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Microfluidic-Assisted Synthesis of Metal—Organic Framework —Alginate Micro-Particles for Sustained Drug Delivery

Drug delivery systems (DDS) are continuously being explored since humans are facing more numerous complicated diseases than ever before. These systems can preserve the drug’s functionality and improve its efficacy until the drug is delivered to a specific site within the body. One of the least used...

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Autores principales: Bendre, Akhilesh, Hegde, Vinayak, Ajeya, Kanalli V., Thagare Manjunatha, Subrahmanya, Somasekhara, Derangula, Nadumane, Varalakshmi K., Kant, Krishna, Jung, Ho-Young, Hung, Wei-Song, Kurkuri, Mahaveer D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10377693/
https://www.ncbi.nlm.nih.gov/pubmed/37504135
http://dx.doi.org/10.3390/bios13070737
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author Bendre, Akhilesh
Hegde, Vinayak
Ajeya, Kanalli V.
Thagare Manjunatha, Subrahmanya
Somasekhara, Derangula
Nadumane, Varalakshmi K.
Kant, Krishna
Jung, Ho-Young
Hung, Wei-Song
Kurkuri, Mahaveer D.
author_facet Bendre, Akhilesh
Hegde, Vinayak
Ajeya, Kanalli V.
Thagare Manjunatha, Subrahmanya
Somasekhara, Derangula
Nadumane, Varalakshmi K.
Kant, Krishna
Jung, Ho-Young
Hung, Wei-Song
Kurkuri, Mahaveer D.
author_sort Bendre, Akhilesh
collection PubMed
description Drug delivery systems (DDS) are continuously being explored since humans are facing more numerous complicated diseases than ever before. These systems can preserve the drug’s functionality and improve its efficacy until the drug is delivered to a specific site within the body. One of the least used materials for this purpose are metal—organic frameworks (MOFs). MOFs possess many properties, including their high surface area and the possibility for the addition of functional surface moieties, that make them ideal drug delivery vehicles. Such properties can be further improved by combining different materials (such as metals or ligands) and utilizing various synthesis techniques. In this work, the microfluidic technique is used to synthesize Zeolitic Imidazole Framework-67 (ZIF-67) containing cobalt ions as well as its bimetallic variant with cobalt and zinc as ZnZIF-67 to be subsequently loaded with diclofenac sodium and incorporated into sodium alginate beads for sustained drug delivery. This study shows the utilization of a microfluidic approach to synthesize MOF variants. Furthermore, these MOFs were incorporated into a biopolymer (sodium alginate) to produce a reliable DDS which can perform sustained drug releases for up to 6 days (for 90% of the full amount released), whereas MOFs without the biopolymer showed sudden release within the first day.
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spelling pubmed-103776932023-07-29 Microfluidic-Assisted Synthesis of Metal—Organic Framework —Alginate Micro-Particles for Sustained Drug Delivery Bendre, Akhilesh Hegde, Vinayak Ajeya, Kanalli V. Thagare Manjunatha, Subrahmanya Somasekhara, Derangula Nadumane, Varalakshmi K. Kant, Krishna Jung, Ho-Young Hung, Wei-Song Kurkuri, Mahaveer D. Biosensors (Basel) Article Drug delivery systems (DDS) are continuously being explored since humans are facing more numerous complicated diseases than ever before. These systems can preserve the drug’s functionality and improve its efficacy until the drug is delivered to a specific site within the body. One of the least used materials for this purpose are metal—organic frameworks (MOFs). MOFs possess many properties, including their high surface area and the possibility for the addition of functional surface moieties, that make them ideal drug delivery vehicles. Such properties can be further improved by combining different materials (such as metals or ligands) and utilizing various synthesis techniques. In this work, the microfluidic technique is used to synthesize Zeolitic Imidazole Framework-67 (ZIF-67) containing cobalt ions as well as its bimetallic variant with cobalt and zinc as ZnZIF-67 to be subsequently loaded with diclofenac sodium and incorporated into sodium alginate beads for sustained drug delivery. This study shows the utilization of a microfluidic approach to synthesize MOF variants. Furthermore, these MOFs were incorporated into a biopolymer (sodium alginate) to produce a reliable DDS which can perform sustained drug releases for up to 6 days (for 90% of the full amount released), whereas MOFs without the biopolymer showed sudden release within the first day. MDPI 2023-07-17 /pmc/articles/PMC10377693/ /pubmed/37504135 http://dx.doi.org/10.3390/bios13070737 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Bendre, Akhilesh
Hegde, Vinayak
Ajeya, Kanalli V.
Thagare Manjunatha, Subrahmanya
Somasekhara, Derangula
Nadumane, Varalakshmi K.
Kant, Krishna
Jung, Ho-Young
Hung, Wei-Song
Kurkuri, Mahaveer D.
Microfluidic-Assisted Synthesis of Metal—Organic Framework —Alginate Micro-Particles for Sustained Drug Delivery
title Microfluidic-Assisted Synthesis of Metal—Organic Framework —Alginate Micro-Particles for Sustained Drug Delivery
title_full Microfluidic-Assisted Synthesis of Metal—Organic Framework —Alginate Micro-Particles for Sustained Drug Delivery
title_fullStr Microfluidic-Assisted Synthesis of Metal—Organic Framework —Alginate Micro-Particles for Sustained Drug Delivery
title_full_unstemmed Microfluidic-Assisted Synthesis of Metal—Organic Framework —Alginate Micro-Particles for Sustained Drug Delivery
title_short Microfluidic-Assisted Synthesis of Metal—Organic Framework —Alginate Micro-Particles for Sustained Drug Delivery
title_sort microfluidic-assisted synthesis of metal—organic framework —alginate micro-particles for sustained drug delivery
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10377693/
https://www.ncbi.nlm.nih.gov/pubmed/37504135
http://dx.doi.org/10.3390/bios13070737
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