Donor T cell STAT3 deficiency enables tissue PD-L1–dependent prevention of graft-versus-host disease while preserving graft-versus-leukemia activity

STAT3 deficiency (STAT3(–/–)) in donor T cells prevents graft-versus-host disease (GVHD), but the impact on graft-versus-leukemia (GVL) activity and mechanisms of GVHD prevention remains unclear. Here, using murine models of GVHD, we show that STAT3(–/–) donor T cells induced only mild reversible ac...

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Detalles Bibliográficos
Autores principales: Li, Qinjian, Wang, Xiaoqi, Song, Qingxiao, Yang, Shijie, Wu, Xiwei, Yang, Dongyun, Marié, Isabelle J., Qin, Hanjun, Zheng, Moqian, Nasri, Ubaydah, Kong, Xiaohui, Wang, Bixin, Lizhar, Elizabeth, Cassady, Kaniel, Tompkins, Josh, Levy, David, Martin, Paul J., Zhang, Xi, Zeng, Defu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10378157/
https://www.ncbi.nlm.nih.gov/pubmed/37526084
http://dx.doi.org/10.1172/JCI165723

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