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Risk Factors Associated with the Development of Hospital-Acquired Infections in Hospitalized Patients with Severe COVID-19
Recognition of risk factors for hospital-acquired infections (HAI) in patients with COVID-19 is warranted. We aimed to describe factors associated with the development of HAI in patients with severe COVID-19. We conducted a retrospective cohort study including all adult patients admitted with severe...
Autores principales: | , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10376785/ https://www.ncbi.nlm.nih.gov/pubmed/37508204 http://dx.doi.org/10.3390/antibiotics12071108 |
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author | Solís-Huerta, Fernando Martinez-Guerra, Bernardo Alfonso Roman-Montes, Carla Marina Tamez-Torres, Karla Maria Rajme-Lopez, Sandra Ortíz-Conchi, Narciso López-García, Norma Irene Villalobos-Zapata, Guadalupe Yvonne Rangel-Cordero, Andrea Santiago-Cruz, Janet Xancal-Salvador, Luis Fernando Méndez-Ramos, Steven Ochoa-Hein, Eric Galindo-Fraga, Arturo Ponce-de-Leon, Alfredo Gonzalez-Lara, Maria Fernanda Sifuentes-Osornio, Jose |
author_facet | Solís-Huerta, Fernando Martinez-Guerra, Bernardo Alfonso Roman-Montes, Carla Marina Tamez-Torres, Karla Maria Rajme-Lopez, Sandra Ortíz-Conchi, Narciso López-García, Norma Irene Villalobos-Zapata, Guadalupe Yvonne Rangel-Cordero, Andrea Santiago-Cruz, Janet Xancal-Salvador, Luis Fernando Méndez-Ramos, Steven Ochoa-Hein, Eric Galindo-Fraga, Arturo Ponce-de-Leon, Alfredo Gonzalez-Lara, Maria Fernanda Sifuentes-Osornio, Jose |
author_sort | Solís-Huerta, Fernando |
collection | PubMed |
description | Recognition of risk factors for hospital-acquired infections (HAI) in patients with COVID-19 is warranted. We aimed to describe factors associated with the development of HAI in patients with severe COVID-19. We conducted a retrospective cohort study including all adult patients admitted with severe COVID-19 between March 2020 and November 2020. The primary outcome was HAI development. Bivariate and multiple logistic regression models were constructed. Among 1540 patients, HAI occurred in 221 (14%). A total of 299 episodes of HAI were registered. The most common HAI were hospital-acquired/ventilation-associated pneumonia (173 episodes) and primary bloodstream infection (66 episodes). Death occurred in 387 (35%) patients and was more frequent in patients with HAI (38% vs. 23%, p < 0.01). Early mechanical ventilation (aOR 18.78, 95% CI 12.56–28.07), chronic kidney disease (aOR 3.41, 95% CI 1.4–8.27), use of corticosteroids (aOR 2.95, 95% CI 1.92–4.53) and tocilizumab (aOR 2.68, 95% CI 1.38–5.22), age ≥ 60 years (aOR 1.91, 95% CI 1.27–2.88), male sex (aOR 1.52, 95% CI 1.03–2.24), and obesity (aOR 1.49, 95% CI 1.03–2.15) were associated with HAI. In patients with severe COVID-19, mechanical ventilation within the first 24 h upon admission, chronic kidney disease, use of corticosteroids, use of tocilizumab, age ≥ 60 years, male sex, and obesity were associated with a higher risk of HAI. |
format | Online Article Text |
id | pubmed-10376785 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-103767852023-07-29 Risk Factors Associated with the Development of Hospital-Acquired Infections in Hospitalized Patients with Severe COVID-19 Solís-Huerta, Fernando Martinez-Guerra, Bernardo Alfonso Roman-Montes, Carla Marina Tamez-Torres, Karla Maria Rajme-Lopez, Sandra Ortíz-Conchi, Narciso López-García, Norma Irene Villalobos-Zapata, Guadalupe Yvonne Rangel-Cordero, Andrea Santiago-Cruz, Janet Xancal-Salvador, Luis Fernando Méndez-Ramos, Steven Ochoa-Hein, Eric Galindo-Fraga, Arturo Ponce-de-Leon, Alfredo Gonzalez-Lara, Maria Fernanda Sifuentes-Osornio, Jose Antibiotics (Basel) Article Recognition of risk factors for hospital-acquired infections (HAI) in patients with COVID-19 is warranted. We aimed to describe factors associated with the development of HAI in patients with severe COVID-19. We conducted a retrospective cohort study including all adult patients admitted with severe COVID-19 between March 2020 and November 2020. The primary outcome was HAI development. Bivariate and multiple logistic regression models were constructed. Among 1540 patients, HAI occurred in 221 (14%). A total of 299 episodes of HAI were registered. The most common HAI were hospital-acquired/ventilation-associated pneumonia (173 episodes) and primary bloodstream infection (66 episodes). Death occurred in 387 (35%) patients and was more frequent in patients with HAI (38% vs. 23%, p < 0.01). Early mechanical ventilation (aOR 18.78, 95% CI 12.56–28.07), chronic kidney disease (aOR 3.41, 95% CI 1.4–8.27), use of corticosteroids (aOR 2.95, 95% CI 1.92–4.53) and tocilizumab (aOR 2.68, 95% CI 1.38–5.22), age ≥ 60 years (aOR 1.91, 95% CI 1.27–2.88), male sex (aOR 1.52, 95% CI 1.03–2.24), and obesity (aOR 1.49, 95% CI 1.03–2.15) were associated with HAI. In patients with severe COVID-19, mechanical ventilation within the first 24 h upon admission, chronic kidney disease, use of corticosteroids, use of tocilizumab, age ≥ 60 years, male sex, and obesity were associated with a higher risk of HAI. MDPI 2023-06-27 /pmc/articles/PMC10376785/ /pubmed/37508204 http://dx.doi.org/10.3390/antibiotics12071108 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Solís-Huerta, Fernando Martinez-Guerra, Bernardo Alfonso Roman-Montes, Carla Marina Tamez-Torres, Karla Maria Rajme-Lopez, Sandra Ortíz-Conchi, Narciso López-García, Norma Irene Villalobos-Zapata, Guadalupe Yvonne Rangel-Cordero, Andrea Santiago-Cruz, Janet Xancal-Salvador, Luis Fernando Méndez-Ramos, Steven Ochoa-Hein, Eric Galindo-Fraga, Arturo Ponce-de-Leon, Alfredo Gonzalez-Lara, Maria Fernanda Sifuentes-Osornio, Jose Risk Factors Associated with the Development of Hospital-Acquired Infections in Hospitalized Patients with Severe COVID-19 |
title | Risk Factors Associated with the Development of Hospital-Acquired Infections in Hospitalized Patients with Severe COVID-19 |
title_full | Risk Factors Associated with the Development of Hospital-Acquired Infections in Hospitalized Patients with Severe COVID-19 |
title_fullStr | Risk Factors Associated with the Development of Hospital-Acquired Infections in Hospitalized Patients with Severe COVID-19 |
title_full_unstemmed | Risk Factors Associated with the Development of Hospital-Acquired Infections in Hospitalized Patients with Severe COVID-19 |
title_short | Risk Factors Associated with the Development of Hospital-Acquired Infections in Hospitalized Patients with Severe COVID-19 |
title_sort | risk factors associated with the development of hospital-acquired infections in hospitalized patients with severe covid-19 |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10376785/ https://www.ncbi.nlm.nih.gov/pubmed/37508204 http://dx.doi.org/10.3390/antibiotics12071108 |
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