The 2EF Antibody Targets a Unique N-Terminal Epitope of Trop-2 and Enhances the In Vivo Activity of the Cancer-Selective 2G10 Antibody

SIMPLE SUMMARY: We sought recognition of Trop-2 within difficult-to-reach, densely packed tumor sites. The 2EF mAb was developed, and demonstrated efficient access to Trop-2 at cell–cell junctions in breast cancer cells in culture and in prostate tumors that were not accessible to benchmark anti-Tro...

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Detalles Bibliográficos
Autores principales: Guerra, Emanuela, Trerotola, Marco, Relli, Valeria, Lattanzio, Rossano, Ceci, Martina, Boujnah, Khouloud, Pantalone, Ludovica, Di Pietro, Roberta, Iezzi, Manuela, Tinari, Nicola, Alberti, Saverio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10378344/
https://www.ncbi.nlm.nih.gov/pubmed/37509383
http://dx.doi.org/10.3390/cancers15143721

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