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Human Milk Feeding Is Associated with Decreased Incidence of Moderate-Severe Bronchopulmonary Dysplasia in Extremely Preterm Infants
Background: An increased rate of bronchopulmonary dysplasia (BPD) is reported in extremely preterm infants. A potential role of human milk feeding in protecting against this condition has been suggested. Methods: A retrospective descriptive study was conducted based on data about morbidity in the po...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10378323/ https://www.ncbi.nlm.nih.gov/pubmed/37508764 http://dx.doi.org/10.3390/children10071267 |
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author | Verd, Sergio Porta, Roser Ginovart, Gemma Avila-Alvarez, Alejandro García-Muñoz Rodrigo, Fermín Izquierdo Renau, Montserrat Ventura, Paula Sol |
author_facet | Verd, Sergio Porta, Roser Ginovart, Gemma Avila-Alvarez, Alejandro García-Muñoz Rodrigo, Fermín Izquierdo Renau, Montserrat Ventura, Paula Sol |
author_sort | Verd, Sergio |
collection | PubMed |
description | Background: An increased rate of bronchopulmonary dysplasia (BPD) is reported in extremely preterm infants. A potential role of human milk feeding in protecting against this condition has been suggested. Methods: A retrospective descriptive study was conducted based on data about morbidity in the population of infants born between 22+0 and 26+6 weeks of gestation, included in the Spanish network SEN1500 during the period 2004–2019 and discharged alive. The primary outcome was moderate-severe BPD. Associated conditions were studied, including human milk feeding at discharge. The temporal trends of BPD and human milk feeding rates at discharge were also studied. Results: In the study population of 4341 infants, the rate of moderate-severe BPD was 43.7% and it increased to >50% in the last three years. The factors significantly associated with a higher risk of moderate-severe BPD were birth weight, male sex, high-frequency oscillatory ventilation, duration of invasive mechanical ventilation, inhaled nitric oxide, patent ductus arteriosus, and late-onset sepsis. Exclusive human milk feeding and any amount of human milk at discharge were associated with a lower incidence of moderate-severe BPD (OR 0.752, 95% CI 0.629–0.901 and OR 0.714, 95% CI 0.602–0.847, respectively). During the study period, the proportion of infants with moderate-severe BPD fed any amount of human milk at discharge increased more than twofold. And the proportion of infants with moderate-severe BPD who were exclusively fed human milk at discharge increased at the same rate. Conclusions: Our work shows an inverse relationship between human milk feeding at discharge from the neonatal unit and the occurrence of BPD. |
format | Online Article Text |
id | pubmed-10378323 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-103783232023-07-29 Human Milk Feeding Is Associated with Decreased Incidence of Moderate-Severe Bronchopulmonary Dysplasia in Extremely Preterm Infants Verd, Sergio Porta, Roser Ginovart, Gemma Avila-Alvarez, Alejandro García-Muñoz Rodrigo, Fermín Izquierdo Renau, Montserrat Ventura, Paula Sol Children (Basel) Article Background: An increased rate of bronchopulmonary dysplasia (BPD) is reported in extremely preterm infants. A potential role of human milk feeding in protecting against this condition has been suggested. Methods: A retrospective descriptive study was conducted based on data about morbidity in the population of infants born between 22+0 and 26+6 weeks of gestation, included in the Spanish network SEN1500 during the period 2004–2019 and discharged alive. The primary outcome was moderate-severe BPD. Associated conditions were studied, including human milk feeding at discharge. The temporal trends of BPD and human milk feeding rates at discharge were also studied. Results: In the study population of 4341 infants, the rate of moderate-severe BPD was 43.7% and it increased to >50% in the last three years. The factors significantly associated with a higher risk of moderate-severe BPD were birth weight, male sex, high-frequency oscillatory ventilation, duration of invasive mechanical ventilation, inhaled nitric oxide, patent ductus arteriosus, and late-onset sepsis. Exclusive human milk feeding and any amount of human milk at discharge were associated with a lower incidence of moderate-severe BPD (OR 0.752, 95% CI 0.629–0.901 and OR 0.714, 95% CI 0.602–0.847, respectively). During the study period, the proportion of infants with moderate-severe BPD fed any amount of human milk at discharge increased more than twofold. And the proportion of infants with moderate-severe BPD who were exclusively fed human milk at discharge increased at the same rate. Conclusions: Our work shows an inverse relationship between human milk feeding at discharge from the neonatal unit and the occurrence of BPD. MDPI 2023-07-23 /pmc/articles/PMC10378323/ /pubmed/37508764 http://dx.doi.org/10.3390/children10071267 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Verd, Sergio Porta, Roser Ginovart, Gemma Avila-Alvarez, Alejandro García-Muñoz Rodrigo, Fermín Izquierdo Renau, Montserrat Ventura, Paula Sol Human Milk Feeding Is Associated with Decreased Incidence of Moderate-Severe Bronchopulmonary Dysplasia in Extremely Preterm Infants |
title | Human Milk Feeding Is Associated with Decreased Incidence of Moderate-Severe Bronchopulmonary Dysplasia in Extremely Preterm Infants |
title_full | Human Milk Feeding Is Associated with Decreased Incidence of Moderate-Severe Bronchopulmonary Dysplasia in Extremely Preterm Infants |
title_fullStr | Human Milk Feeding Is Associated with Decreased Incidence of Moderate-Severe Bronchopulmonary Dysplasia in Extremely Preterm Infants |
title_full_unstemmed | Human Milk Feeding Is Associated with Decreased Incidence of Moderate-Severe Bronchopulmonary Dysplasia in Extremely Preterm Infants |
title_short | Human Milk Feeding Is Associated with Decreased Incidence of Moderate-Severe Bronchopulmonary Dysplasia in Extremely Preterm Infants |
title_sort | human milk feeding is associated with decreased incidence of moderate-severe bronchopulmonary dysplasia in extremely preterm infants |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10378323/ https://www.ncbi.nlm.nih.gov/pubmed/37508764 http://dx.doi.org/10.3390/children10071267 |
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