Cargando…

Comprehensive Immune Profiling Unveils a Subset of Leiomyosarcoma with “Hot” Tumor Immune Microenvironment

SIMPLE SUMMARY: Leiomyosarcoma (LMS) is thought to be an immune cold tumor that generally does not respond to immune checkpoint inhibitors (ICIs). To date, there is no validated immune biomarker used in LMS patients. The tertiary lymphoid structure (TLS) is the only potential predictive biomarker, b...

Descripción completa

Detalles Bibliográficos
Autores principales:	Feng, Xiaolan, Tonon, Laurie, Li, Haocheng, Darbo, Elodie, Pleasance, Erin, Macagno, Nicolas, Dufresne, Armelle, Brahmi, Mehdi, Bollard, Julien, Ducimetière, Francoise, Karanian, Marie, Meurgey, Alexandra, Pérot, Gaëlle, Valentin, Thibaud, Chibon, Frédéric, Blay, Jean-Yves
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10378143/ https://www.ncbi.nlm.nih.gov/pubmed/37509366 http://dx.doi.org/10.3390/cancers15143705

Ejemplares similares

Refining Prognosis in Localized Gastrointestinal Stromal Tumor: Clinical Significance of Phosphatase and Tensin Homolog Low Expression and Gene Loss
por: Feng, Xiaolan, et al.
Publicado: (2022)

Expanding the molecular spectrum of tenosynovial giant cell tumors
por: Gauduchon, Thibault, et al.
Publicado: (2022)

Molecular Classification of Endometrial Stromal Sarcomas Using RNA Sequencing Defines Nosological and Prognostic Subgroups with Different Natural History
por: Brahmi, Mehdi, et al.
Publicado: (2020)

Specific immune landscapes and immune checkpoint expressions in histotypes and molecular subtypes of sarcoma
por: Dufresne, A., et al.
Publicado: (2020)

Efficacy and Safety of Adjuvant Radiotherapy in Re-excised Soft-tissue Sarcoma After Unplanned Resection
por: Allignet, Benoît, et al.
Publicado: (2023)

Distinct Cellular Origins and Differentiation Process Account for Distinct Oncogenic and Clinical Behaviors of Leiomyosarcomas
por: Darbo, Elodie, et al.
Publicado: (2023)

Long term term follow-up of tyrosine kinase inhibitors treatments in inoperable or relapsing diffuse type tenosynovial giant cell tumors (dTGCT)
por: Brahmi, Mehdi, et al.
Publicado: (2020)

Analysis of the Peritumoral Tissue Unveils Cellular Changes Associated with a High Risk of Recurrence
por: Michot, Audrey, et al.
Publicado: (2023)

ATRX Alteration Contributes to Tumor Growth and Immune Escape in Pleomorphic Sarcomas
por: Darmusey, Lucie, et al.
Publicado: (2021)

Expression and role of TYRO3 and AXL as potential therapeutical targets in leiomyosarcoma
por: Dantas-Barbosa, Carmela, et al.
Publicado: (2017)

Immunotherapy for Soft Tissue Sarcomas: Anti-PD1/PDL1 and Beyond
por: Fazel, Mina, et al.
Publicado: (2023)

Recurrent DMD Deletions Highlight Specific Role of Dp71 Isoform in Soft-Tissue Sarcomas
por: Mauduit, Olivier, et al.
Publicado: (2019)

Very long‐term survivors among patients with metastatic soft tissue sarcoma
por: Carbonnaux, Mélodie, et al.
Publicado: (2019)

Impact of KIT exon 10 M541L allelic variant on the response to imatinib in aggressive fibromatosis: analysis of the desminib series by competitive allele specific Taqman PCR technology
por: Dufresne, Armelle, et al.
Publicado: (2014)

Novel Therapeutic Options for Solitary Fibrous Tumor: Antiangiogenic Therapy and Beyond
por: de Bernardi, Axel, et al.
Publicado: (2022)

Expression and prognostic significance of PDGF ligands and receptors across soft tissue sarcomas
por: Brahmi, M., et al.
Publicado: (2021)

Outcomes of patients with metastatic gastrointestinal stromal tumors (GIST) treated with multi-kinase inhibitors other than imatinib as first-line treatment
por: Boilève, Alice, et al.
Publicado: (2020)

Evolution of Patterns of Care and Outcomes in the Real-Life Setting for Patients with Metastatic GIST Treated in Three French Expert Centers over Three Decades
por: Toulmonde, Maud, et al.
Publicado: (2023)

KIT exon 10 variant (c.1621 A > C) single nucleotide polymorphism as predictor of GIST patient outcome
por: Brahmi, Mehdi, et al.
Publicado: (2015)

The Adaptive and Innate Immune Cell Landscape of Uterine Leiomyosarcomas
por: Manzoni, Marco, et al.
Publicado: (2020)

Natural history and treatment efficacy in an ambispective case series of NTRK-rearranged mesenchymal tumors
por: Dufresne, A., et al.
Publicado: (2023)

Trabectedin and its potential in the treatment of soft tissue sarcoma
por: Cassier, Philippe A, et al.
Publicado: (2008)

Germinal GLT8D1, GATAD2A and SLC25A39 mutations in a patient with a glomangiopericytal tumor and five different sarcomas over a 10-year period
por: Beddok, Arnaud, et al.
Publicado: (2021)

RCBTB1 Deletion Is Associated with Metastatic Outcome and Contributes to Docetaxel Resistance in Nontranslocation-Related Pleomorphic Sarcomas
por: Mauduit, Olivier, et al.
Publicado: (2019)

Author Correction: The Adaptive and Innate Immune Cell Landscape of Uterine Leiomyosarcomas
por: Manzoni, Marco, et al.
Publicado: (2021)

Unveiling the roles of autophagy in innate and adaptive immunity
por: Levine, Beth, et al.
Publicado: (2007)

Percutaneous Core Needle Biopsy Can Efficiently and Safely Diagnose Most Primary Bone Tumors
por: Crenn, Vincent, et al.
Publicado: (2021)

Therapeutic relevance of molecular screening program in patients with metastatic sarcoma: Analysis from the ProfiLER 01 trial
por: Arnaud-Coffin, Patrick, et al.
Publicado: (2020)

The immune landscape of chondrosarcoma reveals an immunosuppressive environment in the dedifferentiated subtypes and exposes CSFR1+ macrophages as a promising therapeutic target
por: Iseulys, Richert, et al.
Publicado: (2019)

Tetraploidization of Immortalized Myoblasts Induced by Cell Fusion Drives Myogenic Sarcoma Development with DMD Deletion
por: Merle, Candice, et al.
Publicado: (2020)

Recombinant erythropoietin for the anaemia of patients with advanced Gastrointestinal Stromal Tumours (GIST) receiving imatinib: an active agent only in non progressive patients
por: Duffaud, Florence, et al.
Publicado: (2012)

Unveiling the stealthy tactics: mycoplasma’s immune evasion strategies
por: Wang, Jingyun, et al.
Publicado: (2023)

Identification of a Recurrent STRN/ALK Fusion in Thyroid Carcinomas
por: Pérot, Gaëlle, et al.
Publicado: (2014)

Cell–cell fusion of mesenchymal cells with distinct differentiations triggers genomic and transcriptomic remodelling toward tumour aggressiveness
por: Delespaul, Lucile, et al.
Publicado: (2020)

Controlling Cytomegalovirus: Helping the Immune System Take the Lead
por: Hanley, Patrick J., et al.
Publicado: (2014)

Inhibition of Bcl-2 family members sensitises soft tissue leiomyosarcomas to chemotherapy
por: de Graaff, Marieke A, et al.
Publicado: (2016)

Unveiling Unexpected Immune Activities Induced by Your Pneumococcal Vaccine
por: Hurwitz, Julia L., et al.
Publicado: (2016)

Unveiling the Link Between Inflammation and Adaptive Immunity in Breast Cancer
por: Velazquez-Caldelas, Tadeo Enrique, et al.
Publicado: (2019)

Unveiling the contributions of immunization for progressing towards Universal Health Coverage
por: Ota, Martin O. C., et al.
Publicado: (2022)

Assessment of immunization data management practices in Cameroon: unveiling potential barriers to immunization data quality
por: Saidu, Yauba, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_c2b43duobvt84boso6k2lshk4f