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The Outstanding Chemodiversity of Marine-Derived Talaromyces

Fungi in the genus Talaromyces occur in every environment in both terrestrial and marine contexts, where they have been quite frequently found in association with plants and animals. The relationships of symbiotic fungi with their hosts are often mediated by bioactive secondary metabolites, and Tala...

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Detalles Bibliográficos
Autores principales: Nicoletti, Rosario, Bellavita, Rosa, Falanga, Annarita
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10377321/
https://www.ncbi.nlm.nih.gov/pubmed/37509057
http://dx.doi.org/10.3390/biom13071021
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author Nicoletti, Rosario
Bellavita, Rosa
Falanga, Annarita
author_facet Nicoletti, Rosario
Bellavita, Rosa
Falanga, Annarita
author_sort Nicoletti, Rosario
collection PubMed
description Fungi in the genus Talaromyces occur in every environment in both terrestrial and marine contexts, where they have been quite frequently found in association with plants and animals. The relationships of symbiotic fungi with their hosts are often mediated by bioactive secondary metabolites, and Talaromyces species represent a prolific source of these compounds. This review highlights the biosynthetic potential of marine-derived Talaromyces strains, using accounts from the literature published since 2016. Over 500 secondary metabolites were extracted from axenic cultures of these isolates and about 45% of them were identified as new products, representing a various assortment of chemical classes such as alkaloids, meroterpenoids, isocoumarins, anthraquinones, xanthones, phenalenones, benzofurans, azaphilones, and other polyketides. This impressive chemodiversity and the broad range of biological properties that have been disclosed in preliminary assays qualify these fungi as a valuable source of products to be exploited for manifold biotechnological applications.
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spelling pubmed-103773212023-07-29 The Outstanding Chemodiversity of Marine-Derived Talaromyces Nicoletti, Rosario Bellavita, Rosa Falanga, Annarita Biomolecules Review Fungi in the genus Talaromyces occur in every environment in both terrestrial and marine contexts, where they have been quite frequently found in association with plants and animals. The relationships of symbiotic fungi with their hosts are often mediated by bioactive secondary metabolites, and Talaromyces species represent a prolific source of these compounds. This review highlights the biosynthetic potential of marine-derived Talaromyces strains, using accounts from the literature published since 2016. Over 500 secondary metabolites were extracted from axenic cultures of these isolates and about 45% of them were identified as new products, representing a various assortment of chemical classes such as alkaloids, meroterpenoids, isocoumarins, anthraquinones, xanthones, phenalenones, benzofurans, azaphilones, and other polyketides. This impressive chemodiversity and the broad range of biological properties that have been disclosed in preliminary assays qualify these fungi as a valuable source of products to be exploited for manifold biotechnological applications. MDPI 2023-06-21 /pmc/articles/PMC10377321/ /pubmed/37509057 http://dx.doi.org/10.3390/biom13071021 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Nicoletti, Rosario
Bellavita, Rosa
Falanga, Annarita
The Outstanding Chemodiversity of Marine-Derived Talaromyces
title The Outstanding Chemodiversity of Marine-Derived Talaromyces
title_full The Outstanding Chemodiversity of Marine-Derived Talaromyces
title_fullStr The Outstanding Chemodiversity of Marine-Derived Talaromyces
title_full_unstemmed The Outstanding Chemodiversity of Marine-Derived Talaromyces
title_short The Outstanding Chemodiversity of Marine-Derived Talaromyces
title_sort outstanding chemodiversity of marine-derived talaromyces
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10377321/
https://www.ncbi.nlm.nih.gov/pubmed/37509057
http://dx.doi.org/10.3390/biom13071021
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