Eosinophils, Basophils, and Neutrophils in Bullous Pemphigoid

Bullous pemphigoid (BP) is an autoimmune blistering skin disease, of which the incidence has increased in recent years. BP is characterized by circulating IgG and IgE autoantibodies against the hemidesmosomal proteins BP180 and BP230. Although autoantibodies trigger inflammatory cascades that lead t...

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Detalles Bibliográficos
Autores principales: Limberg, Maren M., Weihrauch, Tobias, Gray, Natalie, Ernst, Nancy, Hartmann, Karin, Raap, Ulrike
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10377006/
https://www.ncbi.nlm.nih.gov/pubmed/37509055
http://dx.doi.org/10.3390/biom13071019
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author Limberg, Maren M.
Weihrauch, Tobias
Gray, Natalie
Ernst, Nancy
Hartmann, Karin
Raap, Ulrike
author_facet Limberg, Maren M.
Weihrauch, Tobias
Gray, Natalie
Ernst, Nancy
Hartmann, Karin
Raap, Ulrike
author_sort Limberg, Maren M.
collection PubMed
description Bullous pemphigoid (BP) is an autoimmune blistering skin disease, of which the incidence has increased in recent years. BP is characterized by circulating IgG and IgE autoantibodies against the hemidesmosomal proteins BP180 and BP230. Although autoantibodies trigger inflammatory cascades that lead to blister formation, effector cells and cell-mediated autoimmunity must also be considered as important factors in the pathogenesis of BP. The aim of this review is to outline the current knowledge on the role of eosinophils, basophils, and neutrophils in BP.
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spelling pubmed-103770062023-07-29 Eosinophils, Basophils, and Neutrophils in Bullous Pemphigoid Limberg, Maren M. Weihrauch, Tobias Gray, Natalie Ernst, Nancy Hartmann, Karin Raap, Ulrike Biomolecules Review Bullous pemphigoid (BP) is an autoimmune blistering skin disease, of which the incidence has increased in recent years. BP is characterized by circulating IgG and IgE autoantibodies against the hemidesmosomal proteins BP180 and BP230. Although autoantibodies trigger inflammatory cascades that lead to blister formation, effector cells and cell-mediated autoimmunity must also be considered as important factors in the pathogenesis of BP. The aim of this review is to outline the current knowledge on the role of eosinophils, basophils, and neutrophils in BP. MDPI 2023-06-21 /pmc/articles/PMC10377006/ /pubmed/37509055 http://dx.doi.org/10.3390/biom13071019 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Limberg, Maren M.
Weihrauch, Tobias
Gray, Natalie
Ernst, Nancy
Hartmann, Karin
Raap, Ulrike
Eosinophils, Basophils, and Neutrophils in Bullous Pemphigoid
title Eosinophils, Basophils, and Neutrophils in Bullous Pemphigoid
title_full Eosinophils, Basophils, and Neutrophils in Bullous Pemphigoid
title_fullStr Eosinophils, Basophils, and Neutrophils in Bullous Pemphigoid
title_full_unstemmed Eosinophils, Basophils, and Neutrophils in Bullous Pemphigoid
title_short Eosinophils, Basophils, and Neutrophils in Bullous Pemphigoid
title_sort eosinophils, basophils, and neutrophils in bullous pemphigoid
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10377006/
https://www.ncbi.nlm.nih.gov/pubmed/37509055
http://dx.doi.org/10.3390/biom13071019
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