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CASZ1: Current Implications in Cardiovascular Diseases and Cancers
Castor zinc finger 1 (CASZ1) is a C2H2 zinc finger family protein that has two splicing variants, CASZ1a and CASZ1b. It is involved in multiple physiological processes, such as tissue differentiation and aldosterone antagonism. Genetic and epigenetic alternations of CASZ1 have been characterized in...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10377389/ https://www.ncbi.nlm.nih.gov/pubmed/37509718 http://dx.doi.org/10.3390/biomedicines11072079 |
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author | Jian, Heng Poetsch, Ansgar |
author_facet | Jian, Heng Poetsch, Ansgar |
author_sort | Jian, Heng |
collection | PubMed |
description | Castor zinc finger 1 (CASZ1) is a C2H2 zinc finger family protein that has two splicing variants, CASZ1a and CASZ1b. It is involved in multiple physiological processes, such as tissue differentiation and aldosterone antagonism. Genetic and epigenetic alternations of CASZ1 have been characterized in multiple cardiovascular disorders, such as congenital heart diseases, chronic venous diseases, and hypertension. However, little is known about how CASZ1 mechanically participates in the pathogenesis of these diseases. Over the past decades, at first glance, paradoxical influences on cell behaviors and progressions of different cancer types have been discovered for CASZ1, which may be explained by a “double-agent” role for CASZ1. In this review, we discuss the physiological function of CASZ1, and focus on the association of CASZ1 aberrations with the pathogenesis of cardiovascular diseases and cancers. |
format | Online Article Text |
id | pubmed-10377389 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-103773892023-07-29 CASZ1: Current Implications in Cardiovascular Diseases and Cancers Jian, Heng Poetsch, Ansgar Biomedicines Review Castor zinc finger 1 (CASZ1) is a C2H2 zinc finger family protein that has two splicing variants, CASZ1a and CASZ1b. It is involved in multiple physiological processes, such as tissue differentiation and aldosterone antagonism. Genetic and epigenetic alternations of CASZ1 have been characterized in multiple cardiovascular disorders, such as congenital heart diseases, chronic venous diseases, and hypertension. However, little is known about how CASZ1 mechanically participates in the pathogenesis of these diseases. Over the past decades, at first glance, paradoxical influences on cell behaviors and progressions of different cancer types have been discovered for CASZ1, which may be explained by a “double-agent” role for CASZ1. In this review, we discuss the physiological function of CASZ1, and focus on the association of CASZ1 aberrations with the pathogenesis of cardiovascular diseases and cancers. MDPI 2023-07-24 /pmc/articles/PMC10377389/ /pubmed/37509718 http://dx.doi.org/10.3390/biomedicines11072079 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Jian, Heng Poetsch, Ansgar CASZ1: Current Implications in Cardiovascular Diseases and Cancers |
title | CASZ1: Current Implications in Cardiovascular Diseases and Cancers |
title_full | CASZ1: Current Implications in Cardiovascular Diseases and Cancers |
title_fullStr | CASZ1: Current Implications in Cardiovascular Diseases and Cancers |
title_full_unstemmed | CASZ1: Current Implications in Cardiovascular Diseases and Cancers |
title_short | CASZ1: Current Implications in Cardiovascular Diseases and Cancers |
title_sort | casz1: current implications in cardiovascular diseases and cancers |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10377389/ https://www.ncbi.nlm.nih.gov/pubmed/37509718 http://dx.doi.org/10.3390/biomedicines11072079 |
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