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The Integral Role of Diets Including Natural Products to Manage Rheumatoid Arthritis: A Narrative Review

Genetic and environmental factors including lifestyle are thought to play a key role in the pathophysiology of rheumatoid arthritis (RA). There is evidence that diet can enhance the inflammatory response in genetically predisposed individuals. On the other hand, certain types of diets can alleviate...

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Autores principales: Gunes-Bayir, Ayse, Mendes, Beyza, Dadak, Agnes
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10377866/
https://www.ncbi.nlm.nih.gov/pubmed/37504257
http://dx.doi.org/10.3390/cimb45070341
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author Gunes-Bayir, Ayse
Mendes, Beyza
Dadak, Agnes
author_facet Gunes-Bayir, Ayse
Mendes, Beyza
Dadak, Agnes
author_sort Gunes-Bayir, Ayse
collection PubMed
description Genetic and environmental factors including lifestyle are thought to play a key role in the pathophysiology of rheumatoid arthritis (RA). There is evidence that diet can enhance the inflammatory response in genetically predisposed individuals. On the other hand, certain types of diets can alleviate RA symptoms due to their anti-inflammatory and antioxidant activities. Also, natural compounds with potential effectiveness in RA management belong to different chemical classes such as flavonoids, polyphenols, carotenoids, and alkaloids with their antioxidant characteristics as well as probiotics. The nutritional approaches to prevent or extenuate the disease progress were examined in this narrative review which was conducted using the PubMed, ScienceDirect and Google Scholar databases and conforms to the Scale for the Assessment of Narrative Review Articles (SANRA) guidelines. Mediterranean and vegan diets equally have been shown to exhibit positive effects on RA as the consumption of dietary fiber, antioxidants and anti-inflammatory compounds from fruits, vegetables, grains, nuts, and seeds are high. Whereas Mediterranean diet additionally includes beneficial nutrients of animal origin such as omega-3 polyunsaturated fatty acids from fish and seafood, patients on vegan diet need to be monitored closely for intake of all critical nutrients. Certain calorie restrictions and intermittent fasting diets have been shown to benefit RA patients although there is an obvious need for further studies to establish solid evidence-based recommendations and guidelines. The research data available strongly suggest that dietary approaches with anti-inflammatory properties may help delay the onset of RA and/or improve symptoms and thus nutrition should be routinely addressed to facilitate management of the disease.
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spelling pubmed-103778662023-07-29 The Integral Role of Diets Including Natural Products to Manage Rheumatoid Arthritis: A Narrative Review Gunes-Bayir, Ayse Mendes, Beyza Dadak, Agnes Curr Issues Mol Biol Review Genetic and environmental factors including lifestyle are thought to play a key role in the pathophysiology of rheumatoid arthritis (RA). There is evidence that diet can enhance the inflammatory response in genetically predisposed individuals. On the other hand, certain types of diets can alleviate RA symptoms due to their anti-inflammatory and antioxidant activities. Also, natural compounds with potential effectiveness in RA management belong to different chemical classes such as flavonoids, polyphenols, carotenoids, and alkaloids with their antioxidant characteristics as well as probiotics. The nutritional approaches to prevent or extenuate the disease progress were examined in this narrative review which was conducted using the PubMed, ScienceDirect and Google Scholar databases and conforms to the Scale for the Assessment of Narrative Review Articles (SANRA) guidelines. Mediterranean and vegan diets equally have been shown to exhibit positive effects on RA as the consumption of dietary fiber, antioxidants and anti-inflammatory compounds from fruits, vegetables, grains, nuts, and seeds are high. Whereas Mediterranean diet additionally includes beneficial nutrients of animal origin such as omega-3 polyunsaturated fatty acids from fish and seafood, patients on vegan diet need to be monitored closely for intake of all critical nutrients. Certain calorie restrictions and intermittent fasting diets have been shown to benefit RA patients although there is an obvious need for further studies to establish solid evidence-based recommendations and guidelines. The research data available strongly suggest that dietary approaches with anti-inflammatory properties may help delay the onset of RA and/or improve symptoms and thus nutrition should be routinely addressed to facilitate management of the disease. MDPI 2023-06-28 /pmc/articles/PMC10377866/ /pubmed/37504257 http://dx.doi.org/10.3390/cimb45070341 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Gunes-Bayir, Ayse
Mendes, Beyza
Dadak, Agnes
The Integral Role of Diets Including Natural Products to Manage Rheumatoid Arthritis: A Narrative Review
title The Integral Role of Diets Including Natural Products to Manage Rheumatoid Arthritis: A Narrative Review
title_full The Integral Role of Diets Including Natural Products to Manage Rheumatoid Arthritis: A Narrative Review
title_fullStr The Integral Role of Diets Including Natural Products to Manage Rheumatoid Arthritis: A Narrative Review
title_full_unstemmed The Integral Role of Diets Including Natural Products to Manage Rheumatoid Arthritis: A Narrative Review
title_short The Integral Role of Diets Including Natural Products to Manage Rheumatoid Arthritis: A Narrative Review
title_sort integral role of diets including natural products to manage rheumatoid arthritis: a narrative review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10377866/
https://www.ncbi.nlm.nih.gov/pubmed/37504257
http://dx.doi.org/10.3390/cimb45070341
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