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RNA Helicase Vasa as a Multifunctional Conservative Regulator of Gametogenesis in Eukaryotes
Being a conservative marker of germ cells across metazoan species, DEAD box RNA helicase Vasa (DDX4) remains the subject of worldwide investigations thanks to its multiple functional manifestations. Vasa takes part in the preformation of primordial germ cells in a group of organisms and contributes...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10378496/ https://www.ncbi.nlm.nih.gov/pubmed/37504274 http://dx.doi.org/10.3390/cimb45070358 |
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author | Adashev, Vladimir E. Kotov, Alexei A. Olenina, Ludmila V. |
author_facet | Adashev, Vladimir E. Kotov, Alexei A. Olenina, Ludmila V. |
author_sort | Adashev, Vladimir E. |
collection | PubMed |
description | Being a conservative marker of germ cells across metazoan species, DEAD box RNA helicase Vasa (DDX4) remains the subject of worldwide investigations thanks to its multiple functional manifestations. Vasa takes part in the preformation of primordial germ cells in a group of organisms and contributes to the maintenance of germline stem cells. Vasa is an essential player in the piRNA-mediated silencing of harmful genomic elements and in the translational regulation of selected mRNAs. Vasa is the top hierarchical protein of germ granules, liquid droplet organelles that compartmentalize RNA processing factors. Here, we survey current advances and problems in the understanding of the multifaceted functions of Vasa proteins in the gametogenesis of different eukaryotic organisms, from nematodes to humans. |
format | Online Article Text |
id | pubmed-10378496 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-103784962023-07-29 RNA Helicase Vasa as a Multifunctional Conservative Regulator of Gametogenesis in Eukaryotes Adashev, Vladimir E. Kotov, Alexei A. Olenina, Ludmila V. Curr Issues Mol Biol Review Being a conservative marker of germ cells across metazoan species, DEAD box RNA helicase Vasa (DDX4) remains the subject of worldwide investigations thanks to its multiple functional manifestations. Vasa takes part in the preformation of primordial germ cells in a group of organisms and contributes to the maintenance of germline stem cells. Vasa is an essential player in the piRNA-mediated silencing of harmful genomic elements and in the translational regulation of selected mRNAs. Vasa is the top hierarchical protein of germ granules, liquid droplet organelles that compartmentalize RNA processing factors. Here, we survey current advances and problems in the understanding of the multifaceted functions of Vasa proteins in the gametogenesis of different eukaryotic organisms, from nematodes to humans. MDPI 2023-07-05 /pmc/articles/PMC10378496/ /pubmed/37504274 http://dx.doi.org/10.3390/cimb45070358 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Adashev, Vladimir E. Kotov, Alexei A. Olenina, Ludmila V. RNA Helicase Vasa as a Multifunctional Conservative Regulator of Gametogenesis in Eukaryotes |
title | RNA Helicase Vasa as a Multifunctional Conservative Regulator of Gametogenesis in Eukaryotes |
title_full | RNA Helicase Vasa as a Multifunctional Conservative Regulator of Gametogenesis in Eukaryotes |
title_fullStr | RNA Helicase Vasa as a Multifunctional Conservative Regulator of Gametogenesis in Eukaryotes |
title_full_unstemmed | RNA Helicase Vasa as a Multifunctional Conservative Regulator of Gametogenesis in Eukaryotes |
title_short | RNA Helicase Vasa as a Multifunctional Conservative Regulator of Gametogenesis in Eukaryotes |
title_sort | rna helicase vasa as a multifunctional conservative regulator of gametogenesis in eukaryotes |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10378496/ https://www.ncbi.nlm.nih.gov/pubmed/37504274 http://dx.doi.org/10.3390/cimb45070358 |
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