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Is Spontaneous Preterm Prelabor of Membrane Rupture Irreversible? A Review of Potentially Curative Approaches

There is still no curative treatment for the spontaneous preterm prelabor rupture of membranes (sPPROM), the main cause of premature birth. Here, we summarize the most recent methods and materials used for sealing membranes after sPPROM. A literature search was conducted between 2013 and 2023 on rep...

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Autores principales: Danciu, Bianca Mihaela, Oţelea, Marina Ruxandra, Marincaş, Marian Augustin, Niţescu, Maria, Simionescu, Anca Angela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10377155/
https://www.ncbi.nlm.nih.gov/pubmed/37509539
http://dx.doi.org/10.3390/biomedicines11071900
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author Danciu, Bianca Mihaela
Oţelea, Marina Ruxandra
Marincaş, Marian Augustin
Niţescu, Maria
Simionescu, Anca Angela
author_facet Danciu, Bianca Mihaela
Oţelea, Marina Ruxandra
Marincaş, Marian Augustin
Niţescu, Maria
Simionescu, Anca Angela
author_sort Danciu, Bianca Mihaela
collection PubMed
description There is still no curative treatment for the spontaneous preterm prelabor rupture of membranes (sPPROM), the main cause of premature birth. Here, we summarize the most recent methods and materials used for sealing membranes after sPPROM. A literature search was conducted between 2013 and 2023 on reported newborns after membranes were sealed or on animal or tissue culture models. Fourteen studies describing the outcomes after using an amniopatch, an immunologic sealant, or a mechanical cervical adapter were included. According to these studies, an increase in the volume of amniotic fluid and the lack of chorioamnionitis demonstrate a favorable neonatal outcome, with a lower incidence of respiratory distress syndrome and early neonatal sepsis, even if sealing is not complete and stable. In vivo and in vitro models demonstrated that amniotic stem cells, in combination with amniocytes, can spontaneously repair small defects; because of the heterogenicity of the data, it is too early to draw a thoughtful conclusion. Future therapies should focus on materials and methods for sealing fetal membranes that are biocompatible, absorbable, available, easy to apply, and easily adherent to the fetal membrane.
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spelling pubmed-103771552023-07-29 Is Spontaneous Preterm Prelabor of Membrane Rupture Irreversible? A Review of Potentially Curative Approaches Danciu, Bianca Mihaela Oţelea, Marina Ruxandra Marincaş, Marian Augustin Niţescu, Maria Simionescu, Anca Angela Biomedicines Systematic Review There is still no curative treatment for the spontaneous preterm prelabor rupture of membranes (sPPROM), the main cause of premature birth. Here, we summarize the most recent methods and materials used for sealing membranes after sPPROM. A literature search was conducted between 2013 and 2023 on reported newborns after membranes were sealed or on animal or tissue culture models. Fourteen studies describing the outcomes after using an amniopatch, an immunologic sealant, or a mechanical cervical adapter were included. According to these studies, an increase in the volume of amniotic fluid and the lack of chorioamnionitis demonstrate a favorable neonatal outcome, with a lower incidence of respiratory distress syndrome and early neonatal sepsis, even if sealing is not complete and stable. In vivo and in vitro models demonstrated that amniotic stem cells, in combination with amniocytes, can spontaneously repair small defects; because of the heterogenicity of the data, it is too early to draw a thoughtful conclusion. Future therapies should focus on materials and methods for sealing fetal membranes that are biocompatible, absorbable, available, easy to apply, and easily adherent to the fetal membrane. MDPI 2023-07-04 /pmc/articles/PMC10377155/ /pubmed/37509539 http://dx.doi.org/10.3390/biomedicines11071900 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Systematic Review
Danciu, Bianca Mihaela
Oţelea, Marina Ruxandra
Marincaş, Marian Augustin
Niţescu, Maria
Simionescu, Anca Angela
Is Spontaneous Preterm Prelabor of Membrane Rupture Irreversible? A Review of Potentially Curative Approaches
title Is Spontaneous Preterm Prelabor of Membrane Rupture Irreversible? A Review of Potentially Curative Approaches
title_full Is Spontaneous Preterm Prelabor of Membrane Rupture Irreversible? A Review of Potentially Curative Approaches
title_fullStr Is Spontaneous Preterm Prelabor of Membrane Rupture Irreversible? A Review of Potentially Curative Approaches
title_full_unstemmed Is Spontaneous Preterm Prelabor of Membrane Rupture Irreversible? A Review of Potentially Curative Approaches
title_short Is Spontaneous Preterm Prelabor of Membrane Rupture Irreversible? A Review of Potentially Curative Approaches
title_sort is spontaneous preterm prelabor of membrane rupture irreversible? a review of potentially curative approaches
topic Systematic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10377155/
https://www.ncbi.nlm.nih.gov/pubmed/37509539
http://dx.doi.org/10.3390/biomedicines11071900
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