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Neural Correlates of Impaired Grasp Function in Children with Unilateral Spastic Cerebral Palsy
Unilateral spastic cerebral palsy (USCP) is caused by damage to the developing brain and affects motor function, mainly lateralized to one side of the body. Children with USCP have difficulties grasping objects, which can affect their ability to perform daily activities. Although cerebral palsy is t...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10377617/ https://www.ncbi.nlm.nih.gov/pubmed/37509032 http://dx.doi.org/10.3390/brainsci13071102 |
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author | Gutterman, Jennifer Gordon, Andrew M. |
author_facet | Gutterman, Jennifer Gordon, Andrew M. |
author_sort | Gutterman, Jennifer |
collection | PubMed |
description | Unilateral spastic cerebral palsy (USCP) is caused by damage to the developing brain and affects motor function, mainly lateralized to one side of the body. Children with USCP have difficulties grasping objects, which can affect their ability to perform daily activities. Although cerebral palsy is typically classified according to motor function, sensory abnormalities are often present as well and may contribute to motor impairments, including grasping. In this review, we show that the integrity and connectivity pattern of the corticospinal tract (CST) is related to execution and anticipatory control of grasping. However, as this may not explain all the variance of impairments in grasping function, we also describe the potential roles of sensory and sensorimotor integration deficits that contribute to grasp impairments. We highlight studies measuring fingertip forces during object manipulation tasks, as this approach allows for the dissection of the close association of sensory and motor function and can detect the discriminant use of sensory information during a complex, functional task (i.e., grasping). In addition, we discuss the importance of examining the interactions of the sensory and motor systems together, rather than in isolation. Finally, we suggest future directions for research to understand the underlying mechanisms of grasp impairments. |
format | Online Article Text |
id | pubmed-10377617 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-103776172023-07-29 Neural Correlates of Impaired Grasp Function in Children with Unilateral Spastic Cerebral Palsy Gutterman, Jennifer Gordon, Andrew M. Brain Sci Review Unilateral spastic cerebral palsy (USCP) is caused by damage to the developing brain and affects motor function, mainly lateralized to one side of the body. Children with USCP have difficulties grasping objects, which can affect their ability to perform daily activities. Although cerebral palsy is typically classified according to motor function, sensory abnormalities are often present as well and may contribute to motor impairments, including grasping. In this review, we show that the integrity and connectivity pattern of the corticospinal tract (CST) is related to execution and anticipatory control of grasping. However, as this may not explain all the variance of impairments in grasping function, we also describe the potential roles of sensory and sensorimotor integration deficits that contribute to grasp impairments. We highlight studies measuring fingertip forces during object manipulation tasks, as this approach allows for the dissection of the close association of sensory and motor function and can detect the discriminant use of sensory information during a complex, functional task (i.e., grasping). In addition, we discuss the importance of examining the interactions of the sensory and motor systems together, rather than in isolation. Finally, we suggest future directions for research to understand the underlying mechanisms of grasp impairments. MDPI 2023-07-21 /pmc/articles/PMC10377617/ /pubmed/37509032 http://dx.doi.org/10.3390/brainsci13071102 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Gutterman, Jennifer Gordon, Andrew M. Neural Correlates of Impaired Grasp Function in Children with Unilateral Spastic Cerebral Palsy |
title | Neural Correlates of Impaired Grasp Function in Children with Unilateral Spastic Cerebral Palsy |
title_full | Neural Correlates of Impaired Grasp Function in Children with Unilateral Spastic Cerebral Palsy |
title_fullStr | Neural Correlates of Impaired Grasp Function in Children with Unilateral Spastic Cerebral Palsy |
title_full_unstemmed | Neural Correlates of Impaired Grasp Function in Children with Unilateral Spastic Cerebral Palsy |
title_short | Neural Correlates of Impaired Grasp Function in Children with Unilateral Spastic Cerebral Palsy |
title_sort | neural correlates of impaired grasp function in children with unilateral spastic cerebral palsy |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10377617/ https://www.ncbi.nlm.nih.gov/pubmed/37509032 http://dx.doi.org/10.3390/brainsci13071102 |
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