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Prognostic Significance of PD-L1 Expression in Gastric Cancer Patients with Peritoneal Metastasis
Background: Recently, many studies have explored the relationship between the expression of programmed death ligand 1 (PD-L1) and prognosis in gastric cancer, but there is still controversy. Additionally, few studies have specifically investigated the expression of PD-L1 in patients with peritoneal...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10377298/ https://www.ncbi.nlm.nih.gov/pubmed/37509642 http://dx.doi.org/10.3390/biomedicines11072003 |
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author | Chen, Xiao-Jiang Wei, Cheng-Zhi Lin, Jun Zhang, Ruo-Peng Chen, Guo-Ming Li, Yuan-Fang Nie, Run-Cong Chen, Yong-Ming |
author_facet | Chen, Xiao-Jiang Wei, Cheng-Zhi Lin, Jun Zhang, Ruo-Peng Chen, Guo-Ming Li, Yuan-Fang Nie, Run-Cong Chen, Yong-Ming |
author_sort | Chen, Xiao-Jiang |
collection | PubMed |
description | Background: Recently, many studies have explored the relationship between the expression of programmed death ligand 1 (PD-L1) and prognosis in gastric cancer, but there is still controversy. Additionally, few studies have specifically investigated the expression of PD-L1 in patients with peritoneal metastasis. Methods: Immunohistochemistry was used to analyze the expression of PD-L1 in gastric cancer patients with peritoneal metastasis. The combined positive score (CPS) was calculated to evaluate the expression of PD-L1, and the clinicopathological data were analyzed to explore prognostic significance. Results: In total, 147 gastric cancer patients with peritoneal metastasis were enrolled. The negative PD-L1 expression was defined as a CPS < 1, and high PD-L1 expression was defined as a CPS ≥ 10. PD-L1 expression with CPS ≥ 1 and CPS-negative was detected in 67 (45.58%) and 80 (54.42%) patients, respectively. High PD-L1 expression at PD-L1 CPS ≥ 10 was detected in 21(14.29%) patients. The median overall survival (OS) was 18.53 months in the CPS < 10 group and 27.00 months in the CPS ≥ 10 group; the OS difference between the two groups was significant (p = 0.015). Multivariate analysis demonstrated that a poor Eastern Cooperative Oncology Group performance score (ECOG PS) (p = 0.002) and severe peritoneal metastasis (p = 0.033) were significantly associated with poor survival, while palliative chemotherapy (p = 0.002) and high PD-L1 expression (p = 0.008) were independent and significantly favorable prognostic factors. Conclusions: Our study demonstrated that PD-L1 expression was widely presented in gastric cancer patients with peritoneal metastasis, while a CPS no less than 10 predicted better prognosis. |
format | Online Article Text |
id | pubmed-10377298 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-103772982023-07-29 Prognostic Significance of PD-L1 Expression in Gastric Cancer Patients with Peritoneal Metastasis Chen, Xiao-Jiang Wei, Cheng-Zhi Lin, Jun Zhang, Ruo-Peng Chen, Guo-Ming Li, Yuan-Fang Nie, Run-Cong Chen, Yong-Ming Biomedicines Article Background: Recently, many studies have explored the relationship between the expression of programmed death ligand 1 (PD-L1) and prognosis in gastric cancer, but there is still controversy. Additionally, few studies have specifically investigated the expression of PD-L1 in patients with peritoneal metastasis. Methods: Immunohistochemistry was used to analyze the expression of PD-L1 in gastric cancer patients with peritoneal metastasis. The combined positive score (CPS) was calculated to evaluate the expression of PD-L1, and the clinicopathological data were analyzed to explore prognostic significance. Results: In total, 147 gastric cancer patients with peritoneal metastasis were enrolled. The negative PD-L1 expression was defined as a CPS < 1, and high PD-L1 expression was defined as a CPS ≥ 10. PD-L1 expression with CPS ≥ 1 and CPS-negative was detected in 67 (45.58%) and 80 (54.42%) patients, respectively. High PD-L1 expression at PD-L1 CPS ≥ 10 was detected in 21(14.29%) patients. The median overall survival (OS) was 18.53 months in the CPS < 10 group and 27.00 months in the CPS ≥ 10 group; the OS difference between the two groups was significant (p = 0.015). Multivariate analysis demonstrated that a poor Eastern Cooperative Oncology Group performance score (ECOG PS) (p = 0.002) and severe peritoneal metastasis (p = 0.033) were significantly associated with poor survival, while palliative chemotherapy (p = 0.002) and high PD-L1 expression (p = 0.008) were independent and significantly favorable prognostic factors. Conclusions: Our study demonstrated that PD-L1 expression was widely presented in gastric cancer patients with peritoneal metastasis, while a CPS no less than 10 predicted better prognosis. MDPI 2023-07-15 /pmc/articles/PMC10377298/ /pubmed/37509642 http://dx.doi.org/10.3390/biomedicines11072003 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Chen, Xiao-Jiang Wei, Cheng-Zhi Lin, Jun Zhang, Ruo-Peng Chen, Guo-Ming Li, Yuan-Fang Nie, Run-Cong Chen, Yong-Ming Prognostic Significance of PD-L1 Expression in Gastric Cancer Patients with Peritoneal Metastasis |
title | Prognostic Significance of PD-L1 Expression in Gastric Cancer Patients with Peritoneal Metastasis |
title_full | Prognostic Significance of PD-L1 Expression in Gastric Cancer Patients with Peritoneal Metastasis |
title_fullStr | Prognostic Significance of PD-L1 Expression in Gastric Cancer Patients with Peritoneal Metastasis |
title_full_unstemmed | Prognostic Significance of PD-L1 Expression in Gastric Cancer Patients with Peritoneal Metastasis |
title_short | Prognostic Significance of PD-L1 Expression in Gastric Cancer Patients with Peritoneal Metastasis |
title_sort | prognostic significance of pd-l1 expression in gastric cancer patients with peritoneal metastasis |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10377298/ https://www.ncbi.nlm.nih.gov/pubmed/37509642 http://dx.doi.org/10.3390/biomedicines11072003 |
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