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Unveiling and harnessing the human gut microbiome in the rising burden of non-communicable diseases during urbanization
The world is witnessing a global increase in the urban population, particularly in developing Asian and African countries. Concomitantly, the global burden of non-communicable diseases (NCDs) is rising, markedly associated with the changing landscape of lifestyle and environment during urbanization....
Autores principales: | , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Taylor & Francis
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10376922/ https://www.ncbi.nlm.nih.gov/pubmed/37498052 http://dx.doi.org/10.1080/19490976.2023.2237645 |
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author | Huang, Ziyu Li, Yue Park, Heekuk Ho, Martin Bhardwaj, Kanchan Sugimura, Naoki Lee, Hye Won Meng, Huicui Ebert, Matthias P. Chao, Kang Burgermeister, Elke Bhatt, Aadra P. Shetty, Sudarshan A. Li, Kai Wen, Weiping Zuo, Tao |
author_facet | Huang, Ziyu Li, Yue Park, Heekuk Ho, Martin Bhardwaj, Kanchan Sugimura, Naoki Lee, Hye Won Meng, Huicui Ebert, Matthias P. Chao, Kang Burgermeister, Elke Bhatt, Aadra P. Shetty, Sudarshan A. Li, Kai Wen, Weiping Zuo, Tao |
author_sort | Huang, Ziyu |
collection | PubMed |
description | The world is witnessing a global increase in the urban population, particularly in developing Asian and African countries. Concomitantly, the global burden of non-communicable diseases (NCDs) is rising, markedly associated with the changing landscape of lifestyle and environment during urbanization. Accumulating studies have revealed the role of the gut microbiome in regulating the immune and metabolic homeostasis of the host, which potentially bridges external factors to the host (patho-)physiology. In this review, we discuss the rising incidences of NCDs during urbanization and their links to the compositional and functional dysbiosis of the gut microbiome. In particular, we elucidate the effects of urbanization-associated factors (hygiene/pollution, urbanized diet, lifestyles, the use of antibiotics, and early life exposure) on the gut microbiome underlying the pathogenesis of NCDs. We also discuss the potential and feasibility of microbiome-inspired and microbiome-targeted approaches as novel avenues to counteract NCDs, including fecal microbiota transplantation, diet modulation, probiotics, postbiotics, synbiotics, celobiotics, and precision antibiotics. |
format | Online Article Text |
id | pubmed-10376922 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Taylor & Francis |
record_format | MEDLINE/PubMed |
spelling | pubmed-103769222023-07-29 Unveiling and harnessing the human gut microbiome in the rising burden of non-communicable diseases during urbanization Huang, Ziyu Li, Yue Park, Heekuk Ho, Martin Bhardwaj, Kanchan Sugimura, Naoki Lee, Hye Won Meng, Huicui Ebert, Matthias P. Chao, Kang Burgermeister, Elke Bhatt, Aadra P. Shetty, Sudarshan A. Li, Kai Wen, Weiping Zuo, Tao Gut Microbes Review The world is witnessing a global increase in the urban population, particularly in developing Asian and African countries. Concomitantly, the global burden of non-communicable diseases (NCDs) is rising, markedly associated with the changing landscape of lifestyle and environment during urbanization. Accumulating studies have revealed the role of the gut microbiome in regulating the immune and metabolic homeostasis of the host, which potentially bridges external factors to the host (patho-)physiology. In this review, we discuss the rising incidences of NCDs during urbanization and their links to the compositional and functional dysbiosis of the gut microbiome. In particular, we elucidate the effects of urbanization-associated factors (hygiene/pollution, urbanized diet, lifestyles, the use of antibiotics, and early life exposure) on the gut microbiome underlying the pathogenesis of NCDs. We also discuss the potential and feasibility of microbiome-inspired and microbiome-targeted approaches as novel avenues to counteract NCDs, including fecal microbiota transplantation, diet modulation, probiotics, postbiotics, synbiotics, celobiotics, and precision antibiotics. Taylor & Francis 2023-07-27 /pmc/articles/PMC10376922/ /pubmed/37498052 http://dx.doi.org/10.1080/19490976.2023.2237645 Text en © 2023 The Author(s). Published with license by Taylor & Francis Group, LLC. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The terms on which this article has been published allow the posting of the Accepted Manuscript in a repository by the author(s) or with their consent. |
spellingShingle | Review Huang, Ziyu Li, Yue Park, Heekuk Ho, Martin Bhardwaj, Kanchan Sugimura, Naoki Lee, Hye Won Meng, Huicui Ebert, Matthias P. Chao, Kang Burgermeister, Elke Bhatt, Aadra P. Shetty, Sudarshan A. Li, Kai Wen, Weiping Zuo, Tao Unveiling and harnessing the human gut microbiome in the rising burden of non-communicable diseases during urbanization |
title | Unveiling and harnessing the human gut microbiome in the rising burden of non-communicable diseases during urbanization |
title_full | Unveiling and harnessing the human gut microbiome in the rising burden of non-communicable diseases during urbanization |
title_fullStr | Unveiling and harnessing the human gut microbiome in the rising burden of non-communicable diseases during urbanization |
title_full_unstemmed | Unveiling and harnessing the human gut microbiome in the rising burden of non-communicable diseases during urbanization |
title_short | Unveiling and harnessing the human gut microbiome in the rising burden of non-communicable diseases during urbanization |
title_sort | unveiling and harnessing the human gut microbiome in the rising burden of non-communicable diseases during urbanization |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10376922/ https://www.ncbi.nlm.nih.gov/pubmed/37498052 http://dx.doi.org/10.1080/19490976.2023.2237645 |
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