EML4-ALK Gene Mutation Detected with New NGS Lung Cancer Panel CDx Using Sputum Cytology in a Case of Advanced NSCLC

The detection of driver gene mutations has become essential for lung cancer; however, insufficient sample sizes make gene panel tests difficult to use. We previously reported that the lung cancer compact panel TM (LCCP) could detect EGFR and MET gene mutations with sputum cytology. To date, the dete...

Descripción completa

Detalles Bibliográficos
Autores principales: Morikawa, Kei, Kinoshita, Kohei, Matsuzawa, Shin, Kida, Hirotaka, Handa, Hiroshi, Inoue, Takeo, Nakamura, Seiji, Sato, Yoshiharu, Mineshita, Masamichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Interesting Images
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10378045/
https://www.ncbi.nlm.nih.gov/pubmed/37510070
http://dx.doi.org/10.3390/diagnostics13142327
Descripción
Sumario:The detection of driver gene mutations has become essential for lung cancer; however, insufficient sample sizes make gene panel tests difficult to use. We previously reported that the lung cancer compact panel TM (LCCP) could detect EGFR and MET gene mutations with sputum cytology. To date, the detection of gene mutation using RNA from sputum samples is considered practically difficult. We report a case in which the EML4-ALK fusion gene was successfully detected from a sputum sample using the LCCP that was just released in Japan as a new next-generation sequencing lung cancer panel, CDx.

Ejemplares similares