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Probing Intrinsic Neural Timescales in EEG with an Information-Theory Inspired Approach: Permutation Entropy Time Delay Estimation (PE-TD)

Time delays are a signature of many physical systems, including the brain, and considerably shape their dynamics; moreover, they play a key role in consciousness, as postulated by the temporo-spatial theory of consciousness (TTC). However, they are often not known a priori and need to be estimated f...

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Autores principales: Buccellato, Andrea, Çatal, Yasir, Bisiacchi, Patrizia, Zang, Di, Zilio, Federico, Wang, Zhe, Qi, Zengxin, Zheng, Ruizhe, Xu, Zeyu, Wu, Xuehai, Del Felice, Alessandra, Mao, Ying, Northoff, Georg
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10378026/
https://www.ncbi.nlm.nih.gov/pubmed/37510033
http://dx.doi.org/10.3390/e25071086
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author Buccellato, Andrea
Çatal, Yasir
Bisiacchi, Patrizia
Zang, Di
Zilio, Federico
Wang, Zhe
Qi, Zengxin
Zheng, Ruizhe
Xu, Zeyu
Wu, Xuehai
Del Felice, Alessandra
Mao, Ying
Northoff, Georg
author_facet Buccellato, Andrea
Çatal, Yasir
Bisiacchi, Patrizia
Zang, Di
Zilio, Federico
Wang, Zhe
Qi, Zengxin
Zheng, Ruizhe
Xu, Zeyu
Wu, Xuehai
Del Felice, Alessandra
Mao, Ying
Northoff, Georg
author_sort Buccellato, Andrea
collection PubMed
description Time delays are a signature of many physical systems, including the brain, and considerably shape their dynamics; moreover, they play a key role in consciousness, as postulated by the temporo-spatial theory of consciousness (TTC). However, they are often not known a priori and need to be estimated from time series. In this study, we propose the use of permutation entropy (PE) to estimate time delays from neural time series as a more robust alternative to the widely used autocorrelation window (ACW). In the first part, we demonstrate the validity of this approach on synthetic neural data, and we show its resistance to regimes of nonstationarity in time series. Mirroring yet another example of comparable behavior between different nonlinear systems, permutation entropy–time delay estimation (PE-TD) is also able to measure intrinsic neural timescales (INTs) (temporal windows of neural activity at rest) from hd-EEG human data; additionally, this replication extends to the abnormal prolongation of INT values in disorders of consciousness (DoCs). Surprisingly, the correlation between ACW-0 and PE-TD decreases in a state-dependent manner when consciousness is lost, hinting at potential different regimes of nonstationarity and nonlinearity in conscious/unconscious states, consistent with many current theoretical frameworks on consciousness. In summary, we demonstrate the validity of PE-TD as a tool to extract relevant time scales from neural data; furthermore, given the divergence between ACW and PE-TD specific to DoC subjects, we hint at its potential use for the characterization of conscious states.
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spelling pubmed-103780262023-07-29 Probing Intrinsic Neural Timescales in EEG with an Information-Theory Inspired Approach: Permutation Entropy Time Delay Estimation (PE-TD) Buccellato, Andrea Çatal, Yasir Bisiacchi, Patrizia Zang, Di Zilio, Federico Wang, Zhe Qi, Zengxin Zheng, Ruizhe Xu, Zeyu Wu, Xuehai Del Felice, Alessandra Mao, Ying Northoff, Georg Entropy (Basel) Article Time delays are a signature of many physical systems, including the brain, and considerably shape their dynamics; moreover, they play a key role in consciousness, as postulated by the temporo-spatial theory of consciousness (TTC). However, they are often not known a priori and need to be estimated from time series. In this study, we propose the use of permutation entropy (PE) to estimate time delays from neural time series as a more robust alternative to the widely used autocorrelation window (ACW). In the first part, we demonstrate the validity of this approach on synthetic neural data, and we show its resistance to regimes of nonstationarity in time series. Mirroring yet another example of comparable behavior between different nonlinear systems, permutation entropy–time delay estimation (PE-TD) is also able to measure intrinsic neural timescales (INTs) (temporal windows of neural activity at rest) from hd-EEG human data; additionally, this replication extends to the abnormal prolongation of INT values in disorders of consciousness (DoCs). Surprisingly, the correlation between ACW-0 and PE-TD decreases in a state-dependent manner when consciousness is lost, hinting at potential different regimes of nonstationarity and nonlinearity in conscious/unconscious states, consistent with many current theoretical frameworks on consciousness. In summary, we demonstrate the validity of PE-TD as a tool to extract relevant time scales from neural data; furthermore, given the divergence between ACW and PE-TD specific to DoC subjects, we hint at its potential use for the characterization of conscious states. MDPI 2023-07-19 /pmc/articles/PMC10378026/ /pubmed/37510033 http://dx.doi.org/10.3390/e25071086 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Buccellato, Andrea
Çatal, Yasir
Bisiacchi, Patrizia
Zang, Di
Zilio, Federico
Wang, Zhe
Qi, Zengxin
Zheng, Ruizhe
Xu, Zeyu
Wu, Xuehai
Del Felice, Alessandra
Mao, Ying
Northoff, Georg
Probing Intrinsic Neural Timescales in EEG with an Information-Theory Inspired Approach: Permutation Entropy Time Delay Estimation (PE-TD)
title Probing Intrinsic Neural Timescales in EEG with an Information-Theory Inspired Approach: Permutation Entropy Time Delay Estimation (PE-TD)
title_full Probing Intrinsic Neural Timescales in EEG with an Information-Theory Inspired Approach: Permutation Entropy Time Delay Estimation (PE-TD)
title_fullStr Probing Intrinsic Neural Timescales in EEG with an Information-Theory Inspired Approach: Permutation Entropy Time Delay Estimation (PE-TD)
title_full_unstemmed Probing Intrinsic Neural Timescales in EEG with an Information-Theory Inspired Approach: Permutation Entropy Time Delay Estimation (PE-TD)
title_short Probing Intrinsic Neural Timescales in EEG with an Information-Theory Inspired Approach: Permutation Entropy Time Delay Estimation (PE-TD)
title_sort probing intrinsic neural timescales in eeg with an information-theory inspired approach: permutation entropy time delay estimation (pe-td)
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10378026/
https://www.ncbi.nlm.nih.gov/pubmed/37510033
http://dx.doi.org/10.3390/e25071086
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