Syntheses of 25-Adamantyl-25-alkyl-2-methylidene-1α,25-dihydroxyvitamin D(3) Derivatives with Structure–Function Studies of Antagonistic and Agonistic Active Vitamin D Analogs

The active form of vitamin D(3), 1α,25-dihydroxyvitamin D(3) [1,25(OH)(2)D(3)], is a major regulator of calcium homeostasis through activation of the vitamin D receptor (VDR). We have previously synthesized vitamin D derivatives with large adamantane (AD) rings at position 24, 25, or 26 of the side...

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Detalles Bibliográficos
Autores principales: Maekawa, Kazuki, Ishizawa, Michiyasu, Ikawa, Takashi, Sajiki, Hironao, Matsumoto, Taro, Tokiwa, Hiroaki, Makishima, Makoto, Yamada, Sachiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10377034/
https://www.ncbi.nlm.nih.gov/pubmed/37509118
http://dx.doi.org/10.3390/biom13071082

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