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Prenatal detection of major congenital malformations in a cohort of 19 367 Danish fetuses with a complete follow‐up six months after birth
INTRODUCTION: To investigate the performance of the second‐trimester ultrasound scan regarding ultrasound‐detectable congenital malformations in a Danish region. The study sample was population‐based, with 6 months of postnatal follow‐up. Hospital records and autopsy reports were reviewed in each ca...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10378016/ https://www.ncbi.nlm.nih.gov/pubmed/37270668 http://dx.doi.org/10.1111/aogs.14582 |
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author | Hjort‐Pedersen, Karina Olesen, Annette Wind Garne, Ester Sperling, Lene |
author_facet | Hjort‐Pedersen, Karina Olesen, Annette Wind Garne, Ester Sperling, Lene |
author_sort | Hjort‐Pedersen, Karina |
collection | PubMed |
description | INTRODUCTION: To investigate the performance of the second‐trimester ultrasound scan regarding ultrasound‐detectable congenital malformations in a Danish region. The study sample was population‐based, with 6 months of postnatal follow‐up. Hospital records and autopsy reports were reviewed in each case to validate the prenatal ultrasound diagnosis. MATERIAL AND METHODS: This population‐based cohort study included all fetuses (n = 19.367) alive at the second‐trimester scan in four hospitals in a Danish region. The final diagnosis of the malformations was based on hospital records during the 6‐month postnatal follow‐up. In case of termination or stillbirth, the result from the autopsy report was used to validate the prenatal ultrasound diagnosis. RESULTS: The detection rate of congenital malformations in the prenatal screening program was 69%, where 18% was detected on the first‐trimester scan and 51% on the second‐trimester scan. Another 8% was detected in the third trimester. Specificity was 99.9%. The positive predictive value of the screening program was 94.5%, and the negative predictive value was 99.5%. The overall prevalence of malformations was 16.8 per 1000 fetuses, most frequently in the heart and the urinary tract. CONCLUSIONS: This study shows that the national screening program for congenital malformations can detect many severe malformations and is an effective screening test for malformations. |
format | Online Article Text |
id | pubmed-10378016 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-103780162023-07-29 Prenatal detection of major congenital malformations in a cohort of 19 367 Danish fetuses with a complete follow‐up six months after birth Hjort‐Pedersen, Karina Olesen, Annette Wind Garne, Ester Sperling, Lene Acta Obstet Gynecol Scand Fetal Medicine INTRODUCTION: To investigate the performance of the second‐trimester ultrasound scan regarding ultrasound‐detectable congenital malformations in a Danish region. The study sample was population‐based, with 6 months of postnatal follow‐up. Hospital records and autopsy reports were reviewed in each case to validate the prenatal ultrasound diagnosis. MATERIAL AND METHODS: This population‐based cohort study included all fetuses (n = 19.367) alive at the second‐trimester scan in four hospitals in a Danish region. The final diagnosis of the malformations was based on hospital records during the 6‐month postnatal follow‐up. In case of termination or stillbirth, the result from the autopsy report was used to validate the prenatal ultrasound diagnosis. RESULTS: The detection rate of congenital malformations in the prenatal screening program was 69%, where 18% was detected on the first‐trimester scan and 51% on the second‐trimester scan. Another 8% was detected in the third trimester. Specificity was 99.9%. The positive predictive value of the screening program was 94.5%, and the negative predictive value was 99.5%. The overall prevalence of malformations was 16.8 per 1000 fetuses, most frequently in the heart and the urinary tract. CONCLUSIONS: This study shows that the national screening program for congenital malformations can detect many severe malformations and is an effective screening test for malformations. John Wiley and Sons Inc. 2023-06-03 /pmc/articles/PMC10378016/ /pubmed/37270668 http://dx.doi.org/10.1111/aogs.14582 Text en © 2023 The Authors. Acta Obstetricia et Gynecologica Scandinavica published by John Wiley & Sons Ltd on behalf of Nordic Federation of Societies of Obstetrics and Gynecology (NFOG). https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
spellingShingle | Fetal Medicine Hjort‐Pedersen, Karina Olesen, Annette Wind Garne, Ester Sperling, Lene Prenatal detection of major congenital malformations in a cohort of 19 367 Danish fetuses with a complete follow‐up six months after birth |
title | Prenatal detection of major congenital malformations in a cohort of 19 367 Danish fetuses with a complete follow‐up six months after birth |
title_full | Prenatal detection of major congenital malformations in a cohort of 19 367 Danish fetuses with a complete follow‐up six months after birth |
title_fullStr | Prenatal detection of major congenital malformations in a cohort of 19 367 Danish fetuses with a complete follow‐up six months after birth |
title_full_unstemmed | Prenatal detection of major congenital malformations in a cohort of 19 367 Danish fetuses with a complete follow‐up six months after birth |
title_short | Prenatal detection of major congenital malformations in a cohort of 19 367 Danish fetuses with a complete follow‐up six months after birth |
title_sort | prenatal detection of major congenital malformations in a cohort of 19 367 danish fetuses with a complete follow‐up six months after birth |
topic | Fetal Medicine |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10378016/ https://www.ncbi.nlm.nih.gov/pubmed/37270668 http://dx.doi.org/10.1111/aogs.14582 |
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