Pediatric Central Nervous System Tumor Overview and Emerging Treatment Considerations

Pediatric central nervous system (CNS) tumors are the most common solid tumor in children, with the majority being glial in origin. These tumors are classified by the World Health Organization (WHO) as either being low grade (WHO grade 1 and 2) or high grade (WHO grade 3 and 4). Our knowledge of the...

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Autores principales: Damodharan, Sudarshawn, Puccetti, Diane
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10377074/
https://www.ncbi.nlm.nih.gov/pubmed/37509034
http://dx.doi.org/10.3390/brainsci13071106
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author Damodharan, Sudarshawn
Puccetti, Diane
author_facet Damodharan, Sudarshawn
Puccetti, Diane
author_sort Damodharan, Sudarshawn
collection PubMed
description Pediatric central nervous system (CNS) tumors are the most common solid tumor in children, with the majority being glial in origin. These tumors are classified by the World Health Organization (WHO) as either being low grade (WHO grade 1 and 2) or high grade (WHO grade 3 and 4). Our knowledge of the molecular landscape of pediatric brain tumors has advanced over the last decade, which has led to newer categorizations along with an expansion of therapeutic targets and options. In this review, we will give an overview of common CNS tumors seen in children along with a focus on treatment options and future considerations.
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spelling pubmed-103770742023-07-29 Pediatric Central Nervous System Tumor Overview and Emerging Treatment Considerations Damodharan, Sudarshawn Puccetti, Diane Brain Sci Review Pediatric central nervous system (CNS) tumors are the most common solid tumor in children, with the majority being glial in origin. These tumors are classified by the World Health Organization (WHO) as either being low grade (WHO grade 1 and 2) or high grade (WHO grade 3 and 4). Our knowledge of the molecular landscape of pediatric brain tumors has advanced over the last decade, which has led to newer categorizations along with an expansion of therapeutic targets and options. In this review, we will give an overview of common CNS tumors seen in children along with a focus on treatment options and future considerations. MDPI 2023-07-21 /pmc/articles/PMC10377074/ /pubmed/37509034 http://dx.doi.org/10.3390/brainsci13071106 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Damodharan, Sudarshawn
Puccetti, Diane
Pediatric Central Nervous System Tumor Overview and Emerging Treatment Considerations
title Pediatric Central Nervous System Tumor Overview and Emerging Treatment Considerations
title_full Pediatric Central Nervous System Tumor Overview and Emerging Treatment Considerations
title_fullStr Pediatric Central Nervous System Tumor Overview and Emerging Treatment Considerations
title_full_unstemmed Pediatric Central Nervous System Tumor Overview and Emerging Treatment Considerations
title_short Pediatric Central Nervous System Tumor Overview and Emerging Treatment Considerations
title_sort pediatric central nervous system tumor overview and emerging treatment considerations
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10377074/
https://www.ncbi.nlm.nih.gov/pubmed/37509034
http://dx.doi.org/10.3390/brainsci13071106
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