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Pentraxin-3 and Other Inflammatory Markers for an Infected Diabetic Foot Ulcer Diagnosis: A Prospective Study

Strategies have been researched and implemented to reduce the number of people with diabetic foot ulcers (DFUs). One problem is the accurate assessment of DFU severity, which is the main factor in resource allocation and treatment choice. The primary objective of this study was to assess pentraxin-3...

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Autores principales: Ardelean, Andrei, Balta, Diana-Federica, Neamtu, Carmen, Neamtu, Adriana Andreea, Rosu, Mihai, Pilat, Luminita, Moldovan, Silviu, Tarta, Cristi, Totolici, Bogdan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10377911/
https://www.ncbi.nlm.nih.gov/pubmed/37510110
http://dx.doi.org/10.3390/diagnostics13142366
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author Ardelean, Andrei
Balta, Diana-Federica
Neamtu, Carmen
Neamtu, Adriana Andreea
Rosu, Mihai
Pilat, Luminita
Moldovan, Silviu
Tarta, Cristi
Totolici, Bogdan
author_facet Ardelean, Andrei
Balta, Diana-Federica
Neamtu, Carmen
Neamtu, Adriana Andreea
Rosu, Mihai
Pilat, Luminita
Moldovan, Silviu
Tarta, Cristi
Totolici, Bogdan
author_sort Ardelean, Andrei
collection PubMed
description Strategies have been researched and implemented to reduce the number of people with diabetic foot ulcers (DFUs). One problem is the accurate assessment of DFU severity, which is the main factor in resource allocation and treatment choice. The primary objective of this study was to assess pentraxin-3 as a biomarker of an infected DFU (IDFU), the limb amputation level prognosis, and patient survival. The secondary objectives were to evaluate and compare other markers, including white blood cells (WBCs), C-reactive protein (CRP), the erythrocyte sedimentation rate (ESR), and procalcitonin (PCT), for identifying IDFUs. Over a period of two years, 145 patients were followed; 131 of these were analyzed for this study. Pentraxin-3 was found to be a good predictor of death (p = 0.047). A comparison between IDFUs and DFUs revealed the following differences: PCT had the highest AUROC of 0.91, sensitivity of 93.7, and specificity of 83.3%. CRP had a cutoff value of 226 mg/L, an AUROC of 0.89, a sensitivity of 95.5%, and a specificity of 83.3%. Fibrinogen had an AUROC of 0.87 at a cutoff value of 5.29 g/L, with a good sensitivity and specificity of 85% and 87%, respectively. ESR had a cutoff value of 46 mm/h, an AUROC of 85%, a sensitivity of 83.7%, and a specificity of 83.3%. Pentraxin-3 showed promising results in predicting IDFUs and DFUs, and it served as a marker for the risk of death in IDFU patients during the 6 month follow-up. Other markers, including CRP, PCT, ESR, and fibrinogen, were more effective in differentiating between IDFUs and DFUs.
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spelling pubmed-103779112023-07-29 Pentraxin-3 and Other Inflammatory Markers for an Infected Diabetic Foot Ulcer Diagnosis: A Prospective Study Ardelean, Andrei Balta, Diana-Federica Neamtu, Carmen Neamtu, Adriana Andreea Rosu, Mihai Pilat, Luminita Moldovan, Silviu Tarta, Cristi Totolici, Bogdan Diagnostics (Basel) Article Strategies have been researched and implemented to reduce the number of people with diabetic foot ulcers (DFUs). One problem is the accurate assessment of DFU severity, which is the main factor in resource allocation and treatment choice. The primary objective of this study was to assess pentraxin-3 as a biomarker of an infected DFU (IDFU), the limb amputation level prognosis, and patient survival. The secondary objectives were to evaluate and compare other markers, including white blood cells (WBCs), C-reactive protein (CRP), the erythrocyte sedimentation rate (ESR), and procalcitonin (PCT), for identifying IDFUs. Over a period of two years, 145 patients were followed; 131 of these were analyzed for this study. Pentraxin-3 was found to be a good predictor of death (p = 0.047). A comparison between IDFUs and DFUs revealed the following differences: PCT had the highest AUROC of 0.91, sensitivity of 93.7, and specificity of 83.3%. CRP had a cutoff value of 226 mg/L, an AUROC of 0.89, a sensitivity of 95.5%, and a specificity of 83.3%. Fibrinogen had an AUROC of 0.87 at a cutoff value of 5.29 g/L, with a good sensitivity and specificity of 85% and 87%, respectively. ESR had a cutoff value of 46 mm/h, an AUROC of 85%, a sensitivity of 83.7%, and a specificity of 83.3%. Pentraxin-3 showed promising results in predicting IDFUs and DFUs, and it served as a marker for the risk of death in IDFU patients during the 6 month follow-up. Other markers, including CRP, PCT, ESR, and fibrinogen, were more effective in differentiating between IDFUs and DFUs. MDPI 2023-07-13 /pmc/articles/PMC10377911/ /pubmed/37510110 http://dx.doi.org/10.3390/diagnostics13142366 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Ardelean, Andrei
Balta, Diana-Federica
Neamtu, Carmen
Neamtu, Adriana Andreea
Rosu, Mihai
Pilat, Luminita
Moldovan, Silviu
Tarta, Cristi
Totolici, Bogdan
Pentraxin-3 and Other Inflammatory Markers for an Infected Diabetic Foot Ulcer Diagnosis: A Prospective Study
title Pentraxin-3 and Other Inflammatory Markers for an Infected Diabetic Foot Ulcer Diagnosis: A Prospective Study
title_full Pentraxin-3 and Other Inflammatory Markers for an Infected Diabetic Foot Ulcer Diagnosis: A Prospective Study
title_fullStr Pentraxin-3 and Other Inflammatory Markers for an Infected Diabetic Foot Ulcer Diagnosis: A Prospective Study
title_full_unstemmed Pentraxin-3 and Other Inflammatory Markers for an Infected Diabetic Foot Ulcer Diagnosis: A Prospective Study
title_short Pentraxin-3 and Other Inflammatory Markers for an Infected Diabetic Foot Ulcer Diagnosis: A Prospective Study
title_sort pentraxin-3 and other inflammatory markers for an infected diabetic foot ulcer diagnosis: a prospective study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10377911/
https://www.ncbi.nlm.nih.gov/pubmed/37510110
http://dx.doi.org/10.3390/diagnostics13142366
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