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Velocity Time Integral: A Novel Method for Assessing Fetal Anemia

The velocity time integral (VTI) is a clinical Doppler ultrasound measurement of blood flow, measured by the area under the wave curve and equivalent to the distance traveled by the blood. This retrospective study assessed the middle cerebral artery (MCA) VTI of fetuses in pregnancies complicated by...

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Autores principales: Piura, Ettie, Engel, Offra, Doctory, Neta, Arbib, Nisim, Biron-Shental, Tal, Kovo, Michal, Arnon, Shmuel, Markovitch, Ofer
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10377850/
https://www.ncbi.nlm.nih.gov/pubmed/37508587
http://dx.doi.org/10.3390/children10071090
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author Piura, Ettie
Engel, Offra
Doctory, Neta
Arbib, Nisim
Biron-Shental, Tal
Kovo, Michal
Arnon, Shmuel
Markovitch, Ofer
author_facet Piura, Ettie
Engel, Offra
Doctory, Neta
Arbib, Nisim
Biron-Shental, Tal
Kovo, Michal
Arnon, Shmuel
Markovitch, Ofer
author_sort Piura, Ettie
collection PubMed
description The velocity time integral (VTI) is a clinical Doppler ultrasound measurement of blood flow, measured by the area under the wave curve and equivalent to the distance traveled by the blood. This retrospective study assessed the middle cerebral artery (MCA) VTI of fetuses in pregnancies complicated by maternal alloimmunization. Doppler indices of the MCA were retrieved from electronic medical records. Systolic deceleration-diastolic time, systolic acceleration time, VTI, and peak systolic velocity (PSV) were measured at 16–40 weeks gestation. Cases with PSV indicating fetal anemia (cutoff 1.5 MoM) and normal PSV were compared. The study included 255 Doppler ultrasound examinations. Of these, 41 were at 16–24 weeks (group A), 100 were at 25–32 weeks (group B), and 114 were at 33–40 weeks (group C). VTI increased throughout gestation (5.5 cm, 8.6 cm, and 12.1 cm in groups A, B, and C, respectively, p = 0.003). VTI was higher in waveforms calculated to have MCA-PSV ≥ 1.5 MoM compared to those with MCA-PSV < 1.5 MoM (9.1 cm vs. 14.1 cm, respectively, p < 0.001), as was VTI/s (22.04 cm/s vs. 33.75 cm/s, respectively; p < 0.001). The results indicate that the MCA VTI increases significantly among fetuses with suspected anemia, indicating higher perfusion of hemodiluted blood to the brain. This feasible measurement might provide a novel additional marker for the development of fetal anemia.
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spelling pubmed-103778502023-07-29 Velocity Time Integral: A Novel Method for Assessing Fetal Anemia Piura, Ettie Engel, Offra Doctory, Neta Arbib, Nisim Biron-Shental, Tal Kovo, Michal Arnon, Shmuel Markovitch, Ofer Children (Basel) Article The velocity time integral (VTI) is a clinical Doppler ultrasound measurement of blood flow, measured by the area under the wave curve and equivalent to the distance traveled by the blood. This retrospective study assessed the middle cerebral artery (MCA) VTI of fetuses in pregnancies complicated by maternal alloimmunization. Doppler indices of the MCA were retrieved from electronic medical records. Systolic deceleration-diastolic time, systolic acceleration time, VTI, and peak systolic velocity (PSV) were measured at 16–40 weeks gestation. Cases with PSV indicating fetal anemia (cutoff 1.5 MoM) and normal PSV were compared. The study included 255 Doppler ultrasound examinations. Of these, 41 were at 16–24 weeks (group A), 100 were at 25–32 weeks (group B), and 114 were at 33–40 weeks (group C). VTI increased throughout gestation (5.5 cm, 8.6 cm, and 12.1 cm in groups A, B, and C, respectively, p = 0.003). VTI was higher in waveforms calculated to have MCA-PSV ≥ 1.5 MoM compared to those with MCA-PSV < 1.5 MoM (9.1 cm vs. 14.1 cm, respectively, p < 0.001), as was VTI/s (22.04 cm/s vs. 33.75 cm/s, respectively; p < 0.001). The results indicate that the MCA VTI increases significantly among fetuses with suspected anemia, indicating higher perfusion of hemodiluted blood to the brain. This feasible measurement might provide a novel additional marker for the development of fetal anemia. MDPI 2023-06-21 /pmc/articles/PMC10377850/ /pubmed/37508587 http://dx.doi.org/10.3390/children10071090 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Piura, Ettie
Engel, Offra
Doctory, Neta
Arbib, Nisim
Biron-Shental, Tal
Kovo, Michal
Arnon, Shmuel
Markovitch, Ofer
Velocity Time Integral: A Novel Method for Assessing Fetal Anemia
title Velocity Time Integral: A Novel Method for Assessing Fetal Anemia
title_full Velocity Time Integral: A Novel Method for Assessing Fetal Anemia
title_fullStr Velocity Time Integral: A Novel Method for Assessing Fetal Anemia
title_full_unstemmed Velocity Time Integral: A Novel Method for Assessing Fetal Anemia
title_short Velocity Time Integral: A Novel Method for Assessing Fetal Anemia
title_sort velocity time integral: a novel method for assessing fetal anemia
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10377850/
https://www.ncbi.nlm.nih.gov/pubmed/37508587
http://dx.doi.org/10.3390/children10071090
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