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Triiodothyronine and Protein Malnutrition Could Influence Pulse Wave Velocity in Pre-Dialysis Chronic Kidney Disease Patients
Cardiovascular diseases (CVD) are the first cause of chronic kidney disease (CKD) mortality. For personalized improved medicine, detecting correctable markers of CVD can be considered a priority. The aim of this study was the evaluation of the impact of nutritional, hormonal and inflammatory markers...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10377851/ https://www.ncbi.nlm.nih.gov/pubmed/37510208 http://dx.doi.org/10.3390/diagnostics13142462 |
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author | Rusu, Crina Claudia Kacso, Ina Moldovan, Diana Potra, Alina Tirinescu, Dacian Ticala, Maria Rotar, Ancuta M. Orasan, Remus Budurea, Cristian Barar, Andrada Anton, Florin Valea, Ana Bondor, Cosmina Ioana Ticolea, Madalina |
author_facet | Rusu, Crina Claudia Kacso, Ina Moldovan, Diana Potra, Alina Tirinescu, Dacian Ticala, Maria Rotar, Ancuta M. Orasan, Remus Budurea, Cristian Barar, Andrada Anton, Florin Valea, Ana Bondor, Cosmina Ioana Ticolea, Madalina |
author_sort | Rusu, Crina Claudia |
collection | PubMed |
description | Cardiovascular diseases (CVD) are the first cause of chronic kidney disease (CKD) mortality. For personalized improved medicine, detecting correctable markers of CVD can be considered a priority. The aim of this study was the evaluation of the impact of nutritional, hormonal and inflammatory markers on brachial-ankle Pulse Wave Velocity (PWV) in pre-dialysis CKD patients. A cross-sectional observational study was conducted on 68 pre-dialysis CKD patients (median age of 69 years, 41.2% with diabetes mellitus, 52.9% male). Laboratory data were collected, including levels of prolactin, triiodothyronine, TGF α, IL-6, and IL-1β. The high values of brachial-ankle PWV were associated with reduced muscle mass (p = 0.001, r = −0.44), low levels of total cholesterol (p = 0.04, r = −0.26), triglycerides (p = 0.03, r = −0.31), triiodothyronine (p = 0.04, r = −0.24), and prolactin (p = 0.02, r = −0.27). High PWV was associated with advanced age (p < 0.001, r = 0.19). In the multivariate analysis, reduced muscle mass (p = 0.018), low levels of triiodothyronine (p = 0.002), and triglycerides (p = 0.049) were significant predictors of PWV, but age (p < 0.001) remained an important factor. In conclusion, reduced triiodothyronine together with markers of malnutrition and age were associated with PWV in pre-dialysis CKD patients. |
format | Online Article Text |
id | pubmed-10377851 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-103778512023-07-29 Triiodothyronine and Protein Malnutrition Could Influence Pulse Wave Velocity in Pre-Dialysis Chronic Kidney Disease Patients Rusu, Crina Claudia Kacso, Ina Moldovan, Diana Potra, Alina Tirinescu, Dacian Ticala, Maria Rotar, Ancuta M. Orasan, Remus Budurea, Cristian Barar, Andrada Anton, Florin Valea, Ana Bondor, Cosmina Ioana Ticolea, Madalina Diagnostics (Basel) Article Cardiovascular diseases (CVD) are the first cause of chronic kidney disease (CKD) mortality. For personalized improved medicine, detecting correctable markers of CVD can be considered a priority. The aim of this study was the evaluation of the impact of nutritional, hormonal and inflammatory markers on brachial-ankle Pulse Wave Velocity (PWV) in pre-dialysis CKD patients. A cross-sectional observational study was conducted on 68 pre-dialysis CKD patients (median age of 69 years, 41.2% with diabetes mellitus, 52.9% male). Laboratory data were collected, including levels of prolactin, triiodothyronine, TGF α, IL-6, and IL-1β. The high values of brachial-ankle PWV were associated with reduced muscle mass (p = 0.001, r = −0.44), low levels of total cholesterol (p = 0.04, r = −0.26), triglycerides (p = 0.03, r = −0.31), triiodothyronine (p = 0.04, r = −0.24), and prolactin (p = 0.02, r = −0.27). High PWV was associated with advanced age (p < 0.001, r = 0.19). In the multivariate analysis, reduced muscle mass (p = 0.018), low levels of triiodothyronine (p = 0.002), and triglycerides (p = 0.049) were significant predictors of PWV, but age (p < 0.001) remained an important factor. In conclusion, reduced triiodothyronine together with markers of malnutrition and age were associated with PWV in pre-dialysis CKD patients. MDPI 2023-07-24 /pmc/articles/PMC10377851/ /pubmed/37510208 http://dx.doi.org/10.3390/diagnostics13142462 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Rusu, Crina Claudia Kacso, Ina Moldovan, Diana Potra, Alina Tirinescu, Dacian Ticala, Maria Rotar, Ancuta M. Orasan, Remus Budurea, Cristian Barar, Andrada Anton, Florin Valea, Ana Bondor, Cosmina Ioana Ticolea, Madalina Triiodothyronine and Protein Malnutrition Could Influence Pulse Wave Velocity in Pre-Dialysis Chronic Kidney Disease Patients |
title | Triiodothyronine and Protein Malnutrition Could Influence Pulse Wave Velocity in Pre-Dialysis Chronic Kidney Disease Patients |
title_full | Triiodothyronine and Protein Malnutrition Could Influence Pulse Wave Velocity in Pre-Dialysis Chronic Kidney Disease Patients |
title_fullStr | Triiodothyronine and Protein Malnutrition Could Influence Pulse Wave Velocity in Pre-Dialysis Chronic Kidney Disease Patients |
title_full_unstemmed | Triiodothyronine and Protein Malnutrition Could Influence Pulse Wave Velocity in Pre-Dialysis Chronic Kidney Disease Patients |
title_short | Triiodothyronine and Protein Malnutrition Could Influence Pulse Wave Velocity in Pre-Dialysis Chronic Kidney Disease Patients |
title_sort | triiodothyronine and protein malnutrition could influence pulse wave velocity in pre-dialysis chronic kidney disease patients |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10377851/ https://www.ncbi.nlm.nih.gov/pubmed/37510208 http://dx.doi.org/10.3390/diagnostics13142462 |
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