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The Impact of Ethnicity and Age on Distribution of Metastases in Patients with Upper Tract Urothelial Carcinoma: Analysis of SEER Data

Upper tract urothelial carcinoma (UTUC) constitutes a rare and aggressive entity accounting for 5% to 10% of all urothelial tumors. The importance of stratification and disparities according to ethnicity and age has never been tested in a sufficiently large sample of patients with metastatic UTUC (m...

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Autores principales: Tufano, Antonio, Perdonà, Sisto, Viscuso, Pietro, Frisenda, Marco, Canale, Vittorio, Rossi, Antonio, Del Prete, Paola, Passaro, Francesco, Calarco, Alessandro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10377577/
https://www.ncbi.nlm.nih.gov/pubmed/37509582
http://dx.doi.org/10.3390/biomedicines11071943
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author Tufano, Antonio
Perdonà, Sisto
Viscuso, Pietro
Frisenda, Marco
Canale, Vittorio
Rossi, Antonio
Del Prete, Paola
Passaro, Francesco
Calarco, Alessandro
author_facet Tufano, Antonio
Perdonà, Sisto
Viscuso, Pietro
Frisenda, Marco
Canale, Vittorio
Rossi, Antonio
Del Prete, Paola
Passaro, Francesco
Calarco, Alessandro
author_sort Tufano, Antonio
collection PubMed
description Upper tract urothelial carcinoma (UTUC) constitutes a rare and aggressive entity accounting for 5% to 10% of all urothelial tumors. The importance of stratification and disparities according to ethnicity and age has never been tested in a sufficiently large sample of patients with metastatic UTUC (mUTUC). We conducted this study to address this void, and we hypothesized that the distribution of metastases may vary according to age and ethnicity. Within the Surveillance, Epidemiology, and End Results (SEER) database (2004–2016), we identified 1115 patients with mUTUC. The chi-square and t-test tests were used to examine statistical significance in terms of proportions and mean differences. A total of 925 (83.0%) patients were Caucasians, while 190 (17.0%) were African Americans. Among both ethnicities, lungs were the most common metastatic site (39.1% vs. 48.9%). Brain metastases were infrequent among both ethnicities (1.2 vs. 2.6%; p = 0.13). The trends in the lung metastases decreased with age from 42.3% to 36.6% (p = 0.010) among Caucasians, whereas they increased among African Americans from 34.0% to 51.7% (p = 0.04). Overall, 32.8% of Caucasians and 40.5% of African Americans exhibited more than one metastatic site. Among Caucasians, increasing age was associated with lower rates of having multiple metastatic sites (from 34.3% to 30.2%) (p = 0.004). According to our multivariable analyses, younger age was associated with an increased risk of lung (OR: 1.29, 95% CI 1.04–1.71; p = 0.045) and bone metastases (OR: 1.34, 95% CI 1.07–1.79; p = 0.046). Racial differences exist in the distribution of mUTUC metastasis and vary according to age. Our findings may also be considered in the design of randomized trials.
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spelling pubmed-103775772023-07-29 The Impact of Ethnicity and Age on Distribution of Metastases in Patients with Upper Tract Urothelial Carcinoma: Analysis of SEER Data Tufano, Antonio Perdonà, Sisto Viscuso, Pietro Frisenda, Marco Canale, Vittorio Rossi, Antonio Del Prete, Paola Passaro, Francesco Calarco, Alessandro Biomedicines Article Upper tract urothelial carcinoma (UTUC) constitutes a rare and aggressive entity accounting for 5% to 10% of all urothelial tumors. The importance of stratification and disparities according to ethnicity and age has never been tested in a sufficiently large sample of patients with metastatic UTUC (mUTUC). We conducted this study to address this void, and we hypothesized that the distribution of metastases may vary according to age and ethnicity. Within the Surveillance, Epidemiology, and End Results (SEER) database (2004–2016), we identified 1115 patients with mUTUC. The chi-square and t-test tests were used to examine statistical significance in terms of proportions and mean differences. A total of 925 (83.0%) patients were Caucasians, while 190 (17.0%) were African Americans. Among both ethnicities, lungs were the most common metastatic site (39.1% vs. 48.9%). Brain metastases were infrequent among both ethnicities (1.2 vs. 2.6%; p = 0.13). The trends in the lung metastases decreased with age from 42.3% to 36.6% (p = 0.010) among Caucasians, whereas they increased among African Americans from 34.0% to 51.7% (p = 0.04). Overall, 32.8% of Caucasians and 40.5% of African Americans exhibited more than one metastatic site. Among Caucasians, increasing age was associated with lower rates of having multiple metastatic sites (from 34.3% to 30.2%) (p = 0.004). According to our multivariable analyses, younger age was associated with an increased risk of lung (OR: 1.29, 95% CI 1.04–1.71; p = 0.045) and bone metastases (OR: 1.34, 95% CI 1.07–1.79; p = 0.046). Racial differences exist in the distribution of mUTUC metastasis and vary according to age. Our findings may also be considered in the design of randomized trials. MDPI 2023-07-08 /pmc/articles/PMC10377577/ /pubmed/37509582 http://dx.doi.org/10.3390/biomedicines11071943 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Tufano, Antonio
Perdonà, Sisto
Viscuso, Pietro
Frisenda, Marco
Canale, Vittorio
Rossi, Antonio
Del Prete, Paola
Passaro, Francesco
Calarco, Alessandro
The Impact of Ethnicity and Age on Distribution of Metastases in Patients with Upper Tract Urothelial Carcinoma: Analysis of SEER Data
title The Impact of Ethnicity and Age on Distribution of Metastases in Patients with Upper Tract Urothelial Carcinoma: Analysis of SEER Data
title_full The Impact of Ethnicity and Age on Distribution of Metastases in Patients with Upper Tract Urothelial Carcinoma: Analysis of SEER Data
title_fullStr The Impact of Ethnicity and Age on Distribution of Metastases in Patients with Upper Tract Urothelial Carcinoma: Analysis of SEER Data
title_full_unstemmed The Impact of Ethnicity and Age on Distribution of Metastases in Patients with Upper Tract Urothelial Carcinoma: Analysis of SEER Data
title_short The Impact of Ethnicity and Age on Distribution of Metastases in Patients with Upper Tract Urothelial Carcinoma: Analysis of SEER Data
title_sort impact of ethnicity and age on distribution of metastases in patients with upper tract urothelial carcinoma: analysis of seer data
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10377577/
https://www.ncbi.nlm.nih.gov/pubmed/37509582
http://dx.doi.org/10.3390/biomedicines11071943
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