Bivalent non-human gal-α1-3-gal glycan epitopes in the Fc region of a monoclonal antibody model can be recognized by anti-Gal-α1-3-Gal IgE antibodies

Monoclonal antibody (mAb) production using non-human cells can introduce non-human glycan epitopes including terminal galactosyl-α1–3-galactose (α1–3-Gal) moieties. Cetuximab is a commercial mAb associated with causing anaphylaxis in some patients due to the binding of endogenous anti-α1–3-Gal IgE t...

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Detalles Bibliográficos
Autores principales: Hatfield, Grayson, Tepliakova, Lioudmila, Tran, Jessica, Lu, Huixin, Gilbert, Michel, Tam, Roger Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2023
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10376915/
https://www.ncbi.nlm.nih.gov/pubmed/37497986
http://dx.doi.org/10.1080/19420862.2023.2239405

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10376915/
https://www.ncbi.nlm.nih.gov/pubmed/37497986
http://dx.doi.org/10.1080/19420862.2023.2239405

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