Targeting RAF Isoforms and Tumor Microenvironments in RAS or BRAF Mutant Colorectal Cancers with SJ-C1044 for Anti-Tumor Activity

Colorectal cancer (CRC) is a significant global health issue characterized by a high prevalence of KRAS gene mutations. The RAS/MAPK pathway, involving KRAS, plays a crucial role in CRC progression. Although some RAS inhibitors have been approved, their efficacy in CRC is limited. To overcome these...

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Detalles Bibliográficos
Autores principales: Hong, Sungpyo, Jeon, Myeongjin, Kwon, Jeonghee, Park, Hanbyeol, Lee, Goeun, Kim, Kilwon, Ahn, Soonkil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10378394/
https://www.ncbi.nlm.nih.gov/pubmed/37504287
http://dx.doi.org/10.3390/cimb45070371

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10378394/
https://www.ncbi.nlm.nih.gov/pubmed/37504287
http://dx.doi.org/10.3390/cimb45070371

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