Cargando…

Effects of Tannic Acid Supplementation on the Intestinal Health, Immunity, and Antioxidant Function of Broilers Challenged with Necrotic Enteritis

Clostridium perfringens causes necrotic enteritis (NE) after proliferation in the intestine of poultry, resulting in considerable losses to the poultry industry. This study aimed to investigate the impact of tannic acid on the antioxidant, immunity, and gut health of broilers with NE. In the experim...

Descripción completa

Detalles Bibliográficos
Autores principales: Xu, Huiping, Zhang, Xiaodan, Li, Peng, Luo, Yimeng, Fu, Jianyang, Gong, Lu, Lv, Zengpeng, Guo, Yuming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10376868/
https://www.ncbi.nlm.nih.gov/pubmed/37508014
http://dx.doi.org/10.3390/antiox12071476
_version_ 1785079379577012224
author Xu, Huiping
Zhang, Xiaodan
Li, Peng
Luo, Yimeng
Fu, Jianyang
Gong, Lu
Lv, Zengpeng
Guo, Yuming
author_facet Xu, Huiping
Zhang, Xiaodan
Li, Peng
Luo, Yimeng
Fu, Jianyang
Gong, Lu
Lv, Zengpeng
Guo, Yuming
author_sort Xu, Huiping
collection PubMed
description Clostridium perfringens causes necrotic enteritis (NE) after proliferation in the intestine of poultry, resulting in considerable losses to the poultry industry. This study aimed to investigate the impact of tannic acid on the antioxidant, immunity, and gut health of broilers with NE. In the experiment, 630 one-day-old Cobb500 male chicks were randomly divided into six treatment groups, with seven replicate cages and with fifteen birds in each cage. The treatment groups were as follows: control group (NC), challenged group (PC), and challenged NE chickens treated with 250, 500, 750, and 1000 mg/kg tannic acid (PTA1, PTA2, PTA3, and PTA4, respectively). To induce NE, coccidia vaccine and Clostridium perfringens were administered on day 19 and days 22–28, respectively. Indexes related to antioxidant, immune, and intestinal health were measured on days 28 and 35. During the infection period, we observed significant increases in fecal water content, D-LA, TNF-α, and malondialdehyde concentrations (p < 0.05). Conversely, significant decreases were noted in chyme pH and in T-AOC, IL-4, and IL-10 concentrations (p < 0.05). The addition of tannic acid exhibited a linear decrease in fecal water content and TNF-α concentration (p < 0.05). Furthermore, tannic acid supplementation resulted in a quadratic curve decrease in D-LA concentration and linear increases in T-AOC, IL-4, and IL-10 (p < 0.05). Cecal microbiological analysis revealed that Ruminococcaceae and Butyricimona were dominant in PTA3. In conclusion, the dietary addition of tannic acid may reduce the negative effects of NE by increasing antioxidant and anti-inflammatory capacity, improving the intestinal barrier, and regulating the intestinal flora.
format Online
Article
Text
id pubmed-10376868
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-103768682023-07-29 Effects of Tannic Acid Supplementation on the Intestinal Health, Immunity, and Antioxidant Function of Broilers Challenged with Necrotic Enteritis Xu, Huiping Zhang, Xiaodan Li, Peng Luo, Yimeng Fu, Jianyang Gong, Lu Lv, Zengpeng Guo, Yuming Antioxidants (Basel) Article Clostridium perfringens causes necrotic enteritis (NE) after proliferation in the intestine of poultry, resulting in considerable losses to the poultry industry. This study aimed to investigate the impact of tannic acid on the antioxidant, immunity, and gut health of broilers with NE. In the experiment, 630 one-day-old Cobb500 male chicks were randomly divided into six treatment groups, with seven replicate cages and with fifteen birds in each cage. The treatment groups were as follows: control group (NC), challenged group (PC), and challenged NE chickens treated with 250, 500, 750, and 1000 mg/kg tannic acid (PTA1, PTA2, PTA3, and PTA4, respectively). To induce NE, coccidia vaccine and Clostridium perfringens were administered on day 19 and days 22–28, respectively. Indexes related to antioxidant, immune, and intestinal health were measured on days 28 and 35. During the infection period, we observed significant increases in fecal water content, D-LA, TNF-α, and malondialdehyde concentrations (p < 0.05). Conversely, significant decreases were noted in chyme pH and in T-AOC, IL-4, and IL-10 concentrations (p < 0.05). The addition of tannic acid exhibited a linear decrease in fecal water content and TNF-α concentration (p < 0.05). Furthermore, tannic acid supplementation resulted in a quadratic curve decrease in D-LA concentration and linear increases in T-AOC, IL-4, and IL-10 (p < 0.05). Cecal microbiological analysis revealed that Ruminococcaceae and Butyricimona were dominant in PTA3. In conclusion, the dietary addition of tannic acid may reduce the negative effects of NE by increasing antioxidant and anti-inflammatory capacity, improving the intestinal barrier, and regulating the intestinal flora. MDPI 2023-07-24 /pmc/articles/PMC10376868/ /pubmed/37508014 http://dx.doi.org/10.3390/antiox12071476 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Xu, Huiping
Zhang, Xiaodan
Li, Peng
Luo, Yimeng
Fu, Jianyang
Gong, Lu
Lv, Zengpeng
Guo, Yuming
Effects of Tannic Acid Supplementation on the Intestinal Health, Immunity, and Antioxidant Function of Broilers Challenged with Necrotic Enteritis
title Effects of Tannic Acid Supplementation on the Intestinal Health, Immunity, and Antioxidant Function of Broilers Challenged with Necrotic Enteritis
title_full Effects of Tannic Acid Supplementation on the Intestinal Health, Immunity, and Antioxidant Function of Broilers Challenged with Necrotic Enteritis
title_fullStr Effects of Tannic Acid Supplementation on the Intestinal Health, Immunity, and Antioxidant Function of Broilers Challenged with Necrotic Enteritis
title_full_unstemmed Effects of Tannic Acid Supplementation on the Intestinal Health, Immunity, and Antioxidant Function of Broilers Challenged with Necrotic Enteritis
title_short Effects of Tannic Acid Supplementation on the Intestinal Health, Immunity, and Antioxidant Function of Broilers Challenged with Necrotic Enteritis
title_sort effects of tannic acid supplementation on the intestinal health, immunity, and antioxidant function of broilers challenged with necrotic enteritis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10376868/
https://www.ncbi.nlm.nih.gov/pubmed/37508014
http://dx.doi.org/10.3390/antiox12071476
work_keys_str_mv AT xuhuiping effectsoftannicacidsupplementationontheintestinalhealthimmunityandantioxidantfunctionofbroilerschallengedwithnecroticenteritis
AT zhangxiaodan effectsoftannicacidsupplementationontheintestinalhealthimmunityandantioxidantfunctionofbroilerschallengedwithnecroticenteritis
AT lipeng effectsoftannicacidsupplementationontheintestinalhealthimmunityandantioxidantfunctionofbroilerschallengedwithnecroticenteritis
AT luoyimeng effectsoftannicacidsupplementationontheintestinalhealthimmunityandantioxidantfunctionofbroilerschallengedwithnecroticenteritis
AT fujianyang effectsoftannicacidsupplementationontheintestinalhealthimmunityandantioxidantfunctionofbroilerschallengedwithnecroticenteritis
AT gonglu effectsoftannicacidsupplementationontheintestinalhealthimmunityandantioxidantfunctionofbroilerschallengedwithnecroticenteritis
AT lvzengpeng effectsoftannicacidsupplementationontheintestinalhealthimmunityandantioxidantfunctionofbroilerschallengedwithnecroticenteritis
AT guoyuming effectsoftannicacidsupplementationontheintestinalhealthimmunityandantioxidantfunctionofbroilerschallengedwithnecroticenteritis