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Having it both ways: how STAT3 deficiency blocks graft-versus-host disease while preserving graft-versus-leukemia activity

Allogeneic hematopoietic cell transplantation can cure patients with high-risk leukemia through graft-versus-leukemia (GVL) effects, the process by which malignant leukemic cells are cleared by donor-derived immune cells from the graft. The problem of harnessing GVL effects while controlling inflamm...

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Detalles Bibliográficos
Autores principales:	Brandstadter, Joshua D., Outen, Riley, Maillard, Ivan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Clinical Investigation 2023
Materias:	Commentary
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10378150/ https://www.ncbi.nlm.nih.gov/pubmed/37526083 http://dx.doi.org/10.1172/JCI172251

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