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Paediatric Spitzoid Neoplasms: 10-Year Retrospective Study Characterizing Histological, Clinical, Dermoscopic Presentation and FISH Test Results

Introduction: Spitzoid lesions are a wide tumour class comprising Spitz nevus (SN), atypical Spitz tumour (AST) and Spitz melanoma (SM). Materials and Methods: We conducted a single-centre-based retrospective survey on all histologically diagnosed spitzoid lesions of paediatric patients (1–18 years)...

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Autores principales: Herzum, Astrid, Occella, Corrado, Vellone, Valerio Gaetano, Gariazzo, Lodovica, Pastorino, Carlotta, Ferro, Jacopo, Sementa, Angela, Mazzocco, Katia, Vercellino, Nadia, Viglizzo, Gianmaria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10378405/
https://www.ncbi.nlm.nih.gov/pubmed/37510125
http://dx.doi.org/10.3390/diagnostics13142380
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author Herzum, Astrid
Occella, Corrado
Vellone, Valerio Gaetano
Gariazzo, Lodovica
Pastorino, Carlotta
Ferro, Jacopo
Sementa, Angela
Mazzocco, Katia
Vercellino, Nadia
Viglizzo, Gianmaria
author_facet Herzum, Astrid
Occella, Corrado
Vellone, Valerio Gaetano
Gariazzo, Lodovica
Pastorino, Carlotta
Ferro, Jacopo
Sementa, Angela
Mazzocco, Katia
Vercellino, Nadia
Viglizzo, Gianmaria
author_sort Herzum, Astrid
collection PubMed
description Introduction: Spitzoid lesions are a wide tumour class comprising Spitz nevus (SN), atypical Spitz tumour (AST) and Spitz melanoma (SM). Materials and Methods: We conducted a single-centre-based retrospective survey on all histologically diagnosed spitzoid lesions of paediatric patients (1–18 years) of the last 10 years (2012–2022). Histopathological reports and electronic records of patients were used to retrieve relevant data regarding patients’ features, clinical and dermatoscopical aspects of lesions when recorded, and FISH tests when present. Results: Of 255 lesions, 82% were histologically benign, 17% atypical, 1% malignant. Clinically, 100% of SM were large (≥6 mm) and raised; AST were mainly large (63%), raised (98%), pink (95%). Small (≤5 mm), pigmented, flat lesions correlated with benign histology (respectively 90%, 97%, 98% SN) (p < 0.0001). Dermatoscopical patterns were analysed in 100 patients: starburst pattern correlated with benign histology (26% SN (p = 0.004)), while multicomponent pattern correlated with atypical/malignant lesions (56% AST, 50% SM (p = 0.0052)). Eighty-five lesions were subjected to fluorescence in situ hybridization (FISH): 34 (71% AST; 29% SN) were FISH-positive; 51 (63% SN; 37% AST) were FISH-negative (p = 0.0038). Discussion: This study confirmed predominant benign histology (82%) of paediatric spitzoid lesions, thus detecting 17% AST and 1% SM, highlighting the need for caution in handling spitzoid lesions. Conclusion: Until AST are considered potentially malignant proliferations and no reliable criteria are identified to distinguish them, the authors suggest a prudent approach, especially in children.
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spelling pubmed-103784052023-07-29 Paediatric Spitzoid Neoplasms: 10-Year Retrospective Study Characterizing Histological, Clinical, Dermoscopic Presentation and FISH Test Results Herzum, Astrid Occella, Corrado Vellone, Valerio Gaetano Gariazzo, Lodovica Pastorino, Carlotta Ferro, Jacopo Sementa, Angela Mazzocco, Katia Vercellino, Nadia Viglizzo, Gianmaria Diagnostics (Basel) Article Introduction: Spitzoid lesions are a wide tumour class comprising Spitz nevus (SN), atypical Spitz tumour (AST) and Spitz melanoma (SM). Materials and Methods: We conducted a single-centre-based retrospective survey on all histologically diagnosed spitzoid lesions of paediatric patients (1–18 years) of the last 10 years (2012–2022). Histopathological reports and electronic records of patients were used to retrieve relevant data regarding patients’ features, clinical and dermatoscopical aspects of lesions when recorded, and FISH tests when present. Results: Of 255 lesions, 82% were histologically benign, 17% atypical, 1% malignant. Clinically, 100% of SM were large (≥6 mm) and raised; AST were mainly large (63%), raised (98%), pink (95%). Small (≤5 mm), pigmented, flat lesions correlated with benign histology (respectively 90%, 97%, 98% SN) (p < 0.0001). Dermatoscopical patterns were analysed in 100 patients: starburst pattern correlated with benign histology (26% SN (p = 0.004)), while multicomponent pattern correlated with atypical/malignant lesions (56% AST, 50% SM (p = 0.0052)). Eighty-five lesions were subjected to fluorescence in situ hybridization (FISH): 34 (71% AST; 29% SN) were FISH-positive; 51 (63% SN; 37% AST) were FISH-negative (p = 0.0038). Discussion: This study confirmed predominant benign histology (82%) of paediatric spitzoid lesions, thus detecting 17% AST and 1% SM, highlighting the need for caution in handling spitzoid lesions. Conclusion: Until AST are considered potentially malignant proliferations and no reliable criteria are identified to distinguish them, the authors suggest a prudent approach, especially in children. MDPI 2023-07-15 /pmc/articles/PMC10378405/ /pubmed/37510125 http://dx.doi.org/10.3390/diagnostics13142380 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Herzum, Astrid
Occella, Corrado
Vellone, Valerio Gaetano
Gariazzo, Lodovica
Pastorino, Carlotta
Ferro, Jacopo
Sementa, Angela
Mazzocco, Katia
Vercellino, Nadia
Viglizzo, Gianmaria
Paediatric Spitzoid Neoplasms: 10-Year Retrospective Study Characterizing Histological, Clinical, Dermoscopic Presentation and FISH Test Results
title Paediatric Spitzoid Neoplasms: 10-Year Retrospective Study Characterizing Histological, Clinical, Dermoscopic Presentation and FISH Test Results
title_full Paediatric Spitzoid Neoplasms: 10-Year Retrospective Study Characterizing Histological, Clinical, Dermoscopic Presentation and FISH Test Results
title_fullStr Paediatric Spitzoid Neoplasms: 10-Year Retrospective Study Characterizing Histological, Clinical, Dermoscopic Presentation and FISH Test Results
title_full_unstemmed Paediatric Spitzoid Neoplasms: 10-Year Retrospective Study Characterizing Histological, Clinical, Dermoscopic Presentation and FISH Test Results
title_short Paediatric Spitzoid Neoplasms: 10-Year Retrospective Study Characterizing Histological, Clinical, Dermoscopic Presentation and FISH Test Results
title_sort paediatric spitzoid neoplasms: 10-year retrospective study characterizing histological, clinical, dermoscopic presentation and fish test results
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10378405/
https://www.ncbi.nlm.nih.gov/pubmed/37510125
http://dx.doi.org/10.3390/diagnostics13142380
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