Animal Models of Ischemic Stroke with Different Forms of Middle Cerebral Artery Occlusion

Ischemic stroke is a common type of stroke that significantly affects human well-being and quality of life. In order to further characterize the pathophysiology of ischemic stroke and develop new treatment strategies, ischemic stroke models with controllable and consistent response to potential clin...

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Detalles Bibliográficos
Autores principales: Zeng, Lang, Hu, Shengqi, Zeng, Lingcheng, Chen, Rudong, Li, Hua, Yu, Jiasheng, Yang, Hongkuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10377124/
https://www.ncbi.nlm.nih.gov/pubmed/37508939
http://dx.doi.org/10.3390/brainsci13071007
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author Zeng, Lang
Hu, Shengqi
Zeng, Lingcheng
Chen, Rudong
Li, Hua
Yu, Jiasheng
Yang, Hongkuan
author_facet Zeng, Lang
Hu, Shengqi
Zeng, Lingcheng
Chen, Rudong
Li, Hua
Yu, Jiasheng
Yang, Hongkuan
author_sort Zeng, Lang
collection PubMed
description Ischemic stroke is a common type of stroke that significantly affects human well-being and quality of life. In order to further characterize the pathophysiology of ischemic stroke and develop new treatment strategies, ischemic stroke models with controllable and consistent response to potential clinical treatments are urgently needed. The middle cerebral artery occlusion (MCAO) model is currently the most widely used animal model of ischemic stroke. This review discusses various methods for constructing the MCAO model and compares their advantages and disadvantages in order to provide better approaches for studying ischemic stroke.
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spelling pubmed-103771242023-07-29 Animal Models of Ischemic Stroke with Different Forms of Middle Cerebral Artery Occlusion Zeng, Lang Hu, Shengqi Zeng, Lingcheng Chen, Rudong Li, Hua Yu, Jiasheng Yang, Hongkuan Brain Sci Review Ischemic stroke is a common type of stroke that significantly affects human well-being and quality of life. In order to further characterize the pathophysiology of ischemic stroke and develop new treatment strategies, ischemic stroke models with controllable and consistent response to potential clinical treatments are urgently needed. The middle cerebral artery occlusion (MCAO) model is currently the most widely used animal model of ischemic stroke. This review discusses various methods for constructing the MCAO model and compares their advantages and disadvantages in order to provide better approaches for studying ischemic stroke. MDPI 2023-06-29 /pmc/articles/PMC10377124/ /pubmed/37508939 http://dx.doi.org/10.3390/brainsci13071007 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Zeng, Lang
Hu, Shengqi
Zeng, Lingcheng
Chen, Rudong
Li, Hua
Yu, Jiasheng
Yang, Hongkuan
Animal Models of Ischemic Stroke with Different Forms of Middle Cerebral Artery Occlusion
title Animal Models of Ischemic Stroke with Different Forms of Middle Cerebral Artery Occlusion
title_full Animal Models of Ischemic Stroke with Different Forms of Middle Cerebral Artery Occlusion
title_fullStr Animal Models of Ischemic Stroke with Different Forms of Middle Cerebral Artery Occlusion
title_full_unstemmed Animal Models of Ischemic Stroke with Different Forms of Middle Cerebral Artery Occlusion
title_short Animal Models of Ischemic Stroke with Different Forms of Middle Cerebral Artery Occlusion
title_sort animal models of ischemic stroke with different forms of middle cerebral artery occlusion
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10377124/
https://www.ncbi.nlm.nih.gov/pubmed/37508939
http://dx.doi.org/10.3390/brainsci13071007
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