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Triiodothyronine and Protein Malnutrition Could Influence Pulse Wave Velocity in Pre-Dialysis Chronic Kidney Disease Patients

Cardiovascular diseases (CVD) are the first cause of chronic kidney disease (CKD) mortality. For personalized improved medicine, detecting correctable markers of CVD can be considered a priority. The aim of this study was the evaluation of the impact of nutritional, hormonal and inflammatory markers...

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Autores principales: Rusu, Crina Claudia, Kacso, Ina, Moldovan, Diana, Potra, Alina, Tirinescu, Dacian, Ticala, Maria, Rotar, Ancuta M., Orasan, Remus, Budurea, Cristian, Barar, Andrada, Anton, Florin, Valea, Ana, Bondor, Cosmina Ioana, Ticolea, Madalina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10377851/
https://www.ncbi.nlm.nih.gov/pubmed/37510208
http://dx.doi.org/10.3390/diagnostics13142462
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author Rusu, Crina Claudia
Kacso, Ina
Moldovan, Diana
Potra, Alina
Tirinescu, Dacian
Ticala, Maria
Rotar, Ancuta M.
Orasan, Remus
Budurea, Cristian
Barar, Andrada
Anton, Florin
Valea, Ana
Bondor, Cosmina Ioana
Ticolea, Madalina
author_facet Rusu, Crina Claudia
Kacso, Ina
Moldovan, Diana
Potra, Alina
Tirinescu, Dacian
Ticala, Maria
Rotar, Ancuta M.
Orasan, Remus
Budurea, Cristian
Barar, Andrada
Anton, Florin
Valea, Ana
Bondor, Cosmina Ioana
Ticolea, Madalina
author_sort Rusu, Crina Claudia
collection PubMed
description Cardiovascular diseases (CVD) are the first cause of chronic kidney disease (CKD) mortality. For personalized improved medicine, detecting correctable markers of CVD can be considered a priority. The aim of this study was the evaluation of the impact of nutritional, hormonal and inflammatory markers on brachial-ankle Pulse Wave Velocity (PWV) in pre-dialysis CKD patients. A cross-sectional observational study was conducted on 68 pre-dialysis CKD patients (median age of 69 years, 41.2% with diabetes mellitus, 52.9% male). Laboratory data were collected, including levels of prolactin, triiodothyronine, TGF α, IL-6, and IL-1β. The high values of brachial-ankle PWV were associated with reduced muscle mass (p = 0.001, r = −0.44), low levels of total cholesterol (p = 0.04, r = −0.26), triglycerides (p = 0.03, r = −0.31), triiodothyronine (p = 0.04, r = −0.24), and prolactin (p = 0.02, r = −0.27). High PWV was associated with advanced age (p < 0.001, r = 0.19). In the multivariate analysis, reduced muscle mass (p = 0.018), low levels of triiodothyronine (p = 0.002), and triglycerides (p = 0.049) were significant predictors of PWV, but age (p < 0.001) remained an important factor. In conclusion, reduced triiodothyronine together with markers of malnutrition and age were associated with PWV in pre-dialysis CKD patients.
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spelling pubmed-103778512023-07-29 Triiodothyronine and Protein Malnutrition Could Influence Pulse Wave Velocity in Pre-Dialysis Chronic Kidney Disease Patients Rusu, Crina Claudia Kacso, Ina Moldovan, Diana Potra, Alina Tirinescu, Dacian Ticala, Maria Rotar, Ancuta M. Orasan, Remus Budurea, Cristian Barar, Andrada Anton, Florin Valea, Ana Bondor, Cosmina Ioana Ticolea, Madalina Diagnostics (Basel) Article Cardiovascular diseases (CVD) are the first cause of chronic kidney disease (CKD) mortality. For personalized improved medicine, detecting correctable markers of CVD can be considered a priority. The aim of this study was the evaluation of the impact of nutritional, hormonal and inflammatory markers on brachial-ankle Pulse Wave Velocity (PWV) in pre-dialysis CKD patients. A cross-sectional observational study was conducted on 68 pre-dialysis CKD patients (median age of 69 years, 41.2% with diabetes mellitus, 52.9% male). Laboratory data were collected, including levels of prolactin, triiodothyronine, TGF α, IL-6, and IL-1β. The high values of brachial-ankle PWV were associated with reduced muscle mass (p = 0.001, r = −0.44), low levels of total cholesterol (p = 0.04, r = −0.26), triglycerides (p = 0.03, r = −0.31), triiodothyronine (p = 0.04, r = −0.24), and prolactin (p = 0.02, r = −0.27). High PWV was associated with advanced age (p < 0.001, r = 0.19). In the multivariate analysis, reduced muscle mass (p = 0.018), low levels of triiodothyronine (p = 0.002), and triglycerides (p = 0.049) were significant predictors of PWV, but age (p < 0.001) remained an important factor. In conclusion, reduced triiodothyronine together with markers of malnutrition and age were associated with PWV in pre-dialysis CKD patients. MDPI 2023-07-24 /pmc/articles/PMC10377851/ /pubmed/37510208 http://dx.doi.org/10.3390/diagnostics13142462 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Rusu, Crina Claudia
Kacso, Ina
Moldovan, Diana
Potra, Alina
Tirinescu, Dacian
Ticala, Maria
Rotar, Ancuta M.
Orasan, Remus
Budurea, Cristian
Barar, Andrada
Anton, Florin
Valea, Ana
Bondor, Cosmina Ioana
Ticolea, Madalina
Triiodothyronine and Protein Malnutrition Could Influence Pulse Wave Velocity in Pre-Dialysis Chronic Kidney Disease Patients
title Triiodothyronine and Protein Malnutrition Could Influence Pulse Wave Velocity in Pre-Dialysis Chronic Kidney Disease Patients
title_full Triiodothyronine and Protein Malnutrition Could Influence Pulse Wave Velocity in Pre-Dialysis Chronic Kidney Disease Patients
title_fullStr Triiodothyronine and Protein Malnutrition Could Influence Pulse Wave Velocity in Pre-Dialysis Chronic Kidney Disease Patients
title_full_unstemmed Triiodothyronine and Protein Malnutrition Could Influence Pulse Wave Velocity in Pre-Dialysis Chronic Kidney Disease Patients
title_short Triiodothyronine and Protein Malnutrition Could Influence Pulse Wave Velocity in Pre-Dialysis Chronic Kidney Disease Patients
title_sort triiodothyronine and protein malnutrition could influence pulse wave velocity in pre-dialysis chronic kidney disease patients
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10377851/
https://www.ncbi.nlm.nih.gov/pubmed/37510208
http://dx.doi.org/10.3390/diagnostics13142462
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