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NETs-Induced Thrombosis Impacts on Cardiovascular and Chronic Kidney Disease

Arterial and venous thrombosis constitute a major source of morbidity and mortality worldwide. Association between thrombotic complications and cardiovascular and other chronic inflammatory diseases are well described. Inflammation and subsequent initiation of thrombotic events, termed immunothrombo...

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Autores principales: Thakur, Manovriti, Junho, Carolina Victoria Cruz, Bernhard, Sarah Maike, Schindewolf, Marc, Noels, Heidi, Döring, Yvonne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10377271/
https://www.ncbi.nlm.nih.gov/pubmed/37053273
http://dx.doi.org/10.1161/CIRCRESAHA.123.321750
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author Thakur, Manovriti
Junho, Carolina Victoria Cruz
Bernhard, Sarah Maike
Schindewolf, Marc
Noels, Heidi
Döring, Yvonne
author_facet Thakur, Manovriti
Junho, Carolina Victoria Cruz
Bernhard, Sarah Maike
Schindewolf, Marc
Noels, Heidi
Döring, Yvonne
author_sort Thakur, Manovriti
collection PubMed
description Arterial and venous thrombosis constitute a major source of morbidity and mortality worldwide. Association between thrombotic complications and cardiovascular and other chronic inflammatory diseases are well described. Inflammation and subsequent initiation of thrombotic events, termed immunothrombosis, also receive growing attention but are still incompletely understood. Nevertheless, the clinical relevance of aberrant immunothrombosis, referred to as thromboinflammation, is evident by an increased risk of thrombosis and cardiovascular events in patients with inflammatory or infectious diseases. Proinflammatory mediators released from platelets, complement activation, and the formation of NETs (neutrophil extracellular traps) initiate and foster immunothrombosis. In this review, we highlight and discuss prominent and emerging interrelationships and functions between NETs and other mediators in immunothrombosis in cardiovascular disease. Also, with patients with chronic kidney disease suffering from increased cardiovascular and thrombotic risk, we summarize current knowledge on neutrophil phenotype, function, and NET formation in chronic kidney disease. In addition, we elaborate on therapeutic targeting of NETs-induced immunothrombosis. A better understanding of the functional relevance of antithrombotic mediators which do not increase bleeding risk may provide opportunities for successful therapeutic interventions to reduce thrombotic risk beyond current treatment options.
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spelling pubmed-103772712023-07-29 NETs-Induced Thrombosis Impacts on Cardiovascular and Chronic Kidney Disease Thakur, Manovriti Junho, Carolina Victoria Cruz Bernhard, Sarah Maike Schindewolf, Marc Noels, Heidi Döring, Yvonne Circ Res Compendium On Increased Risk of Cardiovascular Complications in Chronic Kidney Disease Arterial and venous thrombosis constitute a major source of morbidity and mortality worldwide. Association between thrombotic complications and cardiovascular and other chronic inflammatory diseases are well described. Inflammation and subsequent initiation of thrombotic events, termed immunothrombosis, also receive growing attention but are still incompletely understood. Nevertheless, the clinical relevance of aberrant immunothrombosis, referred to as thromboinflammation, is evident by an increased risk of thrombosis and cardiovascular events in patients with inflammatory or infectious diseases. Proinflammatory mediators released from platelets, complement activation, and the formation of NETs (neutrophil extracellular traps) initiate and foster immunothrombosis. In this review, we highlight and discuss prominent and emerging interrelationships and functions between NETs and other mediators in immunothrombosis in cardiovascular disease. Also, with patients with chronic kidney disease suffering from increased cardiovascular and thrombotic risk, we summarize current knowledge on neutrophil phenotype, function, and NET formation in chronic kidney disease. In addition, we elaborate on therapeutic targeting of NETs-induced immunothrombosis. A better understanding of the functional relevance of antithrombotic mediators which do not increase bleeding risk may provide opportunities for successful therapeutic interventions to reduce thrombotic risk beyond current treatment options. Lippincott Williams & Wilkins 2023-04-14 2023-04-14 /pmc/articles/PMC10377271/ /pubmed/37053273 http://dx.doi.org/10.1161/CIRCRESAHA.123.321750 Text en © 2023 The Authors. https://creativecommons.org/licenses/by-nc-nd/4.0/Circulation Research is published on behalf of the American Heart Association, Inc., by Wolters Kluwer Health, Inc. This is an open access article under the terms of the Creative Commons Attribution Non-Commercial-NoDerivs (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use, distribution, and reproduction in any medium, provided that the original work is properly cited, the use is noncommercial, and no modifications or adaptations are made.
spellingShingle Compendium On Increased Risk of Cardiovascular Complications in Chronic Kidney Disease
Thakur, Manovriti
Junho, Carolina Victoria Cruz
Bernhard, Sarah Maike
Schindewolf, Marc
Noels, Heidi
Döring, Yvonne
NETs-Induced Thrombosis Impacts on Cardiovascular and Chronic Kidney Disease
title NETs-Induced Thrombosis Impacts on Cardiovascular and Chronic Kidney Disease
title_full NETs-Induced Thrombosis Impacts on Cardiovascular and Chronic Kidney Disease
title_fullStr NETs-Induced Thrombosis Impacts on Cardiovascular and Chronic Kidney Disease
title_full_unstemmed NETs-Induced Thrombosis Impacts on Cardiovascular and Chronic Kidney Disease
title_short NETs-Induced Thrombosis Impacts on Cardiovascular and Chronic Kidney Disease
title_sort nets-induced thrombosis impacts on cardiovascular and chronic kidney disease
topic Compendium On Increased Risk of Cardiovascular Complications in Chronic Kidney Disease
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10377271/
https://www.ncbi.nlm.nih.gov/pubmed/37053273
http://dx.doi.org/10.1161/CIRCRESAHA.123.321750
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