Single Mutations in Cytochrome P450 Oxidoreductase Can Alter the Specificity of Human Cytochrome P450 1A2-Mediated Caffeine Metabolism

A unique cytochrome P450 (CYP) oxidoreductase (CPR) sustains activities of human microsomal CYPs. Its function requires toggling between a closed conformation enabling electron transfers from NADPH to FAD and then FMN cofactors and open conformations forming complexes and transferring electrons to C...

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Detalles Bibliográficos
Autores principales: Esteves, Francisco, Almeida, Cristina M. M., Silva, Sofia, Saldanha, Inês, Urban, Philippe, Rueff, José, Pompon, Denis, Truan, Gilles, Kranendonk, Michel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10377444/
https://www.ncbi.nlm.nih.gov/pubmed/37509119
http://dx.doi.org/10.3390/biom13071083

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