, Arturo
Ponce-de-Leon, Alfredo
Gonzalez-Lara, Maria Fernanda
Sifuentes-Osornio, Jose
author_facet Solís-Huerta, Fernando
Martinez-Guerra, Bernardo Alfonso
Roman-Montes, Carla Marina
Tamez-Torres, Karla Maria
Rajme-Lopez, Sandra
Ortíz-Conchi, Narciso
López-García, Norma Irene
Villalobos-Zapata, Guadalupe Yvonne
Rangel-Cordero, Andrea
Santiago-Cruz, Janet
Xancal-Salvador, Luis Fernando
Méndez-Ramos, Steven
Ochoa-Hein, Eric
Galindo-Fraga, Arturo
Ponce-de-Leon, Alfredo
Gonzalez-Lara, Maria Fernanda
Sifuentes-Osornio, Jose
author_sort Solís-Huerta, Fernando
collection PubMed
description Recognition of risk factors for hospital-acquired infections (HAI) in patients with COVID-19 is warranted. We aimed to describe factors associated with the development of HAI in patients with severe COVID-19. We conducted a retrospective cohort study including all adult patients admitted with severe COVID-19 between March 2020 and November 2020. The primary outcome was HAI development. Bivariate and multiple logistic regression models were constructed. Among 1540 patients, HAI occurred in 221 (14%). A total of 299 episodes of HAI were registered. The most common HAI were hospital-acquired/ventilation-associated pneumonia (173 episodes) and primary bloodstream infection (66 episodes). Death occurred in 387 (35%) patients and was more frequent in patients with HAI (38% vs. 23%, p < 0.01). Early mechanical ventilation (aOR 18.78, 95% CI 12.56–28.07), chronic kidney disease (aOR 3.41, 95% CI 1.4–8.27), use of corticosteroids (aOR 2.95, 95% CI 1.92–4.53) and tocilizumab (aOR 2.68, 95% CI 1.38–5.22), age ≥ 60 years (aOR 1.91, 95% CI 1.27–2.88), male sex (aOR 1.52, 95% CI 1.03–2.24), and obesity (aOR 1.49, 95% CI 1.03–2.15) were associated with HAI. In patients with severe COVID-19, mechanical ventilation within the first 24 h upon admission, chronic kidney disease, use of corticosteroids, use of tocilizumab, age ≥ 60 years, male sex, and obesity were associated with a higher risk of HAI.
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spelling pubmed-103767852023-07-29 Risk Factors Associated with the Development of Hospital-Acquired Infections in Hospitalized Patients with Severe COVID-19 Solís-Huerta, Fernando Martinez-Guerra, Bernardo Alfonso Roman-Montes, Carla Marina Tamez-Torres, Karla Maria Rajme-Lopez, Sandra Ortíz-Conchi, Narciso López-García, Norma Irene Villalobos-Zapata, Guadalupe Yvonne Rangel-Cordero, Andrea Santiago-Cruz, Janet Xancal-Salvador, Luis Fernando Méndez-Ramos, Steven Ochoa-Hein, Eric Galindo-Fraga, Arturo Ponce-de-Leon, Alfredo Gonzalez-Lara, Maria Fernanda Sifuentes-Osornio, Jose Antibiotics (Basel) Article Recognition of risk factors for hospital-acquired infections (HAI) in patients with COVID-19 is warranted. We aimed to describe factors associated with the development of HAI in patients with severe COVID-19. We conducted a retrospective cohort study including all adult patients admitted with severe COVID-19 between March 2020 and November 2020. The primary outcome was HAI development. Bivariate and multiple logistic regression models were constructed. Among 1540 patients, HAI occurred in 221 (14%). A total of 299 episodes of HAI were registered. The most common HAI were hospital-acquired/ventilation-associated pneumonia (173 episodes) and primary bloodstream infection (66 episodes). Death occurred in 387 (35%) patients and was more frequent in patients with HAI (38% vs. 23%, p < 0.01). Early mechanical ventilation (aOR 18.78, 95% CI 12.56–28.07), chronic kidney disease (aOR 3.41, 95% CI 1.4–8.27), use of corticosteroids (aOR 2.95, 95% CI 1.92–4.53) and tocilizumab (aOR 2.68, 95% CI 1.38–5.22), age ≥ 60 years (aOR 1.91, 95% CI 1.27–2.88), male sex (aOR 1.52, 95% CI 1.03–2.24), and obesity (aOR 1.49, 95% CI 1.03–2.15) were associated with HAI. In patients with severe COVID-19, mechanical ventilation within the first 24 h upon admission, chronic kidney disease, use of corticosteroids, use of tocilizumab, age ≥ 60 years, male sex, and obesity were associated with a higher risk of HAI. MDPI 2023-06-27 /pmc/articles/PMC10376785/ /pubmed/37508204 http://dx.doi.org/10.3390/antibiotics12071108 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Solís-Huerta, Fernando
Martinez-Guerra, Bernardo Alfonso
Roman-Montes, Carla Marina
Tamez-Torres, Karla Maria
Rajme-Lopez, Sandra
Ortíz-Conchi, Narciso
López-García, Norma Irene
Villalobos-Zapata, Guadalupe Yvonne
Rangel-Cordero, Andrea
Santiago-Cruz, Janet
Xancal-Salvador, Luis Fernando
Méndez-Ramos, Steven
Ochoa-Hein, Eric
Galindo-Fraga, Arturo
Ponce-de-Leon, Alfredo
Gonzalez-Lara, Maria Fernanda
Sifuentes-Osornio, Jose
Risk Factors Associated with the Development of Hospital-Acquired Infections in Hospitalized Patients with Severe COVID-19
title Risk Factors Associated with the Development of Hospital-Acquired Infections in Hospitalized Patients with Severe COVID-19
title_full Risk Factors Associated with the Development of Hospital-Acquired Infections in Hospitalized Patients with Severe COVID-19
title_fullStr Risk Factors Associated with the Development of Hospital-Acquired Infections in Hospitalized Patients with Severe COVID-19
title_full_unstemmed Risk Factors Associated with the Development of Hospital-Acquired Infections in Hospitalized Patients with Severe COVID-19
title_short Risk Factors Associated with the Development of Hospital-Acquired Infections in Hospitalized Patients with Severe COVID-19
title_sort risk factors associated with the development of hospital-acquired infections in hospitalized patients with severe covid-19
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10376785/
https://www.ncbi.nlm.nih.gov/pubmed/37508204
http://dx.doi.org/10.3390/antibiotics12071108
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