Pharmacokinetic and pharmacodynamic properties of polymyxin B in Escherichia coli and Klebsiella pneumoniae murine infection models

BACKGROUND: Although polymyxin B has been in use since the late 1950s, there have been limited studies done to unravel its pharmacokinetics (PK) and pharmacodynamics (PD) index. METHODS: We determined, in neutropenic infected mice, the PK, plasma protein binding and PK/PD index best correlating with...

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Detalles Bibliográficos
Autores principales: van der Meijden, Aart, Aranzana-Climent, Vincent, van der Spek, Heleen, de Winter, Brenda C M, Couet, William, Meletiadis, Joseph, Muller, Anouk E, van den Berg, Sanne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10377753/
https://www.ncbi.nlm.nih.gov/pubmed/36718051
http://dx.doi.org/10.1093/jac/dkad022

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