Foxm1 haploinsufficiency drives clonal hematopoiesis and promotes a stress-related transition to hematologic malignancy in mice

Clonal hematopoiesis plays a critical role in the initiation and development of hematologic malignancies. In patients with del(5q) myelodysplastic syndrome (MDS), the transcription factor FOXM1 is frequently downregulated in CD34(+) cells. In this study, we demonstrated that Foxm1 haploinsufficiency...

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Detalles Bibliográficos
Autores principales: Yu, Chunjie, Sheng, Yue, Yu, Fang, Ni, Hongyu, Qiu, Alan, Huang, Yong, Qian, Zhijian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10378147/
https://www.ncbi.nlm.nih.gov/pubmed/37526082
http://dx.doi.org/10.1172/JCI163911

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