Questions about Using the Induced Membrane Technique to Manage Cases of Congenital Tibial Pseudarthrosis

The induced membrane technique is an innovative approach for repairing critical bone defects and has been applied recently in patients with congenital pseudarthrosis of the tibia (CPT). CPT is frequently associated with neurofibromatosis type 1 (NF1). Here, we briefly describe the clinical results o...

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Detalles Bibliográficos
Autores principales: Klein, Céline, Gindraux, Florelle, Masquelet, Alain-Charles, Mentaverri, Romuald, Gouron, Richard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Editorial
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10378057/
https://www.ncbi.nlm.nih.gov/pubmed/37508581
http://dx.doi.org/10.3390/cells12141918
Descripción
Sumario:The induced membrane technique is an innovative approach for repairing critical bone defects and has been applied recently in patients with congenital pseudarthrosis of the tibia (CPT). CPT is frequently associated with neurofibromatosis type 1 (NF1). Here, we briefly describe the clinical results of the induced membrane technique in NF1-deficient patients with CPT and in an animal model of CPT. Furthermore, we discuss the hypotheses used to explain inconsistent outcomes for the induced membrane technique in CPT–especially when associated with NF1.

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