Cargando…

The Impact of Metabolic Syndrome on Bone Mass in Men: Systematic Review and Meta-Analysis

Studies to date have yielded conflicting results on associations between components of metabolic syndrome (MetS) and bone mineral density (BMD), particularly in men. This current systematic review and meta-analysis addresses the existing gap in the literature and aims to evaluate bone mineral densit...

Descripción completa

Detalles Bibliográficos
Autores principales: Rył, Aleksandra, Szylińska, Aleksandra, Skonieczna-Żydecka, Karolina, Miazgowski, Tomasz, Rotter, Iwona
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10377465/
https://www.ncbi.nlm.nih.gov/pubmed/37509553
http://dx.doi.org/10.3390/biomedicines11071915
_version_ 1785079524551032832
author Rył, Aleksandra
Szylińska, Aleksandra
Skonieczna-Żydecka, Karolina
Miazgowski, Tomasz
Rotter, Iwona
author_facet Rył, Aleksandra
Szylińska, Aleksandra
Skonieczna-Żydecka, Karolina
Miazgowski, Tomasz
Rotter, Iwona
author_sort Rył, Aleksandra
collection PubMed
description Studies to date have yielded conflicting results on associations between components of metabolic syndrome (MetS) and bone mineral density (BMD), particularly in men. This current systematic review and meta-analysis addresses the existing gap in the literature and aims to evaluate bone mineral density (BMD) at the femoral neck (FN) and lumbar spine (LS) in men diagnosed with MetS. The two study authors independently searched PubMed, Cinahl, Embase, and Web of Science up to 8 February 2022 for studies in English. The inclusion criteria were (i) diagnosis of MetS according to the NCEP-ATP III 2001 criteria; (ii) adult male demographic; (iii) analyzable data on BMD in at least two sites using dual-energy X-ray absorptiometry (DXA), and (iv) original observational studies. Case reports and non-English articles were excluded. We analyzed the results of seven studies providing data on bone density in men with MetS. Results: Based on random effect weights, the mean BMD of the femoral neck and lumbar spine were 0.84 and 1.02, respectively. The mean lumbar spine T-score was −0.92. In meta-regression analysis, the variances in mean BMD in the lumbar spine and femoral neck could not be significantly explained by BMI (lumbar BMD: Q = 1.10, df = 1, p = 0.29; femoral neck BMD: Q = 0.91, df = 1, p = 0.34). Our meta-analysis suggests normal bone mass in adult males with MetS. Due to the high heterogeneity in the seven analyzed studies and the lack of control groups in these studies, further research is needed to fully elucidate the associations between MetS and its components and BMD in men.
format Online
Article
Text
id pubmed-10377465
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-103774652023-07-29 The Impact of Metabolic Syndrome on Bone Mass in Men: Systematic Review and Meta-Analysis Rył, Aleksandra Szylińska, Aleksandra Skonieczna-Żydecka, Karolina Miazgowski, Tomasz Rotter, Iwona Biomedicines Systematic Review Studies to date have yielded conflicting results on associations between components of metabolic syndrome (MetS) and bone mineral density (BMD), particularly in men. This current systematic review and meta-analysis addresses the existing gap in the literature and aims to evaluate bone mineral density (BMD) at the femoral neck (FN) and lumbar spine (LS) in men diagnosed with MetS. The two study authors independently searched PubMed, Cinahl, Embase, and Web of Science up to 8 February 2022 for studies in English. The inclusion criteria were (i) diagnosis of MetS according to the NCEP-ATP III 2001 criteria; (ii) adult male demographic; (iii) analyzable data on BMD in at least two sites using dual-energy X-ray absorptiometry (DXA), and (iv) original observational studies. Case reports and non-English articles were excluded. We analyzed the results of seven studies providing data on bone density in men with MetS. Results: Based on random effect weights, the mean BMD of the femoral neck and lumbar spine were 0.84 and 1.02, respectively. The mean lumbar spine T-score was −0.92. In meta-regression analysis, the variances in mean BMD in the lumbar spine and femoral neck could not be significantly explained by BMI (lumbar BMD: Q = 1.10, df = 1, p = 0.29; femoral neck BMD: Q = 0.91, df = 1, p = 0.34). Our meta-analysis suggests normal bone mass in adult males with MetS. Due to the high heterogeneity in the seven analyzed studies and the lack of control groups in these studies, further research is needed to fully elucidate the associations between MetS and its components and BMD in men. MDPI 2023-07-06 /pmc/articles/PMC10377465/ /pubmed/37509553 http://dx.doi.org/10.3390/biomedicines11071915 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Systematic Review
Rył, Aleksandra
Szylińska, Aleksandra
Skonieczna-Żydecka, Karolina
Miazgowski, Tomasz
Rotter, Iwona
The Impact of Metabolic Syndrome on Bone Mass in Men: Systematic Review and Meta-Analysis
title The Impact of Metabolic Syndrome on Bone Mass in Men: Systematic Review and Meta-Analysis
title_full The Impact of Metabolic Syndrome on Bone Mass in Men: Systematic Review and Meta-Analysis
title_fullStr The Impact of Metabolic Syndrome on Bone Mass in Men: Systematic Review and Meta-Analysis
title_full_unstemmed The Impact of Metabolic Syndrome on Bone Mass in Men: Systematic Review and Meta-Analysis
title_short The Impact of Metabolic Syndrome on Bone Mass in Men: Systematic Review and Meta-Analysis
title_sort impact of metabolic syndrome on bone mass in men: systematic review and meta-analysis
topic Systematic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10377465/
https://www.ncbi.nlm.nih.gov/pubmed/37509553
http://dx.doi.org/10.3390/biomedicines11071915
work_keys_str_mv AT ryłaleksandra theimpactofmetabolicsyndromeonbonemassinmensystematicreviewandmetaanalysis
AT szylinskaaleksandra theimpactofmetabolicsyndromeonbonemassinmensystematicreviewandmetaanalysis
AT skoniecznazydeckakarolina theimpactofmetabolicsyndromeonbonemassinmensystematicreviewandmetaanalysis
AT miazgowskitomasz theimpactofmetabolicsyndromeonbonemassinmensystematicreviewandmetaanalysis
AT rotteriwona theimpactofmetabolicsyndromeonbonemassinmensystematicreviewandmetaanalysis
AT ryłaleksandra impactofmetabolicsyndromeonbonemassinmensystematicreviewandmetaanalysis
AT szylinskaaleksandra impactofmetabolicsyndromeonbonemassinmensystematicreviewandmetaanalysis
AT skoniecznazydeckakarolina impactofmetabolicsyndromeonbonemassinmensystematicreviewandmetaanalysis
AT miazgowskitomasz impactofmetabolicsyndromeonbonemassinmensystematicreviewandmetaanalysis
AT rotteriwona impactofmetabolicsyndromeonbonemassinmensystematicreviewandmetaanalysis