Cargando…

CASZ1: Current Implications in Cardiovascular Diseases and Cancers

Castor zinc finger 1 (CASZ1) is a C2H2 zinc finger family protein that has two splicing variants, CASZ1a and CASZ1b. It is involved in multiple physiological processes, such as tissue differentiation and aldosterone antagonism. Genetic and epigenetic alternations of CASZ1 have been characterized in...

Descripción completa

Detalles Bibliográficos
Autores principales: Jian, Heng, Poetsch, Ansgar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10377389/
https://www.ncbi.nlm.nih.gov/pubmed/37509718
http://dx.doi.org/10.3390/biomedicines11072079
_version_ 1785079505356849152
author Jian, Heng
Poetsch, Ansgar
author_facet Jian, Heng
Poetsch, Ansgar
author_sort Jian, Heng
collection PubMed
description Castor zinc finger 1 (CASZ1) is a C2H2 zinc finger family protein that has two splicing variants, CASZ1a and CASZ1b. It is involved in multiple physiological processes, such as tissue differentiation and aldosterone antagonism. Genetic and epigenetic alternations of CASZ1 have been characterized in multiple cardiovascular disorders, such as congenital heart diseases, chronic venous diseases, and hypertension. However, little is known about how CASZ1 mechanically participates in the pathogenesis of these diseases. Over the past decades, at first glance, paradoxical influences on cell behaviors and progressions of different cancer types have been discovered for CASZ1, which may be explained by a “double-agent” role for CASZ1. In this review, we discuss the physiological function of CASZ1, and focus on the association of CASZ1 aberrations with the pathogenesis of cardiovascular diseases and cancers.
format Online
Article
Text
id pubmed-10377389
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-103773892023-07-29 CASZ1: Current Implications in Cardiovascular Diseases and Cancers Jian, Heng Poetsch, Ansgar Biomedicines Review Castor zinc finger 1 (CASZ1) is a C2H2 zinc finger family protein that has two splicing variants, CASZ1a and CASZ1b. It is involved in multiple physiological processes, such as tissue differentiation and aldosterone antagonism. Genetic and epigenetic alternations of CASZ1 have been characterized in multiple cardiovascular disorders, such as congenital heart diseases, chronic venous diseases, and hypertension. However, little is known about how CASZ1 mechanically participates in the pathogenesis of these diseases. Over the past decades, at first glance, paradoxical influences on cell behaviors and progressions of different cancer types have been discovered for CASZ1, which may be explained by a “double-agent” role for CASZ1. In this review, we discuss the physiological function of CASZ1, and focus on the association of CASZ1 aberrations with the pathogenesis of cardiovascular diseases and cancers. MDPI 2023-07-24 /pmc/articles/PMC10377389/ /pubmed/37509718 http://dx.doi.org/10.3390/biomedicines11072079 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Jian, Heng
Poetsch, Ansgar
CASZ1: Current Implications in Cardiovascular Diseases and Cancers
title CASZ1: Current Implications in Cardiovascular Diseases and Cancers
title_full CASZ1: Current Implications in Cardiovascular Diseases and Cancers
title_fullStr CASZ1: Current Implications in Cardiovascular Diseases and Cancers
title_full_unstemmed CASZ1: Current Implications in Cardiovascular Diseases and Cancers
title_short CASZ1: Current Implications in Cardiovascular Diseases and Cancers
title_sort casz1: current implications in cardiovascular diseases and cancers
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10377389/
https://www.ncbi.nlm.nih.gov/pubmed/37509718
http://dx.doi.org/10.3390/biomedicines11072079
work_keys_str_mv AT jianheng casz1currentimplicationsincardiovasculardiseasesandcancers
AT poetschansgar casz1currentimplicationsincardiovasculardiseasesandcancers