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Does Therapeutic Exercise Support Improvement in Cognitive Function and Instrumental Activities of Daily Living in Patients with Mild Alzheimer’s Disease? A Randomized Controlled Trial
This randomized controlled trial aims to investigate the effect of 12 weeks of therapeutic exercise on cognitive function and daily activities in patients with mild Alzheimer’s disease (AD). A total of 171 patients with mild AD from the Amarousion Day Care Center of the Alzheimer Society of Athens a...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10377697/ https://www.ncbi.nlm.nih.gov/pubmed/37509042 http://dx.doi.org/10.3390/brainsci13071112 |
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author | Papatsimpas, Vasileios Vrouva, Sotiria Papathanasiou, George Papadopoulou, Marianna Bouzineki, Christina Kanellopoulou, Sophia Moutafi, Dimitra Bakalidou, Daphne |
author_facet | Papatsimpas, Vasileios Vrouva, Sotiria Papathanasiou, George Papadopoulou, Marianna Bouzineki, Christina Kanellopoulou, Sophia Moutafi, Dimitra Bakalidou, Daphne |
author_sort | Papatsimpas, Vasileios |
collection | PubMed |
description | This randomized controlled trial aims to investigate the effect of 12 weeks of therapeutic exercise on cognitive function and daily activities in patients with mild Alzheimer’s disease (AD). A total of 171 patients with mild AD from the Amarousion Day Care Center of the Alzheimer Society of Athens and the Athens General Hospital “G. Gennimatas” were randomly divided into three groups. Group A (aerobic and resistance exercise, n = 57), group B (resistance exercise, n = 57), and group C (control group, n = 57). Group A followed a weekly program consisting of 5 days with 30 min walking and 3 days with resistance exercises for about 45 min. Group B followed only a resistance exercise program, the same as group A. Group C did not participate in any exercise program. After the intervention, cognitive function was assessed with the Cognitive Examination-Revised (ACE-R), Trail Making Test A-B (TMT A-B), and Digit Span Test Forward and Backward (DST F-B) and daily activities with the instrumental activities of daily living scale (IADLs). A significant intervention effect was observed for all outcome measures (global cognitive function and instrumental activities of daily living). ANCOVA Bonferroni corrected post hoc tests revealed that the aerobic and resistance group improved compared to the control group on all measurement scales. The resistance group also showed an improvement compared to the control group. No significant effects were found between the aerobic and resistance group and the resistance group in any of the outcome measures. |
format | Online Article Text |
id | pubmed-10377697 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-103776972023-07-29 Does Therapeutic Exercise Support Improvement in Cognitive Function and Instrumental Activities of Daily Living in Patients with Mild Alzheimer’s Disease? A Randomized Controlled Trial Papatsimpas, Vasileios Vrouva, Sotiria Papathanasiou, George Papadopoulou, Marianna Bouzineki, Christina Kanellopoulou, Sophia Moutafi, Dimitra Bakalidou, Daphne Brain Sci Article This randomized controlled trial aims to investigate the effect of 12 weeks of therapeutic exercise on cognitive function and daily activities in patients with mild Alzheimer’s disease (AD). A total of 171 patients with mild AD from the Amarousion Day Care Center of the Alzheimer Society of Athens and the Athens General Hospital “G. Gennimatas” were randomly divided into three groups. Group A (aerobic and resistance exercise, n = 57), group B (resistance exercise, n = 57), and group C (control group, n = 57). Group A followed a weekly program consisting of 5 days with 30 min walking and 3 days with resistance exercises for about 45 min. Group B followed only a resistance exercise program, the same as group A. Group C did not participate in any exercise program. After the intervention, cognitive function was assessed with the Cognitive Examination-Revised (ACE-R), Trail Making Test A-B (TMT A-B), and Digit Span Test Forward and Backward (DST F-B) and daily activities with the instrumental activities of daily living scale (IADLs). A significant intervention effect was observed for all outcome measures (global cognitive function and instrumental activities of daily living). ANCOVA Bonferroni corrected post hoc tests revealed that the aerobic and resistance group improved compared to the control group on all measurement scales. The resistance group also showed an improvement compared to the control group. No significant effects were found between the aerobic and resistance group and the resistance group in any of the outcome measures. MDPI 2023-07-22 /pmc/articles/PMC10377697/ /pubmed/37509042 http://dx.doi.org/10.3390/brainsci13071112 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Papatsimpas, Vasileios Vrouva, Sotiria Papathanasiou, George Papadopoulou, Marianna Bouzineki, Christina Kanellopoulou, Sophia Moutafi, Dimitra Bakalidou, Daphne Does Therapeutic Exercise Support Improvement in Cognitive Function and Instrumental Activities of Daily Living in Patients with Mild Alzheimer’s Disease? A Randomized Controlled Trial |
title | Does Therapeutic Exercise Support Improvement in Cognitive Function and Instrumental Activities of Daily Living in Patients with Mild Alzheimer’s Disease? A Randomized Controlled Trial |
title_full | Does Therapeutic Exercise Support Improvement in Cognitive Function and Instrumental Activities of Daily Living in Patients with Mild Alzheimer’s Disease? A Randomized Controlled Trial |
title_fullStr | Does Therapeutic Exercise Support Improvement in Cognitive Function and Instrumental Activities of Daily Living in Patients with Mild Alzheimer’s Disease? A Randomized Controlled Trial |
title_full_unstemmed | Does Therapeutic Exercise Support Improvement in Cognitive Function and Instrumental Activities of Daily Living in Patients with Mild Alzheimer’s Disease? A Randomized Controlled Trial |
title_short | Does Therapeutic Exercise Support Improvement in Cognitive Function and Instrumental Activities of Daily Living in Patients with Mild Alzheimer’s Disease? A Randomized Controlled Trial |
title_sort | does therapeutic exercise support improvement in cognitive function and instrumental activities of daily living in patients with mild alzheimer’s disease? a randomized controlled trial |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10377697/ https://www.ncbi.nlm.nih.gov/pubmed/37509042 http://dx.doi.org/10.3390/brainsci13071112 |
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