Roles of Extracellular Vesicles on the Progression and Metastasis of Hepatocellular Carcinoma

Liver cancer is a global health challenge as it is the third leading cause of cancer death worldwide. Hepatocellular carcinoma (HCC) is the most common type of liver cancer and is often found in liver cells, where it is associated with high morbidity and mortality rates. Recent studies have shown th...

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Autores principales: Seay, Turner W., Suo, Zucai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10378249/
https://www.ncbi.nlm.nih.gov/pubmed/37508544
http://dx.doi.org/10.3390/cells12141879
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author Seay, Turner W.
Suo, Zucai
author_facet Seay, Turner W.
Suo, Zucai
author_sort Seay, Turner W.
collection PubMed
description Liver cancer is a global health challenge as it is the third leading cause of cancer death worldwide. Hepatocellular carcinoma (HCC) is the most common type of liver cancer and is often found in liver cells, where it is associated with high morbidity and mortality rates. Recent studies have shown that extracellular vesicles (EVs) secreted by HCC cells play a critical role in HCC progression and metastasis. EVs contain proteins, nucleic acids, lipids, and metabolites as cargos. EVs derived from HCC cells can transfer oncogenic factors to surrounding cells leading to increased tumor growth, cell invasion, and angiogenesis. In this review, we summarize the roles that EVs play and the specific effects of their cargos on HCC progression and metastasis and identify potential therapeutic targets for HCC treatment.
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spelling pubmed-103782492023-07-29 Roles of Extracellular Vesicles on the Progression and Metastasis of Hepatocellular Carcinoma Seay, Turner W. Suo, Zucai Cells Review Liver cancer is a global health challenge as it is the third leading cause of cancer death worldwide. Hepatocellular carcinoma (HCC) is the most common type of liver cancer and is often found in liver cells, where it is associated with high morbidity and mortality rates. Recent studies have shown that extracellular vesicles (EVs) secreted by HCC cells play a critical role in HCC progression and metastasis. EVs contain proteins, nucleic acids, lipids, and metabolites as cargos. EVs derived from HCC cells can transfer oncogenic factors to surrounding cells leading to increased tumor growth, cell invasion, and angiogenesis. In this review, we summarize the roles that EVs play and the specific effects of their cargos on HCC progression and metastasis and identify potential therapeutic targets for HCC treatment. MDPI 2023-07-18 /pmc/articles/PMC10378249/ /pubmed/37508544 http://dx.doi.org/10.3390/cells12141879 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Seay, Turner W.
Suo, Zucai
Roles of Extracellular Vesicles on the Progression and Metastasis of Hepatocellular Carcinoma
title Roles of Extracellular Vesicles on the Progression and Metastasis of Hepatocellular Carcinoma
title_full Roles of Extracellular Vesicles on the Progression and Metastasis of Hepatocellular Carcinoma
title_fullStr Roles of Extracellular Vesicles on the Progression and Metastasis of Hepatocellular Carcinoma
title_full_unstemmed Roles of Extracellular Vesicles on the Progression and Metastasis of Hepatocellular Carcinoma
title_short Roles of Extracellular Vesicles on the Progression and Metastasis of Hepatocellular Carcinoma
title_sort roles of extracellular vesicles on the progression and metastasis of hepatocellular carcinoma
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10378249/
https://www.ncbi.nlm.nih.gov/pubmed/37508544
http://dx.doi.org/10.3390/cells12141879
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