A Prochlorperazine-Induced Decrease in Autonomous Muscle Activity during Hindlimb Unloading Is Accompanied by Preserved Slow Myosin mRNA Expression

Skeletal muscle disuse leads to pathological muscle activity as well as to slow-to-fast fiber-type transformation. Fast-type fibers are more fatigable than slow-type, so this transformation leads to a decline in muscle function. Prochlorperazine injections previously were shown to attenuate autonomo...

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Autores principales: Sharlo, Kristina A., Lvova, Irina D., Tyganov, Sergey A., Sergeeva, Ksenia V., Kalashnikov, Vitaly Y., Kalashnikova, Ekaterina P., Mirzoev, Timur M., Kalamkarov, Grigoriy R., Shevchenko, Tatiana F., Shenkman, Boris S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10378404/
https://www.ncbi.nlm.nih.gov/pubmed/37504270
http://dx.doi.org/10.3390/cimb45070354
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author Sharlo, Kristina A.
Lvova, Irina D.
Tyganov, Sergey A.
Sergeeva, Ksenia V.
Kalashnikov, Vitaly Y.
Kalashnikova, Ekaterina P.
Mirzoev, Timur M.
Kalamkarov, Grigoriy R.
Shevchenko, Tatiana F.
Shenkman, Boris S.
author_facet Sharlo, Kristina A.
Lvova, Irina D.
Tyganov, Sergey A.
Sergeeva, Ksenia V.
Kalashnikov, Vitaly Y.
Kalashnikova, Ekaterina P.
Mirzoev, Timur M.
Kalamkarov, Grigoriy R.
Shevchenko, Tatiana F.
Shenkman, Boris S.
author_sort Sharlo, Kristina A.
collection PubMed
description Skeletal muscle disuse leads to pathological muscle activity as well as to slow-to-fast fiber-type transformation. Fast-type fibers are more fatigable than slow-type, so this transformation leads to a decline in muscle function. Prochlorperazine injections previously were shown to attenuate autonomous rat soleus muscle electrical activity under unloading conditions. In this study, we found that prochlorperazine blocks slow-to-fast fiber-type transformation in disused skeletal muscles of rats, possibly through affecting calcium and ROS-related signaling.
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spelling pubmed-103784042023-07-29 A Prochlorperazine-Induced Decrease in Autonomous Muscle Activity during Hindlimb Unloading Is Accompanied by Preserved Slow Myosin mRNA Expression Sharlo, Kristina A. Lvova, Irina D. Tyganov, Sergey A. Sergeeva, Ksenia V. Kalashnikov, Vitaly Y. Kalashnikova, Ekaterina P. Mirzoev, Timur M. Kalamkarov, Grigoriy R. Shevchenko, Tatiana F. Shenkman, Boris S. Curr Issues Mol Biol Article Skeletal muscle disuse leads to pathological muscle activity as well as to slow-to-fast fiber-type transformation. Fast-type fibers are more fatigable than slow-type, so this transformation leads to a decline in muscle function. Prochlorperazine injections previously were shown to attenuate autonomous rat soleus muscle electrical activity under unloading conditions. In this study, we found that prochlorperazine blocks slow-to-fast fiber-type transformation in disused skeletal muscles of rats, possibly through affecting calcium and ROS-related signaling. MDPI 2023-06-30 /pmc/articles/PMC10378404/ /pubmed/37504270 http://dx.doi.org/10.3390/cimb45070354 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Sharlo, Kristina A.
Lvova, Irina D.
Tyganov, Sergey A.
Sergeeva, Ksenia V.
Kalashnikov, Vitaly Y.
Kalashnikova, Ekaterina P.
Mirzoev, Timur M.
Kalamkarov, Grigoriy R.
Shevchenko, Tatiana F.
Shenkman, Boris S.
A Prochlorperazine-Induced Decrease in Autonomous Muscle Activity during Hindlimb Unloading Is Accompanied by Preserved Slow Myosin mRNA Expression
title A Prochlorperazine-Induced Decrease in Autonomous Muscle Activity during Hindlimb Unloading Is Accompanied by Preserved Slow Myosin mRNA Expression
title_full A Prochlorperazine-Induced Decrease in Autonomous Muscle Activity during Hindlimb Unloading Is Accompanied by Preserved Slow Myosin mRNA Expression
title_fullStr A Prochlorperazine-Induced Decrease in Autonomous Muscle Activity during Hindlimb Unloading Is Accompanied by Preserved Slow Myosin mRNA Expression
title_full_unstemmed A Prochlorperazine-Induced Decrease in Autonomous Muscle Activity during Hindlimb Unloading Is Accompanied by Preserved Slow Myosin mRNA Expression
title_short A Prochlorperazine-Induced Decrease in Autonomous Muscle Activity during Hindlimb Unloading Is Accompanied by Preserved Slow Myosin mRNA Expression
title_sort prochlorperazine-induced decrease in autonomous muscle activity during hindlimb unloading is accompanied by preserved slow myosin mrna expression
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10378404/
https://www.ncbi.nlm.nih.gov/pubmed/37504270
http://dx.doi.org/10.3390/cimb45070354
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