Cargando…
The Outstanding Chemodiversity of Marine-Derived Talaromyces
Fungi in the genus Talaromyces occur in every environment in both terrestrial and marine contexts, where they have been quite frequently found in association with plants and animals. The relationships of symbiotic fungi with their hosts are often mediated by bioactive secondary metabolites, and Tala...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10377321/ https://www.ncbi.nlm.nih.gov/pubmed/37509057 http://dx.doi.org/10.3390/biom13071021 |
_version_ | 1785079489042055168 |
---|---|
author | Nicoletti, Rosario Bellavita, Rosa Falanga, Annarita |
author_facet | Nicoletti, Rosario Bellavita, Rosa Falanga, Annarita |
author_sort | Nicoletti, Rosario |
collection | PubMed |
description | Fungi in the genus Talaromyces occur in every environment in both terrestrial and marine contexts, where they have been quite frequently found in association with plants and animals. The relationships of symbiotic fungi with their hosts are often mediated by bioactive secondary metabolites, and Talaromyces species represent a prolific source of these compounds. This review highlights the biosynthetic potential of marine-derived Talaromyces strains, using accounts from the literature published since 2016. Over 500 secondary metabolites were extracted from axenic cultures of these isolates and about 45% of them were identified as new products, representing a various assortment of chemical classes such as alkaloids, meroterpenoids, isocoumarins, anthraquinones, xanthones, phenalenones, benzofurans, azaphilones, and other polyketides. This impressive chemodiversity and the broad range of biological properties that have been disclosed in preliminary assays qualify these fungi as a valuable source of products to be exploited for manifold biotechnological applications. |
format | Online Article Text |
id | pubmed-10377321 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-103773212023-07-29 The Outstanding Chemodiversity of Marine-Derived Talaromyces Nicoletti, Rosario Bellavita, Rosa Falanga, Annarita Biomolecules Review Fungi in the genus Talaromyces occur in every environment in both terrestrial and marine contexts, where they have been quite frequently found in association with plants and animals. The relationships of symbiotic fungi with their hosts are often mediated by bioactive secondary metabolites, and Talaromyces species represent a prolific source of these compounds. This review highlights the biosynthetic potential of marine-derived Talaromyces strains, using accounts from the literature published since 2016. Over 500 secondary metabolites were extracted from axenic cultures of these isolates and about 45% of them were identified as new products, representing a various assortment of chemical classes such as alkaloids, meroterpenoids, isocoumarins, anthraquinones, xanthones, phenalenones, benzofurans, azaphilones, and other polyketides. This impressive chemodiversity and the broad range of biological properties that have been disclosed in preliminary assays qualify these fungi as a valuable source of products to be exploited for manifold biotechnological applications. MDPI 2023-06-21 /pmc/articles/PMC10377321/ /pubmed/37509057 http://dx.doi.org/10.3390/biom13071021 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Nicoletti, Rosario Bellavita, Rosa Falanga, Annarita The Outstanding Chemodiversity of Marine-Derived Talaromyces |
title | The Outstanding Chemodiversity of Marine-Derived Talaromyces |
title_full | The Outstanding Chemodiversity of Marine-Derived Talaromyces |
title_fullStr | The Outstanding Chemodiversity of Marine-Derived Talaromyces |
title_full_unstemmed | The Outstanding Chemodiversity of Marine-Derived Talaromyces |
title_short | The Outstanding Chemodiversity of Marine-Derived Talaromyces |
title_sort | outstanding chemodiversity of marine-derived talaromyces |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10377321/ https://www.ncbi.nlm.nih.gov/pubmed/37509057 http://dx.doi.org/10.3390/biom13071021 |
work_keys_str_mv | AT nicolettirosario theoutstandingchemodiversityofmarinederivedtalaromyces AT bellavitarosa theoutstandingchemodiversityofmarinederivedtalaromyces AT falangaannarita theoutstandingchemodiversityofmarinederivedtalaromyces AT nicolettirosario outstandingchemodiversityofmarinederivedtalaromyces AT bellavitarosa outstandingchemodiversityofmarinederivedtalaromyces AT falangaannarita outstandingchemodiversityofmarinederivedtalaromyces |