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High CCL2 Levels Detected in CSF of Patients with Pediatric Pseudotumor Cerebri Syndrome

Pseudotumor cerebri (PTC) is a disorder characterized by increased intracranial pressure in the absence of a structural lesion or other identifiable cause. Cytokines, which are involved in the regulation of immune responses and inflammation, have been implicated in the pathogenesis of PTC. In a pros...

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Autores principales: Genizi, Jacob, Berger, Lotan, Mahajnah, Muhammad, Shlonsky, Yulia, Golan-Shany, Orit, Romem, Azriel, Halevy, Ayelet, Nathan, Keren, Sharkia, Rajech, Zalan, Abdelnaser, Kessel, Aharon, Cohen, Rony
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10378220/
https://www.ncbi.nlm.nih.gov/pubmed/37508619
http://dx.doi.org/10.3390/children10071122
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author Genizi, Jacob
Berger, Lotan
Mahajnah, Muhammad
Shlonsky, Yulia
Golan-Shany, Orit
Romem, Azriel
Halevy, Ayelet
Nathan, Keren
Sharkia, Rajech
Zalan, Abdelnaser
Kessel, Aharon
Cohen, Rony
author_facet Genizi, Jacob
Berger, Lotan
Mahajnah, Muhammad
Shlonsky, Yulia
Golan-Shany, Orit
Romem, Azriel
Halevy, Ayelet
Nathan, Keren
Sharkia, Rajech
Zalan, Abdelnaser
Kessel, Aharon
Cohen, Rony
author_sort Genizi, Jacob
collection PubMed
description Pseudotumor cerebri (PTC) is a disorder characterized by increased intracranial pressure in the absence of a structural lesion or other identifiable cause. Cytokines, which are involved in the regulation of immune responses and inflammation, have been implicated in the pathogenesis of PTC. In a prospective, cross-sectional study at three centers in Israel, we analyzed cerebrospinal fluid (CSF) samples from 60 children aged 0.5–18 years, including 43 children with a definitive diagnosis of PTC and a control group of 17 children. Levels of IL-4, IL-10, IL-17, CCL2, CCL7, CCL8, CCL13, BDNF, and IFN-γ were measured using ELISA kits. Levels of CCL2 were significantly higher in the PTC group compared to the control group (p < 0.05), with no other significant differences in the measured cytokines between the two groups. The groups did not differ significantly in clinical presentation, imaging, treatment, or ophthalmic findings. Our findings provide preliminary evidence that CCL2 may be involved in the pathogenesis of PTC and may serve a potential target for therapy in PTC.
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spelling pubmed-103782202023-07-29 High CCL2 Levels Detected in CSF of Patients with Pediatric Pseudotumor Cerebri Syndrome Genizi, Jacob Berger, Lotan Mahajnah, Muhammad Shlonsky, Yulia Golan-Shany, Orit Romem, Azriel Halevy, Ayelet Nathan, Keren Sharkia, Rajech Zalan, Abdelnaser Kessel, Aharon Cohen, Rony Children (Basel) Communication Pseudotumor cerebri (PTC) is a disorder characterized by increased intracranial pressure in the absence of a structural lesion or other identifiable cause. Cytokines, which are involved in the regulation of immune responses and inflammation, have been implicated in the pathogenesis of PTC. In a prospective, cross-sectional study at three centers in Israel, we analyzed cerebrospinal fluid (CSF) samples from 60 children aged 0.5–18 years, including 43 children with a definitive diagnosis of PTC and a control group of 17 children. Levels of IL-4, IL-10, IL-17, CCL2, CCL7, CCL8, CCL13, BDNF, and IFN-γ were measured using ELISA kits. Levels of CCL2 were significantly higher in the PTC group compared to the control group (p < 0.05), with no other significant differences in the measured cytokines between the two groups. The groups did not differ significantly in clinical presentation, imaging, treatment, or ophthalmic findings. Our findings provide preliminary evidence that CCL2 may be involved in the pathogenesis of PTC and may serve a potential target for therapy in PTC. MDPI 2023-06-28 /pmc/articles/PMC10378220/ /pubmed/37508619 http://dx.doi.org/10.3390/children10071122 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Genizi, Jacob
Berger, Lotan
Mahajnah, Muhammad
Shlonsky, Yulia
Golan-Shany, Orit
Romem, Azriel
Halevy, Ayelet
Nathan, Keren
Sharkia, Rajech
Zalan, Abdelnaser
Kessel, Aharon
Cohen, Rony
High CCL2 Levels Detected in CSF of Patients with Pediatric Pseudotumor Cerebri Syndrome
title High CCL2 Levels Detected in CSF of Patients with Pediatric Pseudotumor Cerebri Syndrome
title_full High CCL2 Levels Detected in CSF of Patients with Pediatric Pseudotumor Cerebri Syndrome
title_fullStr High CCL2 Levels Detected in CSF of Patients with Pediatric Pseudotumor Cerebri Syndrome
title_full_unstemmed High CCL2 Levels Detected in CSF of Patients with Pediatric Pseudotumor Cerebri Syndrome
title_short High CCL2 Levels Detected in CSF of Patients with Pediatric Pseudotumor Cerebri Syndrome
title_sort high ccl2 levels detected in csf of patients with pediatric pseudotumor cerebri syndrome
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10378220/
https://www.ncbi.nlm.nih.gov/pubmed/37508619
http://dx.doi.org/10.3390/children10071122
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