Loss of PARP7 Increases Type I Interferon Signaling in EO771 Breast Cancer Cells and Prevents Mammary Tumor Growth by Increasing Antitumor Immunity

SIMPLE SUMMARY: Cancer development depends on interactions between the tumor microenvironment and the immune system. PARP7 negatively regulates the type I interferon pathway, ultimately preventing immune cells from detecting and eliminating cancer cells. Recently, inhibition of PARP7 activity has be...

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Detalles Bibliográficos
Autores principales: Rasmussen, Marit, Alvik, Karoline, Kannen, Vinicius, Olafsen, Ninni E., Erlingsson, Linnea A. M., Grimaldi, Giulia, Takaoka, Akinori, Grant, Denis M., Matthews, Jason
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10377955/
https://www.ncbi.nlm.nih.gov/pubmed/37509350
http://dx.doi.org/10.3390/cancers15143689

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