Heroin Self-Administration and Extinction Increase Prelimbic Cortical Astrocyte–Synapse Proximity and Alter Dendritic Spine Morphometrics That Are Reversed by N-Acetylcysteine

Clinical and preclinical studies indicate that adaptations in corticostriatal neurotransmission significantly contribute to heroin relapse vulnerability. In animal models, heroin self-administration and extinction produce cellular adaptations in both neurons and astrocytes within the nucleus accumbe...

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Detalles Bibliográficos
Autores principales: Siemsen, Benjamin M., Denton, Adam R., Parrila-Carrero, Jeffrey, Hooker, Kaylee N., Carpenter, Eilish A., Prescot, Meagan E., Brock, Ashley G., Westphal, Annaka M., Leath, Mary-Nan, McFaddin, John A., Jhou, Thomas C., McGinty, Jacqueline F., Scofield, Michael D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10378353/
https://www.ncbi.nlm.nih.gov/pubmed/37508477
http://dx.doi.org/10.3390/cells12141812

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