Mild and efficient synthesis of benzothiazolopyrimidine derivatives via CuAAC/ring cleavage/cyclization reaction

An operationally mild and efficient synthesis of benzothiazolopyrimidine is achieved by a three-component reaction of 2-aminebenzo[d]thiazoles, sulfonyl azides and terminal ynones. This cascade process involved a CuAAC/ring cleavage/cyclization reaction. Particularly, most of the benzothiazolopyrimi...

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Autores principales: Yang, Weiguang, Luo, Danyang, Li, Guanrong, Hu, Weigao, Zheng, Jia, Chen, Lanmei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2023
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10377972/
https://www.ncbi.nlm.nih.gov/pubmed/37520094
http://dx.doi.org/10.1039/d3ra04082h
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author Yang, Weiguang
Luo, Danyang
Li, Guanrong
Hu, Weigao
Zheng, Jia
Chen, Lanmei
author_facet Yang, Weiguang
Luo, Danyang
Li, Guanrong
Hu, Weigao
Zheng, Jia
Chen, Lanmei
author_sort Yang, Weiguang
collection PubMed
description An operationally mild and efficient synthesis of benzothiazolopyrimidine is achieved by a three-component reaction of 2-aminebenzo[d]thiazoles, sulfonyl azides and terminal ynones. This cascade process involved a CuAAC/ring cleavage/cyclization reaction. Particularly, most of the benzothiazolopyrimidine derivatives could be isolated by filtration without further purification.
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spelling pubmed-103779722023-07-29 Mild and efficient synthesis of benzothiazolopyrimidine derivatives via CuAAC/ring cleavage/cyclization reaction Yang, Weiguang Luo, Danyang Li, Guanrong Hu, Weigao Zheng, Jia Chen, Lanmei RSC Adv Chemistry An operationally mild and efficient synthesis of benzothiazolopyrimidine is achieved by a three-component reaction of 2-aminebenzo[d]thiazoles, sulfonyl azides and terminal ynones. This cascade process involved a CuAAC/ring cleavage/cyclization reaction. Particularly, most of the benzothiazolopyrimidine derivatives could be isolated by filtration without further purification. The Royal Society of Chemistry 2023-07-28 /pmc/articles/PMC10377972/ /pubmed/37520094 http://dx.doi.org/10.1039/d3ra04082h Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Yang, Weiguang
Luo, Danyang
Li, Guanrong
Hu, Weigao
Zheng, Jia
Chen, Lanmei
Mild and efficient synthesis of benzothiazolopyrimidine derivatives via CuAAC/ring cleavage/cyclization reaction
title Mild and efficient synthesis of benzothiazolopyrimidine derivatives via CuAAC/ring cleavage/cyclization reaction
title_full Mild and efficient synthesis of benzothiazolopyrimidine derivatives via CuAAC/ring cleavage/cyclization reaction
title_fullStr Mild and efficient synthesis of benzothiazolopyrimidine derivatives via CuAAC/ring cleavage/cyclization reaction
title_full_unstemmed Mild and efficient synthesis of benzothiazolopyrimidine derivatives via CuAAC/ring cleavage/cyclization reaction
title_short Mild and efficient synthesis of benzothiazolopyrimidine derivatives via CuAAC/ring cleavage/cyclization reaction
title_sort mild and efficient synthesis of benzothiazolopyrimidine derivatives via cuaac/ring cleavage/cyclization reaction
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10377972/
https://www.ncbi.nlm.nih.gov/pubmed/37520094
http://dx.doi.org/10.1039/d3ra04082h
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