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Serotonergic Modulation of Neurovascular Transmission: A Focus on Prejunctional 5-HT Receptors/Mechanisms

5-Hydroxytryptamine (5-HT), or serotonin, plays a crucial role as a neuromodulator and/or neurotransmitter of several nervous system functions. Its actions are complex, and depend on multiple factors, including the type of effector or receptor activated. Briefly, 5-HT can activate: (i) metabotropic...

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Autores principales: González-Hernández, Abimael, Marichal-Cancino, Bruno A., MaassenVanDenBrink, Antoinette, Villalón, Carlos M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10377335/
https://www.ncbi.nlm.nih.gov/pubmed/37509503
http://dx.doi.org/10.3390/biomedicines11071864
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author González-Hernández, Abimael
Marichal-Cancino, Bruno A.
MaassenVanDenBrink, Antoinette
Villalón, Carlos M.
author_facet González-Hernández, Abimael
Marichal-Cancino, Bruno A.
MaassenVanDenBrink, Antoinette
Villalón, Carlos M.
author_sort González-Hernández, Abimael
collection PubMed
description 5-Hydroxytryptamine (5-HT), or serotonin, plays a crucial role as a neuromodulator and/or neurotransmitter of several nervous system functions. Its actions are complex, and depend on multiple factors, including the type of effector or receptor activated. Briefly, 5-HT can activate: (i) metabotropic (G-protein-coupled) receptors to promote inhibition (5-HT(1), 5-HT(5)) or activation (5-HT(4), 5-HT(6), 5-HT(7)) of adenylate cyclase, as well as activation (5-HT(2)) of phospholipase C; and (ii) ionotropic receptor (5-HT(3)), a ligand-gated Na(+)/K(+) channel. Regarding blood pressure regulation (and beyond the intricacy of central 5-HT effects), this monoamine also exerts direct postjunctional (on vascular smooth muscle and endothelium) or indirect prejunctional (on autonomic and sensory perivascular nerves) effects. At the prejunctional level, 5-HT can facilitate or preclude the release of autonomic (e.g., noradrenaline and acetylcholine) or sensory (e.g., calcitonin gene-related peptide) neurotransmitters facilitating hypertensive or hypotensive effects. Hence, we cannot formulate a specific impact of 5-HT on blood pressure level, since an increase or decrease in neurotransmitter release would be favoured, depending on the type of prejunctional receptor involved. This review summarizes and discusses the current knowledge on the prejunctional mechanisms involved in blood pressure regulation by 5-HT and its impact on some vascular-related diseases.
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spelling pubmed-103773352023-07-29 Serotonergic Modulation of Neurovascular Transmission: A Focus on Prejunctional 5-HT Receptors/Mechanisms González-Hernández, Abimael Marichal-Cancino, Bruno A. MaassenVanDenBrink, Antoinette Villalón, Carlos M. Biomedicines Review 5-Hydroxytryptamine (5-HT), or serotonin, plays a crucial role as a neuromodulator and/or neurotransmitter of several nervous system functions. Its actions are complex, and depend on multiple factors, including the type of effector or receptor activated. Briefly, 5-HT can activate: (i) metabotropic (G-protein-coupled) receptors to promote inhibition (5-HT(1), 5-HT(5)) or activation (5-HT(4), 5-HT(6), 5-HT(7)) of adenylate cyclase, as well as activation (5-HT(2)) of phospholipase C; and (ii) ionotropic receptor (5-HT(3)), a ligand-gated Na(+)/K(+) channel. Regarding blood pressure regulation (and beyond the intricacy of central 5-HT effects), this monoamine also exerts direct postjunctional (on vascular smooth muscle and endothelium) or indirect prejunctional (on autonomic and sensory perivascular nerves) effects. At the prejunctional level, 5-HT can facilitate or preclude the release of autonomic (e.g., noradrenaline and acetylcholine) or sensory (e.g., calcitonin gene-related peptide) neurotransmitters facilitating hypertensive or hypotensive effects. Hence, we cannot formulate a specific impact of 5-HT on blood pressure level, since an increase or decrease in neurotransmitter release would be favoured, depending on the type of prejunctional receptor involved. This review summarizes and discusses the current knowledge on the prejunctional mechanisms involved in blood pressure regulation by 5-HT and its impact on some vascular-related diseases. MDPI 2023-06-29 /pmc/articles/PMC10377335/ /pubmed/37509503 http://dx.doi.org/10.3390/biomedicines11071864 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
González-Hernández, Abimael
Marichal-Cancino, Bruno A.
MaassenVanDenBrink, Antoinette
Villalón, Carlos M.
Serotonergic Modulation of Neurovascular Transmission: A Focus on Prejunctional 5-HT Receptors/Mechanisms
title Serotonergic Modulation of Neurovascular Transmission: A Focus on Prejunctional 5-HT Receptors/Mechanisms
title_full Serotonergic Modulation of Neurovascular Transmission: A Focus on Prejunctional 5-HT Receptors/Mechanisms
title_fullStr Serotonergic Modulation of Neurovascular Transmission: A Focus on Prejunctional 5-HT Receptors/Mechanisms
title_full_unstemmed Serotonergic Modulation of Neurovascular Transmission: A Focus on Prejunctional 5-HT Receptors/Mechanisms
title_short Serotonergic Modulation of Neurovascular Transmission: A Focus on Prejunctional 5-HT Receptors/Mechanisms
title_sort serotonergic modulation of neurovascular transmission: a focus on prejunctional 5-ht receptors/mechanisms
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10377335/
https://www.ncbi.nlm.nih.gov/pubmed/37509503
http://dx.doi.org/10.3390/biomedicines11071864
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