Cargando…

Adenosine/β-Cyclodextrin-Based Metal–Organic Frameworks as a Potential Material for Cancer Therapy

Recently, researchers have employed metal–organic frameworks (MOFs) for loading pharmaceutically important substances. MOFs are a novel class of porous class of materials formed by the self-assembly of organic ligands and metal ions, creating a network structure. The current investigation effectivel...

Descripción completa

Detalles Bibliográficos
Autores principales: Rajamohan, Rajaram, Ashokkumar, Sekar, Murali Krishnan, Mani, Murugavel, Kuppusamy, Murugan, Moorthiraman, Lee, Yong Rok
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10377648/
https://www.ncbi.nlm.nih.gov/pubmed/37509190
http://dx.doi.org/10.3390/biom13071154
_version_ 1785079569624072192
author Rajamohan, Rajaram
Ashokkumar, Sekar
Murali Krishnan, Mani
Murugavel, Kuppusamy
Murugan, Moorthiraman
Lee, Yong Rok
author_facet Rajamohan, Rajaram
Ashokkumar, Sekar
Murali Krishnan, Mani
Murugavel, Kuppusamy
Murugan, Moorthiraman
Lee, Yong Rok
author_sort Rajamohan, Rajaram
collection PubMed
description Recently, researchers have employed metal–organic frameworks (MOFs) for loading pharmaceutically important substances. MOFs are a novel class of porous class of materials formed by the self-assembly of organic ligands and metal ions, creating a network structure. The current investigation effectively achieves the loading of adenosine (ADN) into a metal–organic framework based on cyclodextrin (CD) using a solvent diffusion method. The composite material, referred to as ADN:β-CD-K MOFs, is created by loading ADN into beta-cyclodextrin (β-CD) with the addition of K(+) salts. This study delves into the detailed examination of the interaction between ADN and β-CD in the form of MOFs. The focus is primarily on investigating the hydrogen bonding interaction and energy parameters through the aid of semi-empirical quantum mechanical computations. The analysis of peaks that are associated with the ADN-loaded ICs (inclusion complexes) within the MOFs indicates that ADN becomes incorporated into a partially amorphous state. Observations from SEM images reveal well-defined crystalline structures within the MOFs. Interestingly, when ADN is absent from the MOFs, smaller and irregularly shaped crystals are formed. This could potentially be attributed to the MOF manufacturing process. Furthermore, this study explores the additional cross-linking of β-CD with K through the coupling of -OH on the β-CD-K MOFs. The findings corroborate the results obtained from FT-IR analysis, suggesting that β-CD plays a crucial role as a seed in the creation of β-CD-K MOFs. Furthermore, the cytotoxicity of the MOFs is assessed in vitro using MDA-MB-231 cells (human breast cancer cells).
format Online
Article
Text
id pubmed-10377648
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-103776482023-07-29 Adenosine/β-Cyclodextrin-Based Metal–Organic Frameworks as a Potential Material for Cancer Therapy Rajamohan, Rajaram Ashokkumar, Sekar Murali Krishnan, Mani Murugavel, Kuppusamy Murugan, Moorthiraman Lee, Yong Rok Biomolecules Article Recently, researchers have employed metal–organic frameworks (MOFs) for loading pharmaceutically important substances. MOFs are a novel class of porous class of materials formed by the self-assembly of organic ligands and metal ions, creating a network structure. The current investigation effectively achieves the loading of adenosine (ADN) into a metal–organic framework based on cyclodextrin (CD) using a solvent diffusion method. The composite material, referred to as ADN:β-CD-K MOFs, is created by loading ADN into beta-cyclodextrin (β-CD) with the addition of K(+) salts. This study delves into the detailed examination of the interaction between ADN and β-CD in the form of MOFs. The focus is primarily on investigating the hydrogen bonding interaction and energy parameters through the aid of semi-empirical quantum mechanical computations. The analysis of peaks that are associated with the ADN-loaded ICs (inclusion complexes) within the MOFs indicates that ADN becomes incorporated into a partially amorphous state. Observations from SEM images reveal well-defined crystalline structures within the MOFs. Interestingly, when ADN is absent from the MOFs, smaller and irregularly shaped crystals are formed. This could potentially be attributed to the MOF manufacturing process. Furthermore, this study explores the additional cross-linking of β-CD with K through the coupling of -OH on the β-CD-K MOFs. The findings corroborate the results obtained from FT-IR analysis, suggesting that β-CD plays a crucial role as a seed in the creation of β-CD-K MOFs. Furthermore, the cytotoxicity of the MOFs is assessed in vitro using MDA-MB-231 cells (human breast cancer cells). MDPI 2023-07-20 /pmc/articles/PMC10377648/ /pubmed/37509190 http://dx.doi.org/10.3390/biom13071154 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Rajamohan, Rajaram
Ashokkumar, Sekar
Murali Krishnan, Mani
Murugavel, Kuppusamy
Murugan, Moorthiraman
Lee, Yong Rok
Adenosine/β-Cyclodextrin-Based Metal–Organic Frameworks as a Potential Material for Cancer Therapy
title Adenosine/β-Cyclodextrin-Based Metal–Organic Frameworks as a Potential Material for Cancer Therapy
title_full Adenosine/β-Cyclodextrin-Based Metal–Organic Frameworks as a Potential Material for Cancer Therapy
title_fullStr Adenosine/β-Cyclodextrin-Based Metal–Organic Frameworks as a Potential Material for Cancer Therapy
title_full_unstemmed Adenosine/β-Cyclodextrin-Based Metal–Organic Frameworks as a Potential Material for Cancer Therapy
title_short Adenosine/β-Cyclodextrin-Based Metal–Organic Frameworks as a Potential Material for Cancer Therapy
title_sort adenosine/β-cyclodextrin-based metal–organic frameworks as a potential material for cancer therapy
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10377648/
https://www.ncbi.nlm.nih.gov/pubmed/37509190
http://dx.doi.org/10.3390/biom13071154
work_keys_str_mv AT rajamohanrajaram adenosinebcyclodextrinbasedmetalorganicframeworksasapotentialmaterialforcancertherapy
AT ashokkumarsekar adenosinebcyclodextrinbasedmetalorganicframeworksasapotentialmaterialforcancertherapy
AT muralikrishnanmani adenosinebcyclodextrinbasedmetalorganicframeworksasapotentialmaterialforcancertherapy
AT murugavelkuppusamy adenosinebcyclodextrinbasedmetalorganicframeworksasapotentialmaterialforcancertherapy
AT muruganmoorthiraman adenosinebcyclodextrinbasedmetalorganicframeworksasapotentialmaterialforcancertherapy
AT leeyongrok adenosinebcyclodextrinbasedmetalorganicframeworksasapotentialmaterialforcancertherapy