Cargando…

The Enigmatic CA2: Exploring the Understudied Region of the Hippocampus and Its Involvement in Parkinson’s Disease

Parkinson’s disease (PD) is a neurodegenerative disease that affects both motor and non-motor functions. Although motor impairment is a prominent clinical sign of PD, additional neurological symptoms may also occur, particularly in the preclinical and prodromal stages. Among these symptoms, social c...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhao, Fang, Behnisch, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10377725/
https://www.ncbi.nlm.nih.gov/pubmed/37509636
http://dx.doi.org/10.3390/biomedicines11071996
_version_ 1785079588979736576
author Zhao, Fang
Behnisch, Thomas
author_facet Zhao, Fang
Behnisch, Thomas
author_sort Zhao, Fang
collection PubMed
description Parkinson’s disease (PD) is a neurodegenerative disease that affects both motor and non-motor functions. Although motor impairment is a prominent clinical sign of PD, additional neurological symptoms may also occur, particularly in the preclinical and prodromal stages. Among these symptoms, social cognitive impairment is common and detrimental. This article aims to review non-motor symptoms in PD patients, focusing on social cognitive deficits. It also examines the specific characteristics of the CA2 region and its involvement in social behavior, highlighting recent advances and perspectives. Additionally, this review provides critical insights into and analysis of research conducted in rodents and humans, which may help improve the understanding of the current status of putative therapeutic strategies for social cognitive dysfunction in PD and potential avenues related to the function of the hippocampal CA2 region.
format Online
Article
Text
id pubmed-10377725
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-103777252023-07-29 The Enigmatic CA2: Exploring the Understudied Region of the Hippocampus and Its Involvement in Parkinson’s Disease Zhao, Fang Behnisch, Thomas Biomedicines Review Parkinson’s disease (PD) is a neurodegenerative disease that affects both motor and non-motor functions. Although motor impairment is a prominent clinical sign of PD, additional neurological symptoms may also occur, particularly in the preclinical and prodromal stages. Among these symptoms, social cognitive impairment is common and detrimental. This article aims to review non-motor symptoms in PD patients, focusing on social cognitive deficits. It also examines the specific characteristics of the CA2 region and its involvement in social behavior, highlighting recent advances and perspectives. Additionally, this review provides critical insights into and analysis of research conducted in rodents and humans, which may help improve the understanding of the current status of putative therapeutic strategies for social cognitive dysfunction in PD and potential avenues related to the function of the hippocampal CA2 region. MDPI 2023-07-14 /pmc/articles/PMC10377725/ /pubmed/37509636 http://dx.doi.org/10.3390/biomedicines11071996 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Zhao, Fang
Behnisch, Thomas
The Enigmatic CA2: Exploring the Understudied Region of the Hippocampus and Its Involvement in Parkinson’s Disease
title The Enigmatic CA2: Exploring the Understudied Region of the Hippocampus and Its Involvement in Parkinson’s Disease
title_full The Enigmatic CA2: Exploring the Understudied Region of the Hippocampus and Its Involvement in Parkinson’s Disease
title_fullStr The Enigmatic CA2: Exploring the Understudied Region of the Hippocampus and Its Involvement in Parkinson’s Disease
title_full_unstemmed The Enigmatic CA2: Exploring the Understudied Region of the Hippocampus and Its Involvement in Parkinson’s Disease
title_short The Enigmatic CA2: Exploring the Understudied Region of the Hippocampus and Its Involvement in Parkinson’s Disease
title_sort enigmatic ca2: exploring the understudied region of the hippocampus and its involvement in parkinson’s disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10377725/
https://www.ncbi.nlm.nih.gov/pubmed/37509636
http://dx.doi.org/10.3390/biomedicines11071996
work_keys_str_mv AT zhaofang theenigmaticca2exploringtheunderstudiedregionofthehippocampusanditsinvolvementinparkinsonsdisease
AT behnischthomas theenigmaticca2exploringtheunderstudiedregionofthehippocampusanditsinvolvementinparkinsonsdisease
AT zhaofang enigmaticca2exploringtheunderstudiedregionofthehippocampusanditsinvolvementinparkinsonsdisease
AT behnischthomas enigmaticca2exploringtheunderstudiedregionofthehippocampusanditsinvolvementinparkinsonsdisease