Cargando…

Application of MR Imaging Characteristics in the Differentiation of Renal Changes Between Patients with Stage III Type 2 Diabetic Kidney Disease and Healthy People

OBJECTIVE: To explore the value of 1.5T magnetic resonance (MR) fat saturation-T2-weighted imaging (FS-T2WI) and apparent diffusion coefficient (ADC) imaging texture features in distinguishing the renal changes of patients with stage III type 2 diabetic kidney disease (DKD) from healthy people. METH...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhang, Hao, Yu, Baoting, Yang, Hongsheng, Ying, Hongfei, Qu, Xiaolong, Zhu, Lilan, Wang, Cong, Ding, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10377559/
https://www.ncbi.nlm.nih.gov/pubmed/37521748
http://dx.doi.org/10.2147/DMSO.S413688
_version_ 1785079547746582528
author Zhang, Hao
Yu, Baoting
Yang, Hongsheng
Ying, Hongfei
Qu, Xiaolong
Zhu, Lilan
Wang, Cong
Ding, Jun
author_facet Zhang, Hao
Yu, Baoting
Yang, Hongsheng
Ying, Hongfei
Qu, Xiaolong
Zhu, Lilan
Wang, Cong
Ding, Jun
author_sort Zhang, Hao
collection PubMed
description OBJECTIVE: To explore the value of 1.5T magnetic resonance (MR) fat saturation-T2-weighted imaging (FS-T2WI) and apparent diffusion coefficient (ADC) imaging texture features in distinguishing the renal changes of patients with stage III type 2 diabetic kidney disease (DKD) from healthy people. METHODS: This study collected 55 patients with stage III DKD (39 males and 16 females) and 33 healthy controls (13 males and 20 females) from December 2021 to June 2022 in the China-Japan Union Hospital of Jilin University. All subjects were randomly divided in a ratio of 6:4 to extract and screen the FS-T2WI and ADC texture features of the right kidney of the subjects. The area under the curve (AUC) was used to assess the diagnostic accuracy of each model. RESULTS: There were significant differences between urea, creatinine and sex (p<0.05) of the two groups in the training and test set, and no significant difference in age and body mass index (BMI). We extracted 1409 imaging features from the original ADC sequence and selected them by wavelet and Laplace-Gaussian filter and LASSO algorithm, and using the same methods of FS-T2WI. Finally, FS-T2WI and ADC models were selected to construct the united model, including 3 first-order features and 8 texture features. The AUC values of the training set of FS-T2WI, ADC, FS-T2WI+ADC combined logistic regression model were 0.96, 0.91, 0.98; the AUC values of the test set were 0.91, 0.89 and 0.93, and the specificity and accuracy values of the united model were 0.90 and 0.89, respectively. CONCLUSION: FS-T2WI and ADC imaging features based on 1.5 T MR had diagnostic value in the early diagnosis of DKD stage III, and the combined model of FS-T2WI and ADC had high diagnostic efficiency.
format Online
Article
Text
id pubmed-10377559
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Dove
record_format MEDLINE/PubMed
spelling pubmed-103775592023-07-29 Application of MR Imaging Characteristics in the Differentiation of Renal Changes Between Patients with Stage III Type 2 Diabetic Kidney Disease and Healthy People Zhang, Hao Yu, Baoting Yang, Hongsheng Ying, Hongfei Qu, Xiaolong Zhu, Lilan Wang, Cong Ding, Jun Diabetes Metab Syndr Obes Original Research OBJECTIVE: To explore the value of 1.5T magnetic resonance (MR) fat saturation-T2-weighted imaging (FS-T2WI) and apparent diffusion coefficient (ADC) imaging texture features in distinguishing the renal changes of patients with stage III type 2 diabetic kidney disease (DKD) from healthy people. METHODS: This study collected 55 patients with stage III DKD (39 males and 16 females) and 33 healthy controls (13 males and 20 females) from December 2021 to June 2022 in the China-Japan Union Hospital of Jilin University. All subjects were randomly divided in a ratio of 6:4 to extract and screen the FS-T2WI and ADC texture features of the right kidney of the subjects. The area under the curve (AUC) was used to assess the diagnostic accuracy of each model. RESULTS: There were significant differences between urea, creatinine and sex (p<0.05) of the two groups in the training and test set, and no significant difference in age and body mass index (BMI). We extracted 1409 imaging features from the original ADC sequence and selected them by wavelet and Laplace-Gaussian filter and LASSO algorithm, and using the same methods of FS-T2WI. Finally, FS-T2WI and ADC models were selected to construct the united model, including 3 first-order features and 8 texture features. The AUC values of the training set of FS-T2WI, ADC, FS-T2WI+ADC combined logistic regression model were 0.96, 0.91, 0.98; the AUC values of the test set were 0.91, 0.89 and 0.93, and the specificity and accuracy values of the united model were 0.90 and 0.89, respectively. CONCLUSION: FS-T2WI and ADC imaging features based on 1.5 T MR had diagnostic value in the early diagnosis of DKD stage III, and the combined model of FS-T2WI and ADC had high diagnostic efficiency. Dove 2023-07-24 /pmc/articles/PMC10377559/ /pubmed/37521748 http://dx.doi.org/10.2147/DMSO.S413688 Text en © 2023 Zhang et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Original Research
Zhang, Hao
Yu, Baoting
Yang, Hongsheng
Ying, Hongfei
Qu, Xiaolong
Zhu, Lilan
Wang, Cong
Ding, Jun
Application of MR Imaging Characteristics in the Differentiation of Renal Changes Between Patients with Stage III Type 2 Diabetic Kidney Disease and Healthy People
title Application of MR Imaging Characteristics in the Differentiation of Renal Changes Between Patients with Stage III Type 2 Diabetic Kidney Disease and Healthy People
title_full Application of MR Imaging Characteristics in the Differentiation of Renal Changes Between Patients with Stage III Type 2 Diabetic Kidney Disease and Healthy People
title_fullStr Application of MR Imaging Characteristics in the Differentiation of Renal Changes Between Patients with Stage III Type 2 Diabetic Kidney Disease and Healthy People
title_full_unstemmed Application of MR Imaging Characteristics in the Differentiation of Renal Changes Between Patients with Stage III Type 2 Diabetic Kidney Disease and Healthy People
title_short Application of MR Imaging Characteristics in the Differentiation of Renal Changes Between Patients with Stage III Type 2 Diabetic Kidney Disease and Healthy People
title_sort application of mr imaging characteristics in the differentiation of renal changes between patients with stage iii type 2 diabetic kidney disease and healthy people
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10377559/
https://www.ncbi.nlm.nih.gov/pubmed/37521748
http://dx.doi.org/10.2147/DMSO.S413688
work_keys_str_mv AT zhanghao applicationofmrimagingcharacteristicsinthedifferentiationofrenalchangesbetweenpatientswithstageiiitype2diabetickidneydiseaseandhealthypeople
AT yubaoting applicationofmrimagingcharacteristicsinthedifferentiationofrenalchangesbetweenpatientswithstageiiitype2diabetickidneydiseaseandhealthypeople
AT yanghongsheng applicationofmrimagingcharacteristicsinthedifferentiationofrenalchangesbetweenpatientswithstageiiitype2diabetickidneydiseaseandhealthypeople
AT yinghongfei applicationofmrimagingcharacteristicsinthedifferentiationofrenalchangesbetweenpatientswithstageiiitype2diabetickidneydiseaseandhealthypeople
AT quxiaolong applicationofmrimagingcharacteristicsinthedifferentiationofrenalchangesbetweenpatientswithstageiiitype2diabetickidneydiseaseandhealthypeople
AT zhulilan applicationofmrimagingcharacteristicsinthedifferentiationofrenalchangesbetweenpatientswithstageiiitype2diabetickidneydiseaseandhealthypeople
AT wangcong applicationofmrimagingcharacteristicsinthedifferentiationofrenalchangesbetweenpatientswithstageiiitype2diabetickidneydiseaseandhealthypeople
AT dingjun applicationofmrimagingcharacteristicsinthedifferentiationofrenalchangesbetweenpatientswithstageiiitype2diabetickidneydiseaseandhealthypeople